The National Quantum Technologies Programme, which began in 2013, has now entered its second phase of funding, part of which will be a £94 million investment by the UK government, via UK Research and Innovation’s (UKRI) Engineering and Physical Sciences Research Council (EPSRC), in four Quantum Technologies Research Hubs.

The University of Cambridge is a partner in the Quantum Communications Hub, led by the University of York, which is pursuing quantum communications at all distance scales, to offer a range of applications and services and the potential for integration with existing infrastructure.

Through these Hubs, the UK’s world-leading quantum technologies research base will continue to drive the development of new technologies through their networks of academic and business partnerships.

“Harnessing the full potential of emerging technologies is vital as we strive to meet our Industrial Strategy ambition to be the most innovative economy in the world,” said Science Minister Chris Skidmore. “Our world-leading universities are pioneering ways to apply quantum technologies that could have serious commercial benefits for UK businesses. That’s why I am delighted to be announcing further investment in Quantum Technology Hubs that will bring academics and innovators together and make this once-futuristic technology applicable to our everyday lives.”

“The UK is leading the field in developing Quantum Technologies and this new investment will help us make the next leap forward in the drive to link discoveries to innovative applications. UKRI is committed to ensuring the best research and researchers are supported in this area,” said Professor Sir Mark Walport, Chief Executive of UKRI.

The Quantum Communications Hub has already established the UK’s first quantum network, the UKQN. They will be extending and enhancing the UKQN, adding function and capability, and introducing new Quantum Key Distribution (QKD) technologies – using quantum light analogous to that used in conventional communications, or using entanglement working towards even longer distance fibre communications.

“We will be extending the UKQN to a national scale, with links over the EPSRC National Dark Fibre Facility to London and Bristol, as well as a link to our industrial partner BT in Adastral Park in Ipswich,” said Professor Richard Penty from the Department of Engineering. “We will be using this network to trial more advanced quantum communications technologies, including quantum repeaters, quantum entanglement, continuous variable QKD and new algorithms.”

Although widely applicable, key-sharing does not provide a solution for all secure communication scenarios. The Hub will research other new quantum protocols and the incorporation of QKD into wider security solutions. Professor Adrian Kent from the Department of Applied Mathematics and Theoretical Physics is co-leading this work with other theorists in the Hub.

“We have been devising new applications of quantum communication which allow new secure cryptographic schemes, often also making use of the impossibility of faster-than-light signalling,” said Kent. “We have also been working with experimentalist colleagues in the Hub on the practical implementation of some of these schemes, for example over the UK Quantum Network.

“The next phase of the Hub will allow us to extend our theoretical work and experimental collaborations, including work on space-based implementations via satellite links.”

The Cambridge researchers will also be working on quantum communications on a chip, particularly for the networking aspects. “One of the barriers for take-up of quantum communications is that the transmitters and receivers are bespoke and made from discrete components,” said Penty. “Integrating many of the functions on the same chip will reduce the costs and speed up commercialisation.”

Given the changing landscape worldwide, it is becoming increasingly important for the UK to establish national capability, both in quantum communication technologies and their key components such as light sources and detectors. The Hub has assembled an excellent team to deliver this capability.

Adapted from a UKRI press release.

Recent innovations in engineered timber have laid the foundations for the world’s first wooden skyscrapers to appear within a decade, a feat that is not only achievable—according to the Centre for Natural Material Innovation—but one they hope will beckon in an era of sustainable wooden cities, helping reverse historic emissions from the construction industry.

The research team based at the Faculty of Architecture, is interdisciplinary, composed of architects, biochemists, chemists, mathematicians and engineers, who specialise in plant-based material, including cross-laminated timber, arguably the first major structural innovation since the advent of reinforced concrete, 150 years ago.

Principal Investigator Dr Michael Ramage, said “Until cross-laminated timber, there was simply no building material to challenge steel or reinforced concrete. To construct cities and indeed skyscrapers, we just had to accept the good and the bad of existing materials.

“Concrete is about five times heavier than timber, which means more expense for foundations and transport; it’s resource-intensive, and contributes to tremendous carbon dioxide emissions. After water, concrete is the most consumed material by humanity. But now we have an alternative, and it’s plant-based.”

The team envisage trees supplanting concrete as the predominant building material for cities, with buildings sown like seeds and cities harvested as crops, a way of simultaneously addressing climate change and global housing shortages.

Dr Ramage explained: “In England alone, we need to build 340,000 new homes each year over the next 12 years to accommodate our population. Concrete is unsustainable. Timber, however, is the only building material we can grow, and that actually reduces carbon dioxide. Every tonne of timber expunges 1.8 tonnes of carbon dioxide from the atmosphere. Doing the calculations, if all new English homes were constructed from timber, we could capture and offset the carbon footprints of around 850,000 people for 10 years.

“The sustainable forests of Europe take just 7 seconds to grow the volume of timber required for a 3 bedroom apartment, and 4 hours to grow a 300 metre supertall skyscraper. Canada’s sustainable forests alone yield enough timber to house a billion people in perpetuity, with forested trees replenishing faster than their eventual occupants.”

Various teams around the world are hoping to produce the tallest wooden skyscraper, however the team from Cambridge is confident they’ll be the first, having done holistic work on three proposals for timber skyscrapers in London, Chicago, and the Hague, all of which are set to be showcased to the public at the Royal Society’s Summer Science Exhibition 2019, freely open to the public from July 1–7.

The team’s exhibit—Timber towers of tomorrow—will embody their vision, the stand itself modelled after a typical apartment nested within their proposed Oakwood Timber Tower at the Barbican Tower, where visitors can experience life in a treehouse while talking with the team, viewing architectural models of timber towers, learning about the fire performance properties of engineered timber, and hearing about the genetic, cellular, and macroscale innovations which have led to ply in the sky designs becoming a reality.

Beyond tackling climate change and promoting sustainability, the team are eager to outline the branching benefits society stands to gain by embracing timber architecture: the psychological well-being that comes from being surrounded by wood as compared with concrete, as well as the return to an ancient building material, that’s intimate as it is natural.

We’ve all done it, offered an excuse for our poor behaviour or rude reactions to others in the heat of the moment, after a long commute or a tough day with the kids. Excuses are commonplace, an attempt to explain and justify behaviours we aren’t proud of, to escape the consequences of our acts and make our undesirable behaviour more socially acceptable.

The things we appeal to when making excuses are myriad: tiredness, stress, a looming work deadline, a wailing infant, poverty, a migraine, ignorance. But what do these various excuses have in common that allows us to recognize them all as plausible? Do they differ from the excuses used in criminal law, like duress or coercion? And what does having an excuse get us – does it really exonerate us?

A researcher from Cambridge University has suggested that the answers lie in what they all tell us about our underlying motivation. When excuses are permissible, it’s because they show that while we acted wrongly, our underlying moral intentions were adequate.

Intentions are plans for action. To say that your intention was morally adequate is to say that your plan for action was morally sound. So when you make an excuse, you plead that your plan for action was morally fine – it’s just that something went awry in putting it into practice. Perhaps you tripped, and that’s why you spilled the shopping you were helping to carry. Or you were stressed or exhausted, which meant you couldn’t execute your well-intentioned plan.

This research presents for the first time a unified account of excuses – the Good Intention Account – that argues our everyday excuses work in much the same way as those offered in a courtroom. When lawyers appeal to duress or provocation in defense of their client, they are claiming that the client may have broken the law but had a morally adequate intention: she was just prevented from acting on it because fear or anger led her to lose self-control.

Until now little light has been shed on what unifies the diverse bunch of everyday reasons we offer when making excuses. Dr Paulina Sliwa’s study from the Faculty of Philosophy, suggests a morally adequate intention is the crucial ingredient.

Recent work in psychology suggests that intentions have a distinctive motivational profile, with philosophers and psychologists both arguing that they are key to understanding how we make choices. Dr Sliwa argues that intentions are the key to making sense of our everyday morality.

Dr Sliwa goes on to explain that appealing to excuses has its limits. “Successful excuses can mitigate our blame but they don’t get us off the hook completely. Saying we were tired or stressed doesn’t absolve us from moral responsibility completely, though they do change others’ perceptions of what we owe to make up for it and how the offended party should feel about our wrongdoing.”

This means that when we make excuses we are trying to haggle, to negotiate whether we deserve anger and resentment, or punishment and how much we need to apologise or compensate. This is why it can be so annoying if someone makes spurious excuses – and also probably why we continue to make excuses in the first place.

Dr Sliwa said, “A successful excuse needs to make plausible that your intention really was morally adequate – but something beyond your control prevented you from translating it into action. That’s why considerations like the following often work: I am sorry for forgetting the appointment – I had a terrible migraine / I haven’t slept for the last three nights / I was preoccupied with worries about my mother’s health; or I’m sorry I broke your vase – I stumbled over the rug. They all indicate an adequate underlying moral motivation that was thwarted by external circumstances.

“Things that will never work are appeals to weakness of will ‘I just couldn’t resist’ or ‘it was too tempting’ don’t work. Nor do appeals to things that are obviously immoral.

“The same is true of legal excuses: not every appeal to duress, coercion or provocation will be successful – it will depend on the details of the case.

“Philosophy can give us a better understanding of our mundane, everyday moral phenomena. There are a lot more puzzles to think about in relation with excuses: what’s the difference between explaining someone’s bad behavior and excusing it?”

The study is published in the ethics journal Philosophy and Public Affairs.

A free version is available at: http://paulinasliwa.weebly.com/uploads/1/9/0/4/19046427/final_submission.pdf

As technology improves, so too does our ability to create life-like artificial agents, such as robots and computer graphics – but this can be a double-edged sword.

“Resembling the human shape or behaviour can be both an advantage and a drawback,” explains Professor Astrid Rosenthal-von der Pütten, Chair for Individual and Technology at RWTH Aachen University. “The likeability of an artificial agent increases the more human-like it becomes, but only up to a point: sometimes people seem not to like it when the robot or computer graphic becomes too human-like.”

This phenomenon was first described in 1978 by robotics professor Masahiro Mori, who coined an expression in Japanese that went on to be translated as the ‘Uncanny Valley’.

Now, in a series of experiments reported in the Journal of Neuroscience, neuroscientists and psychologists in the UK and Germany have identified mechanisms within the brain that they say help explain how this phenomenon occurs – and may even suggest ways to help developers improve how people respond.

“For a neuroscientist, the ‘Uncanny Valley’ is an interesting phenomenon,” explains Dr Fabian Grabenhorst, a Sir Henry Dale Fellow and Lecturer in the Department of Physiology, Development and Neuroscience at the University of Cambridge. “It implies a neural mechanism that first judges how close a given sensory input, such as the image of a robot, lies to the boundary of what we perceive as a human or non-human agent. This information would then be used by a separate valuation system to determine the agent’s likeability.”

To investigate these mechanisms, the researchers studied brain patterns in 21 healthy individuals during two different tests using functional magnetic resonance imaging (fMRI), which measures changes in blood flow within the brain as a proxy for how active different regions are.

In the first test, participants were shown a number of images that included humans, artificial humans, android robots, humanoid robots and mechanoid robots, and were asked to rate them in terms of likeability and human-likeness.

Then, in a second test, the participants were asked to decide which of these agents they would trust to select a personal gift for them, a gift that a human would like. Here, the researchers found that participants generally preferred gifts from humans or from the more human-like artificial agents – except those that were closest to the human/non-human boundary, in-keeping with the Uncanny Valley phenomenon.

By measuring brain activity during these tasks, the researchers were able to identify which brain regions were involved in creating the sense of the Uncanny Valley. They traced this back to brain circuits that are important in processing and evaluating social cues, such as facial expressions.

Some of the brain areas close to the visual cortex, which deciphers visual images, tracked how human-like the images were, by changing their activity the more human-like an artificial agent became – in a sense, creating a spectrum of ‘human-likeness’.

Along the midline of the frontal lobe, where the left and right brain hemispheres meet, there is a wall of neural tissue known as the medial prefrontal cortex. In previous studies, the researchers have shown that this brain region contains a generic valuation system that judges all kinds of stimuli; for example, they showed previously that this brain area signals the reward value of pleasant high-fat milkshakes and also of social stimuli such as pleasant touch.

In the present study, two distinct parts of the medial prefrontal cortex were important for the Uncanny Valley. One part converted the human-likeness signal into a ‘human detection’ signal, with activity in this region over-emphasising the boundary between human and non-human stimuli – reacting most strongly to human agents and much less to artificial agents.

The second part, the ventromedial prefrontal cortex (VMPFC), integrated this signal with a likeability evaluation to produce a distinct activity pattern that closely matched the Uncanny Valley response.

“We were surprised to see that the ventromedial prefrontal cortex responded to artificial agents precisely in the manner predicted by the Uncanny Valley hypothesis, with stronger responses to more human-like agents but then showing a dip in activity close to the human/non-human boundary—the characteristic ‘valley’,” says Dr Grabenhorst.

The same brain areas were active when participants made decisions about whether to accept a gift from a robot by signalling the evaluations that guided participants’ choices. One further region – the amygdala, which is responsible for emotional responses – was particularly active when participants rejected gifts from the human-like, but not human, artificial agents. The amygdala’s ‘rejection signal’ was strongest in participants who were more likely to refuse gifts from artificial agents.

The results could have implications for the design of more likable artificial agents. Dr Grabenhorst explains: “We know that valuation signals in these brain regions can be changed through social experience. So, if you experience that an artificial agent makes the right choices for you – such as choosing the best gift – then your ventromedial prefrontal cortex might respond more favourably to this new social partner.”

“This is the first study to show individual differences in the strength of the Uncanny Valley effect, meaning that some individuals react overly and others less sensitively to human-like artificial agents,” says Professor Rosenthal-von der Pütten. “This means there is no one robot design that fits—or scares—all users. In my view, smart robot behaviour is of great importance, because users will abandon robots that do not prove to be smart and useful.”

The research was funded by Wellcome and the German Academic Scholarship Foundation.

Reference
Rosenthal-von der Pütten, AM et al. Neural Mechanisms for Accepting and Rejecting Artificial Social Partners in the Uncanny Valley. Journal of Neuroscience; 1 July 2019; DOI: 10.1523/JNEUROSCI.2956-18.2019

I am fascinated by the physics of the Universe across the largest scales. I am a theoretical physicist by training and specialise in theoretical and mathematical physics. I was awarded a PhD in Theoretical Cosmology from LMU Munich. I spent two years as a Research Associate at Utrecht University before moving to Cambridge, and am now a Research Associate at the Stephen Hawking Centre for Theoretical Cosmology and a Junior Research Fellow at Fitzwilliam College.

I am embedded in an active and diverse community – from applied mathematics to astrophysics and astronomy. Since I am applying methods from different fields of physics and mathematics to problems in cosmology, it’s invaluable to be among experts in all kind of areas. I also find it quite stimulating to be surrounded by so many smart and motivated young researchers.

My research aims at understanding the cosmic web – the skeleton of matter in our Universe. With large telescopes, we can see this cosmic web as an intricate pattern of galaxies on the sky. I’m trying to describe how those structures were formed. This is particularly interesting because we know that there were virtually no structures in the early universe. If we look at the afterglow of the Big Bang, the so-called cosmic microwave background, we observe that the matter was evenly distributed across the universe with tiny deviations of 10 parts in a million.

My research can feel a bit like detective work. We are trying to unveil what drives the evolution of our universe and determines its fate from a couple of key observations.  I find it fascinating to look for models that can describe almost 13 billion years of cosmic history. Since I am a theorist, I spend a large part of my day thinking, reading and calculating. Thanks to the active scientific life at DAMTP, almost all of my days include listening to seminars or colloquia talks and chatting to my colleagues from a lot of different fields of theoretical physics. When I am not travelling, I usually work either in the Centre for Mathematical Sciences or in Fitzwilliam College.

My favourite project is describing galaxy clustering using number counts. What I find so fascinating is that there are certain clustering statistics that contain a lot of information and can still be predicted accurately. This situation is quite remarkable because in general, it is hard to make good predictions for gravitational clustering where initially small deviations from mean density are amplified (making the system highly nonlinear). As a theoretical physicist, I love to look for ’smart’ observables that can be calculated from first principles and provide an accurate description of observations in the real world.

In 2016 I spent an incredibly inspiring week with more than 30 Nobel Laureates. This was the Lindau Nobel Laureate Meeting in Physics, attended by more than 400 young participants. And as if that wasn’t thrilling enough, I also had the opportunity to present part of my PhD research in a plenary talk at the Bavarian evening. It was certainly a dare to give a scientific talk in a dirndl in front of so many people, but it sparked great discussions and I am happy I got this chance.

My advice to everyone is to follow your interests and strive to achieve your own goals. Find people who don’t push you around but push you forward. Seize the opportunities and don’t give up too easily. Explore, enjoy and try to make yourself comfortable outside your current comfort zone.

An online game in which people play the role of propaganda producers to help them identify real world disinformation has been shown to increase “psychological resistance” to fake news, according to a study of 15,000 participants.

In February 2018, University of Cambridge researchers helped launch the browser game Bad News. Thousands of people spent fifteen minutes completing it, with many allowing the data to be used for a study.

Players stoke anger and fear by manipulating news and social media within the simulation: deploying twitter bots, photo-shopping evidence, and inciting conspiracy theories to attract followers – all while maintaining a “credibility score” for persuasiveness.

“Research suggests that fake news spreads faster and deeper than the truth, so combatting disinformation after-the-fact can be like fighting a losing battle,” said Dr Sander van der Linden, Director of the Cambridge Social Decision-Making Lab.

“We wanted to see if we could pre-emptively debunk, or ‘pre-bunk’, fake news by exposing people to a weak dose of the methods used to create and spread disinformation, so they have a better understanding of how they might be deceived.

“This is a version of what psychologists call ‘inoculation theory’, with our game working like a psychological vaccination.”

To gauge the effects of the game, players were asked to rate the reliability of a series of different headlines and tweets before and after gameplay. They were randomly allocated a mixture of real (“control”) and fake news (“treatment”).

The study, published today in the journal Palgrave Communications, showed the perceived reliability of fake news before playing the game had reduced by an average of 21% after completing it. Yet the game made no difference to how users ranked real news.

The researchers also found that those who registered as most susceptible to fake news headlines at the outset benefited most from the “inoculation”.

“We find that just fifteen minutes of gameplay has a moderate effect, but a practically meaningful one when scaled across thousands of people worldwide, if we think in terms of building societal resistance to fake news,” said van der Linden.

Jon Roozenbeek, study co-author also from Cambridge University, said: “We are shifting the target from ideas to tactics. By doing this, we are hoping to create what you might call a general ‘vaccine’ against fake news, rather than trying to counter each specific conspiracy or falsehood.”

Roozenbeek and van der Linden worked with Dutch media collective DROG and design agency Gusmanson to develop Bad News, and the idea of a game to inoculate against fake news has attracted much attention.

Working with the UK Foreign Office, the team have translated the game into nine different languages, including German, Serbian, Polish and Greek. WhatsApp have commissioned the researchers to create a new game for the messaging platform.

The team have also created a “junior version” for children aged 8-10, available in ten different languages so far. “We want to develop a simple and engaging way to establish media literacy at a relatively early age, then look at how long the effects last,” said Roozenbeek.

This first set of results from Bad News has its limitations, say researchers. The sample was self-selecting (those who came across the game online and opted to play), and as such was skewed toward younger, male, liberal, and more educated demographics.

With this in mind, however, the study found the game to be almost equally effective across age, education, gender, and political persuasion. Bad News has ideological balance built in: players can choose to create fake news from the left and right of the political spectrum.

There are six “badges” to earn in the game, each reflecting a common strategy used by purveyors of fake news: impersonation; conspiracy; polarisation; discrediting sources; trolling; emotionally provocative content.

In-game questions measuring the effects of Bad News were deployed for four of its featured fake news badges.

For the disinformation tactic of “impersonation”, often seen in the mimicking of trusted personalities on social media, the game reduced perceived reliability of the fake headlines and tweets by 24% from pre to post gameplay.

Bad News gameplay reduced perceived reliability of deliberately polarising headlines by about 10%, and “discrediting” – attacking a legitimate source with accusations of bias – by 19%.

For “conspiracy”, the spreading of false narratives blaming secretive groups for world events, perceived reliability was reduced by 20%.

“Our platform offers early evidence of a way to start building blanket protection against deception, by training people to be more attuned to the techniques that underpin most fake news,” added Roozenbeek.

The MAterials Science Experiment Rocket (MASER) 14 was launched from the European Space Centre in Esrange, Sweden, in collaboration with the European Space Agency (ESA) and the Swedish Space Corporation (SSC).

The experiment aims to test the possibilities of printing graphene inks in space. Graphene inks can be used in the production of batteries, supercapacitors, printed electronics, and more. If researchers are able to demonstrate how these inks work in space, astronauts could potentially print their own devices on the go, or they can repair electronics with graphene ink printers.

The experiments conducted this week were a collaboration led by the University of Brussels, with Cambridge, Pisa, and ESA. The inks that were tested in the experiments were produced by the research group of Professor Andrea Ferrari, Director of the Cambridge Graphene Centre.

Studying the different self-assembly modes of graphene into functional patterns in zero gravity will enable the fabrication of graphene electronic devices during long-term space missions, as well as help understand fundamental properties of graphene printing on Earth.

Cambridge researchers pioneered the use of liquid phase exfoliation, one of the most common means of producing graphene, to prepare inks from graphene and related materials. Such inks are now used to print devices ranging from flexible electronic sensors and gauges to batteries and supercapacitors.

The experiments will allow researchers to better understand the fundamentals of the printing process on Earth, by removing the presence of gravity and studying how graphene flakes self-assemble.

These experiments are a first step towards making graphene printing available for long term space exploration, since astronauts may need to print electronic devices on demand during long-term missions. Graphene-based composites may also be used to offer radiation protection, a compulsory requirement for human spaceflight, for example during Mars-bound missions.

During its short flight, the MASER rocket experiences microgravity for six minutes, during which time the researchers carry out the tests of graphene’s properties. When the rocket returns to Earth, the samples are retrieved and analyses are carried out. The rocket tests are an extension of a zero-gravity parabolic flight in May 2018, where experiments were conducted during just 24 seconds of microgravity.

“There is no better way to validate graphene’s potential than to send it to the environment it will be used in,” said Carlo lorio, leader of the space activities carried out by the Graphene Flagship, and a researcher at Graphene Flagship partner Université Libre de Bruxelles. “Graphene has unique conductivity properties that scientists are continuing to take advantage of in new processes, devices and in this case, coatings. Experiments like these are fundamental to graphene’s success and integral for building the material’s reputation as the leading material for space applications.”

“The Graphene Flagship has pioneered the exploration of graphene for space applications since 2017,” said Ferrari, who is also Science and Technology Officer of the Graphene Flagship and Chair of its Management Panel. “With three microgravity campaigns in parabolic flights already concluded and a fourth one on the way, this rocket launch is the next step towards our major milestone: bringing graphene to the International Space Station. Space is the limit for graphene. Or, is it?”

Since the discovery of penicillin, the introduction of antibiotics to treat infections has revolutionised medicine and healthcare, saving millions of lives. However, widespread use (and misuse) of the drugs has led some bacteria to develop resistance, making the medicines less effective. With few new antibiotics in development, antibiotic resistance is widely considered a serious threat to the future of modern medicine, raising the spectre of untreatable infections.

One of the most widely used and clinically important groups of antibiotics is the family that includes penicillin and penicillin derivatives. The first type of penicillin resistance occurred when bacteria acquired an enzyme, known as a beta-lactamase, which destroys penicillin. To overcome this, drug manufacturers developed new derivatives of penicillin, such as methicillin, which were resistant to beta-lactamase.

In the escalating arms race, one particular type of bacteria known as Methicillin-resistant Staphylococcus aureus – MRSA – has developed widespread resistance to this class of drugs. MRSA has become a serious problem in hospital- and community-acquired infections, forcing doctors to turn to alternative antibiotics, or a cocktail of different drugs which are often less effective, and raises concerns that even these drugs will in time become ineffective.

In previous research, a team of researchers in Cambridge identified an isolate of MRSA (a sample grown in culture from a patient’s infection) that showed susceptibility to penicillin in combination with clavulanic acid. Clavulanic acid is a beta-lactamase inhibitor, which prevents the beta-lactamase enzyme destroying penicillin; it is already used as a medicine to treat kidney infections during pregnancy.

In a study published today in Nature Microbiology, a team of scientists from the UK, Denmark, Germany, Portugal, and USA used genome sequencing technology to identify which genes make MRSA susceptible to this combination of drugs. They identified a number of mutations (changes in the DNA sequence) centred around a protein known as a penicillin-binding protein 2a or PBP2a.

PBP2a is crucial to MRSA strains as it enables them to keep growing in the presence of penicillin and other antibiotics derived from penicillin. Two of these mutations reduced PBP2a expression (the amount of PBP2a produced), while two other mutations increased the ability of penicillin to bind to PBP2a in the presence of clavulanic acid. Overall the effect of these mutations means that a combination of penicillin and clavulanic acid could overcome the resistance to penicillin in a proportion of MRSA strains.

The team then looked at whole genome sequences of a diverse collection of MRSA strains and found that a significant number of strains – including USA300 clone, the dominant strain in the United States – contained both mutations that confer susceptibility. This means that one of the most widespread strains of MRSA-causing infections could be treatable by a combination of drugs already licensed for use.

Using this knowledge, the researchers used a combination of the two drugs to successfully treat MRSA infections in moth larvae and then mice. Their next step will be to conduct the further experimental work required for a clinical trial in humans.

Dr Mark Holmes from the Department of Veterinary Medicine at the University of Cambridge, a senior author of the study, says: “MRSA and other antibiotic-resistant infections are a major threat to modern medicine and we urgently need to find new ways to tackle them. Developing new medicines is extremely important, but can be a lengthy and expensive process. Our works suggests that already widely-available medicines could be used to treat one of the world’s major strains of MRSA.”

First author Dr Ewan Harrison, from the Wellcome Sanger Institute and the University of Cambridge, adds: “This study highlights the importance of genomic surveillance – collecting and sequencing representative collections of bacterial strains. By combining the DNA sequencing data generated by genomic surveillance with laboratory testing of the strains against a broad selection of antibiotics, we may find other unexpected chinks in the armour of antibiotic-resistant bacteria that might give us new treatment options.”

The research was funded by the Medical Research Council (MRC), Wellcome and the Department of Health.

Dr Jessica Boname, Head of Antimicrobial Resistance at the MRC, says: “This study demonstrates how a mechanistic understanding of resistance and access to clinical data can be used to find new ways to contain and control infections with existing resources.”

Reference
Harrison, EM et al. Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus. Nature Microbiology; 24 June 2019; DOI: 10.1038/s41564-019-0471-0

I have always loved the great outdoors and I was lucky enough to grow up on a working family farm. At my state school, I enjoyed science, but it all seemed a bit detached from the real world. Earth Sciences is great because it uses all the sciences to better understand our planet (and others!). I did my undergraduate degree at the University of Oxford in the Earth Sciences Department. I then spent a year doing an MSc in Mining Geology at the Camborne School of Mines in Cornwall, before coming to Cambridge for my PhD.

If you find something intriguing or want to ask questions about how something works, then you’re a scientist. Science is about exploring new frontiers, finding out something brand new. Science doesn’t care about your gender identity. So even if you don’t know anyone like you, who has followed the career you want or taken the subject you want to study at A-level, it doesn’t matter, follow what you love and help discover something new.

I am researching the physical behaviour of emulsions in porous media. While emulsions are widely studied in the petroleum industry, carbon sequestration and food science, my interest lies in how these liquids behave during the evolution of large bodies of molten rock trapped beneath the Earth’s surface. As magmas cool and solidify in the Earth’s crust, they can split into two immiscible liquids – one silica-rich and one iron-rich. The different physical properties of these liquids mean that they may separate from each other, comparable to vinegar mixed with oil. This has important implications for the chemical evolution of the magma and hence the development of related ore deposits and the style (explosivity) of volcanic eruptions.

I combine experiments, geochemistry and nanoscale imaging techniques to quantify the physical behaviour of emulsions in magma. By understanding how emulsions form and migrate, we can gain insight into ore deposit formation and location. The igneous petrology community in the Department of Earth Sciences is a world-leading group of scientists, and it is fantastic to have the opportunity to discuss ideas, hear about the latest petrology research and learn from such a group.

I have a number of very different projects, which makes every day rather different. Today I finished cutting up 84 rocks with a circular saw. I collected these on a six-week field trip to east Greenland last summer. I am processing these rocks to find out their chemistry and origin.

Last year I spent a couple of months at the University of Liege in Belgium, to conduct experiments that involved heating powdered rock to 1100 degrees Celsius and then ‘freezing’ it at different temperatures. In between trips away, I analyse different rock samples using lab equipment in the Department of Earth Sciences and then spend time processing the data using a variety of software. In Earth Sciences, we work with limited datasets, because you can’t sample the whole planet, so we have to make interpretations from our data. The first time my work showed something new was a really exciting moment – I finally felt like a ‘proper’ scientist!

During fieldwork in east Greenland I camped 400 km away from civilisation.  I spent five weeks with five other scientists in a truly spectacular environment, with stunning iceberg-filled fjords, fantastic wildlife, dramatic mountains and glacial eroded rocks with no vegetation: perfect for geologists. It was a great experience, working in the field, making observations, discussing and refining hypotheses; a really nice collaborative approach to science!

Read more about Victoria and her research at her blog. 

Cambridge University has the highest number of new members of any institution within Europe. Five University of Cambridge researchers are among the 48 scientists from 17 countries elected:

• Professor Sadaf Farooqi – Wellcome-Medical Research Council (MRC) Institute of Metabolic Science
• Dr Fanni Gergely – Cancer Research UK Cambridge Institute
• Professor Paul Lehner – Department of Medicine and the Cambridge Institute for Medical Research
• Professor Lalita Ramakrishnan – Department of Medicine and the MRC Laboratory of Molecular Biology
• Professor Nicole Soranzo – Department of Haematology and Wellcome Sanger Institute

In addition, Dr Garib Murshudov from the MRC Laboratory of Molecular Biology has also been elected.

EMBO is an organisation of more than 1800 leading researchers in Europe and around the world, whose mission is to promote excellence in the life sciences in Europe and beyond. The major goals of the organisation are to support talented researchers at all stages of their careers, stimulate the exchange of scientific information and help build a research environment where scientists can achieve their best work.

“EMBO Members are excellent scientists who conduct research at the forefront of all life science disciplines, ranging from computational models or analyses of single molecules and cellular mechanics to the study of higher-order systems in development, cognitive neuroscience and evolution,” says EMBO Director Maria Leptin.

“We’re very honoured to have been elected as members of EMBO,” says Professor Farooqi. “This is great recognition for the excellent science taking place across our city, particularly on the Cambridge Biomedical Campus. We are proud of the role we play in European science and look forward to continuing to work in partnership with colleagues across the continent.”

A lack of clarity on government and school policies on mental health and bereavement has led to “confusion and disagreement” on the forms of support schools should offer, says the study, which was conducted for the child bereavement charity Winston’s Wish.

Researchers led by Professor Colleen McLaughlin found a “random approach” among schools, with students reporting receiving “only little or no help at all” following the death of a parent or sibling, and academic pressures monopolising the resources available.

Teachers feel ill-equipped

Although schools recognise bereavement as a high priority, teachers say they feel ill-equipped to offer support to bereaved children, even avoiding intervention through fear of doing more harm than good.

Consequences of parental loss can include mental and physical health problems, as well as lower educational attainment. Yet evidence suggests in many cases this can be mitigated by well-managed school support, at a time when a child’s family, also coping with grief, may not be able to provide the consistent support needed.

One parent dies in the UK every 22 minutes. These parents leave behind around 41,000 dependent children a year, which is more than 100 newly bereaved children each day.

The new study, Consequences of childhood bereavement in the context of the British school system, brings together a wealth of research about children who have lost a mother, father or sibling before the age of 18, with a specific focus on support from school.

“Profound effects” of loss

The effects of losing a loved one are profound for children, the researchers found, with consequences for mental and physical health but also social and educational impacts, including an increased risk of under-achieving or even dropping out of school.

Psychological reactions include fear, helplessness, anxiety, anger, lower self- esteem and insomnia. While these are normal responses to the profound distress caused by the death of a parent or sibling, the support available to children immediately after a death appears to have a strong impact on their mental health longer term, research shows.

Bereavement can also make children particularly vulnerable socially, the study shows, with those from disadvantaged homes not only at increased risk of losing a loved one but already facing tougher social challenges. Having someone to talk to is vital for children and adolescents following a loss, yet one fifth of bereaved participants studied reported not having talked to anyone – a trend that correlated with an increased risk of being bullied, participating in bullying or assaults.

Schools well-placed to support

Strong social networks are key in reducing the negative effects of child bereavement, researchers found, and UK and international experts agree that schools are particularly well-suited to offer support. “Schools often already understand the needs of the individual student and are one of the arenas where children spend most of their waking hours,” says the study.

Exploring how the current British school system deals with bereavement, researchers found a lack of clarity on governmental and school policies on mental health and bereavement, leading to “both confusion and disagreement on the forms of support schools should offer and the extent of that support”. This had led to a “somewhat random approach”.

While a small number of schools have a “planned, managed and holistic response to bereavement”, most do not, and staff “often feel isolated when facing issues related to emotional wellbeing”.

Academic pressures

The “highly pressured” climate in English schools, with a focus on academic outcomes eating up time and resources, made it harder to give time and attention to vulnerable pupils, researchers found. Yet the opportunity to “share difficult thoughts” with someone helped build children’s resilience, directly reducing the difficulties they would experience and the potential for high-risk behaviour.

Professor McLaughlin said: “Our review of research reinforces that grief itself is not an illness. The path that a child takes after the death of a parent or sibling is dependent on the context and multiple aspects. Some pathways make young people very vulnerable, while others do not. Support in the environment is vital, and schools are key in this.

“Young people want schools to acknowledge the bereavement but also to provide a safe space to continue as normally as possible or to have special attention – depending on the child. Teachers want to help badly but space to discuss how to respond and to form a process is being pushed out. They too are asking for help.

“There is a need for a holistic integrated response from schools, and it’s very important that young people are listened to as part of that process.”

Memories of bereavement

Faculty of Education researchers have also gathered the experiences of adults who lost parents and siblings as children. Their moving account, published today in a separate report, Voices of adults bereaved as children, reinforces the message that meaningful support is important in the aftermath of bereavement and that schools are key in providing it.

On interviewee recalled: “I just heard my father, sort of, scream in a really animal sort of way. It was a sound that I’d never heard before and even now I feel the sound physically in my body and that’s what it was like for me as a child. … It was just like being stabbed all over my body. I just felt this, sort of, physical pain and I kind of knew, although I didn’t know, I knew from this awful sound that I heard that my mother had died.”

Another said: “I think if I just dealt with it, sooner in a way, especially when I was younger… if I’d have spoken about it …and in secondary school, I mean I got through it, but when I think back it was a horrible time.”

Winston’s Wish is calling on all schools in the UK to develop a bereavement plan. The charity also urges the schools inspectorate Ofsted to ensure that the revised Inspection Framework takes account of the impact of bereavement on children and young people’s lives, and proposes that all trainee teachers receive core bereavement training.

It has developed a free downloadable guide to supporting bereaved children. It offers guidance on creating a bereavement policy and a procedure for when there is a death in the school community. The charity’s freephone national helpline is also available for teachers to discuss and seek advice and guidance about specific cases.

The free guide for schools and the schools strategy document can be downloaded at www.winstonswish.org/schools

The findings, which draw on interviews conducted remotely through secure apps with academics and students still active in Syria, paint a devastating picture of the impact of the war on all aspects of university life. Consequences range from the destruction of facilities and terrorising presence of security forces on campus to the forced displacement of students and faculty members and near disappearance of research.

Syrian Higher Education post-2011: Immediate and Future Challenges, published today, was commissioned by the Council for At-Risk Academics (Cara), a British charity that helps academics in danger or forced exile, and authored by Professor Colleen McLaughlin with Jo-Anne Dillabough, Olena Fimyar, Zeina Al-Azmeh and Mona Jebril of the Faculty of Education at Cambridge.

A second complementary study out today, The State of Higher Education in Syria pre-2011, also led by Professor McLaughlin and commissioned jointly by Cara and the British Council, provides an overview of the sector before the outbreak of war.

The conflict in Syria has generated the 21st century’s worst humanitarian crisis, with as many as 300,000 Syrians killed and half the population displaced since it began in 2011. Previously, Syria boasted one of the Middle East’s largest and most well-established higher education systems. Not only has the war decimated the university system within the country, but the refugees who have fled are estimated to include 2,000 university professionals and at least 100,000 university-qualified students.

The new report identifies three clear and damaging trends in the Syrian higher education system, many elements of which existed prior to 2011 but all exacerbated by the conflict. Most fundamental is the heightened politicisation of the sector through a variety of means, many involving violence. ‘These include corrupt governance structures, the militarisation of students and university practices, and a much stronger security apparatus leading to the fragmentation and/or complete breakdown of HE,’ the study says.

Human rights violations including detention, patronage, disappearances, displacement and murder are changing the demographic make-up of higher education, it adds, and have led to the social distrust of HE institutions as capable of educating students into the future and the targeting of academics as a particular threat.

One academic interviewed for the study said: “In 2012 I heard from my colleagues in our laboratory that there were soldiers who came to our university, broke down the doors, destroyed everything and hit everybody there because they had protested against the regime”. Another recalled: “One of the professors was dragged away by two security officials in front of the students. That professor was taken to prison and charged because of his political views.”

The general atmosphere within universities was of pervasive fear, in which ‘anyone working at the university is stopped from communicating with anyone outside,’ a third interviewee reported.

Meanwhile, political realignment has become a major obstacle to broad forms of internationalisation and collaboration – the lifeblood of higher education. Regime-controlled universities have had to curtail their links with Western universities, the researchers found, while reinforcing collaboration with countries supportive of the regime, including Russia, Iran and China.

A second trend identified by researchers was the academic impact of the civil war, including curriculum stagnation and the disappearance of research. “The conflict has resulted in massive losses of both HE expertise and HE infrastructure,” says the study, with already-limited university funding diverted towards the conflict and public spending on higher education per head well below the OECD average.

Government control over the content and delivery of curricula has increased in areas controlled by President Bashar al-Assad’s regime, and there is more dependence on rote learning and outdated textbooks. Teaching quality has fallen as experienced qualified staff are lost and replaced by untrained recent graduates, and reports of bribery, cheating and false certification are rife, with corruption “threatening the integrity of HE”.

Research, already limited pre-2011, has “all but disappeared”, driven out by lack of funding and the near-impossibility of field research, the study says.

The third and final trend highlighted in the report is the impact of the conflict on students’ experiences. While access has increased as admission requirements have been lowered to counter lower applications post-2011, attrition rates have “soared” because of personal safety fears, poverty, fear of detention and internal displacement. Education quality has diminished as funding falls, with staff often unavailable and buildings unusable, coupled with disruption to water and power.

In a series of recommendations, the report calls for action from the United Nations, NGOs and the broader international community to depoliticise Syrian higher education and develop and implement “high standards of academic freedom and associated forms of accountability”. While it is important that university students and staff should be kept safe, national security personnel should be withdrawn from campuses and replaced with civilian security personnel trained in conflict reduction and peace-building approaches, the study says.

International partnerships with other Middle Eastern, Western and European universities should be developed. “Standards of transparency, autonomy, freedom and cultural and political pluralism … will be crucial to any post-conflict Syrian HE sector,” researchers conclude.

The report’s findings were drawn from existing academic research and “grey” literature such as news and NGO reports, together with 117 remote interviews with university staff and students still in Syria conducted by compatriot academics in exile, focus group discussions and personal testimonies from 19 Syrian academics living in exile in Turkey.

Professor McLaughlin said: “The key researchers here were the Syrian displaced academics CARA was working with. This collaborative research project was challenging to undertake given the context. The results are important, and so is this way of collaborating. CARA’s work to support Syrian displaced academics is vital and we need to remember and honour their work as well as continue to support research into the reality of Syrian higher education.”

Stephen Wordsworth, Executive Director of Cara, said: “Cara’s regionally-based Syria Programme provides opportunities for Syrian academics in exile to work collaboratively with their counterparts in UK universities and elsewhere, to maintain and develop their skills and experience in preparation for the day when they can return home to help re-build the system of higher education in that country.

“A separate Syria Programme Report examined the state of higher education in Syria before 2011; today’s new study shows very clearly the damage that has been inflicted since then, and what needs to be done to start to put things right again.  We are immensely grateful to all the Syrian academics who contributed, and to Colleen and her team for their inspirational leadership of the project.”

Alcohol use is one of the biggest risk factors for social and physical harm and has been linked to the development of diseases including cancer, diabetes, and liver and heart disease.

Even though the legal age to buy alcohol is 18 years and above in most countries, the 2015 European School Survey Project on Alcohol and Other Drugs found that almost half of 15–16-year-old students had consumed alcohol and 8% had been drunk by the age of 13.

Exposure to alcohol starts from an early age: children as young as two years old become aware of alcohol and are able to distinguish alcoholic from non-alcoholic drinks. From age four on, children start to understand that alcohol is usually restricted to adults and consumed in specific situations. Many studies have connected the parent’s behaviour and the home environment with children’s alcohol use, but it is still unclear how parental attitudes influence their children’s behaviour.

In a study published today in the journal Addiction, Mariliis Tael-Oeren and colleagues at Cambridge’s Behavioural Science Group and the School of Health Sciences at the University of East Anglia (UEA) found that children whose parents had less restrictive attitudes towards their child’s alcohol use were more likely to start drinking alcohol than their peers. They also drank – and got drunk – more frequently.

The findings come from a review of published articles examining parent-child pairs and the relationship between parental attitudes and their child’s alcohol use. A review enables researchers to combine data from a large number of studies, sometimes with conflicting findings, to arrive at a more robust finding. The researchers pooled information from the 29 most relevant articles and analysed all the relevant information, which included data from almost 16,500 children and more than 15,000 parents in the US and Europe.

Mariliis Tael-Oeren, PhD student and lead author for the study, says: “Our study suggests that when parents have a lenient attitude towards their children drinking alcohol, this can lead to their child drinking more frequently – and drinking too much.

“Although the data was based on children and their parents in the US and Europe, we expect that our findings will also apply here in the UK.”

Ms Tael-Oeren and colleagues also found a mismatch between what children think is their parent’s attitude towards them drinking and what the parent’s attitude actually is. Children were no more likely to start drinking alcohol if they perceived their parent to have a lenient attitude, but once they had started drinking, they were more likely to drink often.

“This mismatch doesn’t mean that children perceive parental attitudes completely differently from their parents,” explains Ms Tael-Oeren. “Instead, it could be that their perceptions are skewed towards thinking their parents have more lenient attitudes. This could be because their parents haven’t expressed their attitudes in a way that the children really understand.”

“Alcohol use can be problematic, particularly among young people. It’s important that children understand the short and long term consequences of drinking. If parents don’t want their children to drink, then our study suggests they need to be clear about the message they give out.”

Senior author Professor Stephen Sutton says that social norms could lead to confusion among children. “Alcohol use is influenced by a variety of factors, including attitudes and social norms. If the social norm supports parents introducing alcohol to children, children might mistakenly assume that their parents are more lenient, even when this is not the case.”

Dr Felix Naughton, from UEA’s School of Health Sciences, adds: “Uncovering this mismatch in perceptions is important as it may have implications for parenting programmes designed to support families in reducing childhood alcohol use and indeed for parents who just want to know what they can do to protect their children.”

The study was funded by the Archimedes Foundation.

Reference
M Tael-Öeren, F Naughton, S Sutton. The relationship between parental attitudes and children’s alcohol use: A systematic review and meta-analysis. Addiction; 12 June 2019; DOI: 10.1111/add.14615

In the context of Brexit, the authors say it is vital that UK negotiators seeking new trade agreements are equipped with a solid understanding of manufacturing’s importance to the economy.

The report, ‘Inside the Black Box of Manufacturing’ by Dr Jostein Hauge and Dr Eoin O’Sullivan from Cambridge’s Institute for Manufacturing, was carried out for the Department for Business, Energy and Industrial Strategy (BEIS). The authors say that the current value placed on manufacturing activity is based on outdated and inaccurate methods of counting and that the economic value of manufactured goods increasingly depends on activities that are officially categorised as belonging to other sectors of the economy.

“It is essential that policymakers have accurate information on the size of manufacturing sectors in order to develop internationally competitive industrial strategy,” said O’Sullivan. “In particular, policymakers need to be able to measure manufacturing in a way that better reflects how firms actually organise themselves into value networks.”

“An implication of our study is that if the way manufacturing-related activities are counted does not change, the UK could be missing significant opportunities to build world-leading industries,” said Hauge. “It is also critical that post-Brexit international trade negotiators are equipped with a more accurate understanding of the value of these industries and in particular the potential economic impact of companies moving manufacturing operations away from the UK.”

The report discusses how manufacturing is defined, and what activities are currently included or excluded from how it is counted in the economy, highlighting why its value is being underestimated.

The manufacturing sector plays a significant role in the UK economy. As measured in the national accounts, it provides over 2.7 million jobs, makes up 49% of UK exports, and contributes 66% of all UK R&D business expenditure. However, manufacturing’s contribution to the UK economy – about 9% of GDP – may seem dwarfed by services, which make up 70% of UK GDP.

But according to the report, this is misleading. Manufacturing may in fact be significantly higher in economic contribution and underestimating it could have serious implications for national decision-making.

“It is essential that we properly understand the size and nature of the UK manufacturing sector as well as the value of industries to the UK in order to develop an internationally competitive industrial strategy,” said Clare Porter, Head of Manufacturing the Department for Business, Energy and Industrial Strategy. “Official statistics do not provide the full picture of the role of UK manufacturing in supporting national economic competitiveness and growth. In particular, the official manufacturing statistics do not include the additional value added or jobs generated by services across manufacturing value chains. Many of these services would not thrive, or even exist, without UK-based manufacturing. In fact, many of these services, in particular, technical and professional ones, require deep knowledge and sophisticated capabilities related to the manufacturing activities they support.”

The report explains that the current system of industry classification is out of date, and a range of manufacturing-related services are excluded from the manufacturing category. These are mostly technical services that require sector-specific technical knowhow, like R&D, industrial design, analysis, and testing. Additionally, there are professional service providers in areas such as intellectual property and consultancy that are increasingly tailoring their needs to specific manufacturing industries.

“This report is a clarion call for politicians of all parties to update their understanding and recognise the central importance of manufacturing not only to local regions but to the wider UK economy as well,” said Seamus Nevin, Chief Economist at Make UK. “An increasingly outdated understanding of what modern manufacturing actually is means policymakers have neglected the sector in the misguided belief that services, not manufacturing, is where the future potential for innovation and productivity growth lies. The Government has set out a modern industrial strategy which will be at the centre of the UK economy post-Brexit.

“It is now essential that there is cross-party support to deliver on this to ensure we meet the new technological challenges of digitisation, as well as the societal challenges to which manufacturing, science and engineering will be at the heart of solving.”

The team, led by the University of Cambridge and King’s College London, found that a molecule once thought only to exist inside cells for the purpose of repairing DNA is also responsible for hardening of the arteries, which is associated with dementia, heart disease, high blood pressure and stroke.

There is no current treatment for hardening of the arteries, which is caused by build-up of bone-like calcium deposits, stiffening the arteries and restricting blood flow to organs and tissues.

Supported by funding from the British Heart Foundation, the researchers found that poly(ADP ribose), or PAR, a molecule normally associated with DNA repair, also drives the bone-like calcification of arteries.

Additionally, using rats with chronic kidney disease, the researchers found that minocycline – a widely-prescribed antibiotic often used to treat acne – could treat hardening of the arteries by preventing the build-up of calcium in the circulatory system. The study, the result of more than a decade of fundamental research, is published in the journal Cell Reports.

“Artery hardening happens to everyone as they age, and is accelerated in patients on dialysis, where even children develop calcified arteries. But up until now we haven’t known what controls this process and therefore how to treat it,” said Professor Melinda Duer from Cambridge’s Department of Chemistry, who co-led the research as part of a long-term collaboration with Professor Cathy Shanahan from King’s College London.

“This hardening, or biomineralisation, is essential for the production of bone, but in arteries it underlies a lot of cardiovascular disease and other diseases associated with ageing like dementia,” said Shanahan. “We wanted to find out what triggers the formation of calcium phosphate crystals, and why it seems to be concentrated around the collagen and elastin which makes up much of the artery wall.”

In earlier research, Duer and Shanahan had shown that PAR – normally associated with the repair of DNA inside the cell – can in fact exist outside the cell and is the engine of bone production. This led the researchers to hypothesise that PAR may also play a role in biomineralisation. In addition, PARP1 and PARP2, the dominant PAR-producing enzymes, are expressed in response to DNA damage and oxidative stress, processes which are associated with both bone and vascular calcification.

“We could see signals from bone that we couldn’t explain, so we looked for molecules from first principles to figure it out,” said Duer.

“I’d been thinking for years that hardening of the arteries was linked to DNA damage, and that DNA damage is a pathway switched on by many agents including smoking and lipids,” said Shanahan. “When this pathway is switched on, it drives the pathologies associated with ageing. If enough damage is present, the arteries will eventually reflect it.”

Using NMR spectroscopy, the researchers found that when the cells become stressed and die, they release PAR, which binds very strongly to calcium ions. Once released, the PAR starts mopping up calcium into larger droplets which stick onto the components in artery walls that give the artery its elasticity, where they form ordered crystals and solidify, hardening the arteries.

“We never would have predicted that it was caused by PAR,” said Duer. “It was initially an accidental discovery, but we followed it up – and it’s led to a potential therapy.”

Having discovered the links between DNA damage, PAR, bone and artery calcification, the researchers then looked into a way of blocking this pathway through the use of a PARP inhibitor.

“We had to find an existing molecule that is cheap and safe, otherwise, it would be decades before we would get a treatment,” said Shanahan. “If something has already been shown to be safe in humans, the journey to the clinic can be much faster.”

Working together with Cycle Pharmaceuticals, a Cambridge-based company, the researchers identified six known molecules that they thought might inhibit the PARP enzymes. Detailed experiments with these showed that the antibiotic minocycline was highly effective in preventing hardening of the arteries.

“It’s been 12 years of basic research to get to this point,” said Duer. “We set out with absolutely no expectation of finding a potential treatment – there is no treatment currently and nobody would have believed us if we had said at that point we were going to cure hardening of the arteries.”

The technology has been patented and has been licensed to Cycle Pharmaceuticals by Cambridge Enterprise, the University’s commercialisation arm. The researchers are hoping to carry out a proof of principle trial in patients in the next 12 to 18 months.

“Blood vessel calcification is a well-known risk factor for several heart and circulatory diseases, and can lead to high blood pressure and ultimately, a life-threatening heart attack,” said Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation. “Now, researchers have shown how calcification of the walls of blood vessels takes place, and how the process differs from normal bone formation. By doing so, they have been able to identify a potential treatment to reduce blood vessel calcification without any adverse effects on bone. This type of treatment would benefit many people, and we eagerly await the results of the anticipated clinical trials looking at whether this drug lives up to its early promise.”

Reference:
Karin H. Müller et al. ‘Poly(ADP ribose) links the DNA damage response and biomineralization.’ Cell Reports (2019). DOI: 10.1016/j.celrep.2019.05.038

The researchers, from the Universities of Cambridge and Oxford, applied climate and ecological modelling to illustrate how the distribution of major bird groups is linked to climate change over millions of years. However, while past climate change often occurred slowly enough to allow species to adapt or shift habitats, current rates of climate change may be too fast for many species, putting them at risk of extinction. The results are reported in Proceedings of the National Academy of Sciences.

“Palaeontologists have documented long-term links between climate and the geographic distributions of major bird groups, but the computer models needed to quantify this link had not been applied to this question until now,” said Dr Daniel Field from Cambridge’s Department of Earth Sciences, the paper’s co-lead author.

For the current study, the researchers looked at ten bird groups currently limited to the tropics, predominantly in areas that were once part of the ancient supercontinent of Gondwana (Africa, South America and Australasia). However, early fossil representatives of each of these groups have been found on northern continents, well outside their current ranges.

For example, one such group, the turacos (‘banana eaters’) are fruit-eating birds which are only found in the forests and savannahs of sub-Saharan Africa, but fossils of an early turaco relative have been found in modern-day Wyoming, in the northern United States.

Today, Wyoming is much too cold for turacos for most of the year, but during the early Palaeogene period, which began with the extinction of non-avian dinosaurs 66 million years ago, the Earth was much warmer. Over time, global climates have cooled considerably, and the ancestors of modern turacos gradually shifted their range to more suitable areas.

“We modelled the habitable area for each group of birds and found that their estimated habitable ranges in the past were very different from their geographic distributions today, in all cases shifting towards the equator over geological time,” said Dr Erin Saupe from the University of Oxford, the paper’s other lead author.

Saupe, Field and their collaborators mapped information such as average temperature and rainfall and linked it to where each of the bird groups is found today. They used this climatic information to build an ‘ecological niche model’ to map suitable and unsuitable regions for each bird group. They then projected these ecological niche models onto palaeoclimate reconstructions to map potentially-suitable habitats over millions of years.

The researchers were able to predict the geographic occurrences of fossil representatives of these groups at different points in Earth’s history. These fossils provide direct evidence that these groups were formerly distributed in very different parts of the world to where they are presently found.

“We’ve illustrated the extent to which suitable climate has dictated where these groups of animals were in the past, and where they are now,” said Field. “Depending on the predictions of climate change forecasts, this approach may also allow us to estimate where they might end up in the future.”

“Many of these groups don’t contain a large number of living species, but each lineage represents millions of years of unique evolutionary history,” said Saupe. “In the past, climate change happened slowly enough that groups were able to track suitable habitats as these moved around the globe, but now that climate change is occurring at a much faster rate, it could lead to entire branches of the tree of life going extinct in the near future.”

The research was funded in part by the Natural Environment Research Council (NERC).

Reference:
Erin Saupe et al. ‘Climatic shifts drove major contractions in avian latitudinal distributions throughout the Cenozoic.’ PNAS (2019). DOI: 10.1073/pnas.1903866116

The finding was part of a wider study which also discovered 10,000-year-old human remains in another site in Siberia are genetically related to Native Americans – the first time such close genetic links have been discovered outside of the US.

The international team of scientists, led by Professor Eske Willerslev who holds positions at St John’s College, University of Cambridge, and is director of The Lundbeck Foundation Centre for GeoGenetics at the University of Copenhagen, have named the new people group the ‘Ancient North Siberians’ and described their existence as ‘a significant part of human history’.

The DNA was recovered from the only human remains discovered from the era – two tiny milk teeth – that were found in a large archaeological site found in Russia near the Yana River. The site, known as Yana Rhinoceros Horn Site (RHS), was found in 2001 and features more than 2,500 artefacts of animal bones and ivory along with stone tools and evidence of human habitation.

The discovery is published as part of a wider study in Nature and shows the Ancient North Siberians endured extreme conditions in the region 31,000 years ago and survived by hunting woolly mammoths, woolly rhinoceroses, and bison.

Professor Willerslev said: “These people were a significant part of human history, they diversified almost at the same time as the ancestors of modern-day Asians and Europeans and it’s likely that at one point they occupied large regions of the northern hemisphere.”

Dr Martin Sikora, of The Lundbeck Foundation Centre for GeoGenetics and first author of the study, added: “They adapted to extreme environments very quickly, and were highly mobile. These findings have changed a lot of what we thought we knew about the population history of northeastern Siberia but also what we know about the history of human migration as a whole.”

Researchers estimate that the population numbers at the site would have been around 40 people with a wider population of around 500. Genetic analysis of the milk teeth revealed the two individuals sequenced showed no evidence of inbreeding which was occurring in the declining Neanderthal populations at the time.

The complex population dynamics during this period and genetic comparisons to other people groups, both ancient and recent, are documented as part of the wider study which analysed 34 samples of human genomes found in ancient archaeological sites across northern Siberia and central Russia.

Professor Laurent Excoffier from the University of Bern, Switzerland, said: “Remarkably, the Ancient North Siberians people are more closely related to Europeans than Asians and seem to have migrated all the way from Western Eurasia soon after the divergence between Europeans and Asians.”

Scientists found the Ancient North Siberians generated the mosaic genetic make-up of contemporary people who inhabit a vast area across northern Eurasia and the Americas – providing the ‘missing link’ of understanding the genetics of Native American ancestry.

It is widely accepted that humans first made their way to the Americas from Siberia into Alaska via a land bridge spanning the Bering Strait which was submerged at the end of the last Ice Age. The researchers were able to pinpoint some of these ancestors as Asian people groups who mixed with the Ancient North Siberians.

Professor David Meltzer, Southern Methodist University, Dallas, one of the paper’s authors, explained: “We gained important insight into population isolation and admixture that took place during the depths of the Last Glacial Maximum – the coldest and harshest time of the Ice Age – and ultimately the ancestry of the peoples who would emerge from that time as the ancestors of the indigenous people of the Americas.”

This discovery was based on the DNA analysis of a 10,000-year-old male remains found at a site near the Kolyma River in Siberia. The individual derives his ancestry from a mixture of Ancient North Siberian DNA and East Asian DNA, which is very similar to that found in Native Americans. It is the first time human remains this closely related to the Native American populations have been discovered outside of the US.

Professor Willerslev added: “The remains are genetically very close to the ancestors of Paleo-Siberian speakers and close to the ancestors of Native Americans. It is an important piece in the puzzle of understanding the ancestry of Native Americans as you can see the Kolyma signature in the Native Americans and Paleo-Siberians. This individual is the missing link of Native American ancestry.”

Reference: 
Martin Sikora et al. ‘The population history of northeastern Siberia since the Pleistocene.’ Nature (2019). DOI: 10.1038/s41586-019-1279-z

Originally published on the St John’s College website.