The discovery, published in the journalProceedings of the National Academy of Science, calls into question our current understanding of the processes that drive cancers to become transmissible.

Tasmanian devils are iconic marsupial carnivores that are only found in the wild on the Australian island state of Tasmania. The size of a small dog, the animals have a reputation for ferocity as they frequently bite each other during mating and feeding interactions.

In 1996, researchers observed Tasmanian devils in the north-east of the island with tumours affecting the face and mouth; soon it was discovered that these tumours were contagious between devils, spread by biting. The cancer spreads rapidly throughout the animal’s body and the disease usually causes the death of affected animals within months of the appearance of symptoms. The cancer has since spread through most of Tasmania and has triggered widespread devil population declines. The species was listed as endangered by the International Union for Conservation of Nature in 2008.

To date, only two other forms of transmissible cancer have been observed in nature: in dogs and in soft-shell clams. Cancer normally occurs when cells in the body start to proliferate uncontrollably; occasionally, cancers can spread and invade the body in a process known as ‘metastasis’; however, cancers do not normally survive beyond the body of the host from whose cells they originally derived. Transmissible cancers, however, arise when cancer cells gain the ability to spread beyond the body of the host that first spawned them, by transmission of cancer cells to new hosts.

Now, a team led by researchers from the University of Tasmania, Australia, and the University of Cambridge, UK, has identified a second, genetically distinct transmissible cancer in Tasmania devils.

“The second cancer causes tumours on the face that are outwardly indistinguishable from the previously-discovered cancer,” said first author Dr Ruth Pye from the Menzies Institute for Medical Research at the University of Tasmania. “So far it has been detected in eight devils in the south-east of Tasmania.”

“Until now, we’ve always thought that transmissible cancers arise extremely rarely in nature,” says Dr Elizabeth Murchison from the Department of Veterinary Medicine at the University of Cambridge, a senior author on the study, “but this new discovery makes us question this belief.

“Previously, we thought that Tasmanian devils were extremely unlucky to have fallen victim to a single runaway cancer that emerged from one individual devil and spread through the devil population by biting. However, now that we have discovered that this has happened a second time, it makes us wonder if Tasmanian devils might be particularly vulnerable to developing this type of disease, or that transmissible cancers may not be as rare in nature as we previously thought.”

Professor Gregory Woods, joint senior author from the Menzies Institute for Medical Research at the University of Tasmania, adds: “It’s possible that in the Tasmanian wilderness there are more transmissible cancers in Tasmanian devils that have not yet been discovered. The potential for new transmissible cancers to emerge in this species has important implications for Tasmanian devil conservation programmes.”

The discovery of the second transmissible cancer began in 2014, when a devil with facial tumours was found in south-east Tasmania. Although this animal’s tumours were outwardly very similar to those caused by the first-described Tasmanian devil transmissible cancer, the scientists found that this devil’s cancer carried different chromosomal rearrangements and was genetically distinct. Since then, eight additional animals have been found with the new cancer in the same area of south-east Tasmania.

The research was primarily supported the Wellcome Trust and the Australian Research Council, with additional support provided by Dr Eric Guiler Tasmanian Devil Research Grants and by the Save the Tasmanian Devil Program.

For more information about the research into Tasmanian devils, see T is for Tasmanian Devil.

Reference
Pye, RJ et al. A second transmissible cancer in Tasmanian devils. PNAS; 28 Dec 2015

In late 2015 a Cambridge-based nonprofit released the Raspberry Pi Zero, a tiny £4 computer that was a whole £26 cheaper than the original 2012 model. The Zero is not only remarkable for its own sake – a computer so cheap it comes free with a £5.99 magazine – it is also symptomatic of a larger “frugal innovation” revolution that is taking the world by storm.

With the global economy struggling, this is the kind of innovation that could kickstart it in 2016. Empowered by cheap computers such as the Raspberry Pi and other ubiquitous tools such as smartphones, cloud computing, 3D printers, crowdfunding, and social media, small teams with limited resources are now able to innovate in ways that only large companies and governments could in the past. This frugal innovation – the ability to create faster, better and cheaper solutions using minimal resources – is poised to drive global growth in 2016 and beyond.

More than four billion people around the world, most of them in developing countries, live outside the formal economy and face significant unmet needs when it come to health, education, energy, food, and financial services. For years this large population was either the target of aid or was left to the mercy of governments.

More recently, large firms and smaller social enterprises have begun to see these four billion as an enormous opportunity to be reached through market-based solutions. These solutions must, however, be frugal – highly affordable and flexible in nature. They typically include previously excluded groups both as consumers and producers. Bringing the next four billion into the formal economy through frugal innovation has already begun to unleash growth and create unprecedented wealth in Asia, Africa and Latin America. But there’s much, much more to come.

Good news

Take the case of telecommunications. Over the last decade or so, highly affordable handsets and cheap calling rates have made mobile phones as commonplace as toothbrushes. In addition to bringing massive productivity gains to farmers and small businesses – not to mention creating new sources of employment – mobile phones also enable companies to roll out financial, healthcare and educational services affordably and at scale.

Take the case of Safaricom, Vodafone’s subsidiary in Kenya. In 2007 the company introduced M-Pesa, a service that enables anyone with a basic, SMS-enabled mobile phone to send and receive money that can be cashed in a corner shop acting as an M-Pesa agent.

This person-to-person transfer of small amounts of money between people who are often outside the banking system has increased financial inclusion in Kenya in a highly affordable and rapid way. So much so that more than 20m Kenyans now use M-Pesa and the volume of transactions on the system is more than US$25 billion, more than half the country’s GDP. M-Pesa (and services like it) have now spread to several other emerging markets in Africa and Asia.

Similar frugal innovations in medical devices, transport, solar lighting and heating, clean cookstoves, cheap pharmaceuticals, sanitation, consumer electronics and so on, have driven growth in Asia and Africa over the past decade and will continue to do so in the decades to come.

Catching on

Meanwhile the developed world is catching up. Declining real incomes and government spending, accompanied by greater concern for the environment, are making Western consumers both value and values conscious.

The rise of two massive movements in recent years, the sharing economy and the maker movement, shows the potential of frugal innovation in the West. The sharing economy, exemplified by Airbnb, BlaBlaCar and Kickstarter, has empowered consumers to trade spare assets with each other and thus generate new sources of income. The maker movement, meanwhile, features proactive consumers who tinker in spaces such as FabLabs,TechShops and MakeSpaces, designing solutions to problems they encounter.

Square, a small white, square device that fits into the audio jack of a smartphone, using its computing power and connectivity to make credit card payments, is an example of a product that was developed in a TechShop. Launched in 2010, the Square is on track to make US$1 billion in revenue in 2015.

Frugal innovation not only has the power to drive more inclusive growth by tackling poverty and inequality around the world, it is also increasingly the key to growth that will not simultaneously wreck the planet. The big issue at the Paris climate summit was the increasing wedge between the developed and the developing world. On the one hand, the rich countries cannot stop the poor ones from attempting to achieve the West’s levels of prosperity. On the other, however, poor countries cannot grow in the way the West did without wrecking the planet.

The only way to square this circle is to ensure that the growth is sustainable. The need for frugal innovation is therefore all the more vital in areas such as energy generation and use, manufacturing systems that are more local, and a move to a circular economy where companies (and consumers) reduce, reuse and recycle materials in a potentially endless loop.

Never before have so many been able to do so much for so little. Aiding and stimulating this frugal innovation revolution holds the key to driving global growth by employing more people to solve some of the big problems of poverty, inequality and climate change that stalk the planet.

Jaideep Prabhu, Director, Centre for India & Global Business at Cambridge Judge Business School, University of Cambridge

This article was originally published on The Conversation. Read the original article.

The opinions expressed in this article are those of the individual author(s) and do not represent the views of the University of Cambridge.

Inset images: M-Pesa stand (Fiona Bradley); Square readers (Dom Sagolla).

Older than the British Library and the Vatican Library, Cambridge University Library was first mentioned by name in two wills dated March 1416 and its most valuable contents stored in a wooden chest. The library now holds nine million books, journals, maps and magazines – as well as some of the world’s most iconic scientific, literary and cultural treasures.

Its priceless collections include Newton’s own annotated copy of Principia Mathematica, Darwin’s papers on evolution, 3000-year-old Chinese oracle bones, and the earliest reliable text for 20 of Shakespeare’s plays.

But is also home to a bizarre assembly of non-book curiosities, collected over centuries, including a jar of ectoplasm, a trumpet for hearing spirits and a statue of the Virgin Mary, miraculously saved from an earthquake on Martinique.

Since 1710, Cambridge University Library has also been entitled to one copy of each and every publication in the UK and Ireland under Legal Deposit – meaning the greatest works of more than three millennia of recorded thought sit alongside copies of Woman’s Own and the Beano on more than 100 miles of shelves. With two million of its volumes on open display, readers have the largest open-access collection in Europe immediately available to them.

To celebrate the Library’s 600th birthday, a spectacular free exhibition, Lines of Thought, will open on March 11, 2016. Featuring some of Cambridge’s most iconic and best-known treasures, it investigates through six distinct themes how both Cambridge and its collections have changed the world and will continue to do so in the digital era.

As well as the iconic Newton, Darwin and Shakespeare artefacts mentioned above, items going on display include:

• Edmund Halley’s handwritten notebook/sketches of Halley’s Comet (1682)
• Stephen Hawking’s draft typescript of A Brief History of Time
• Darwin’s first pencil sketch of Species Theory and his Primate Tree
• A second century AD fragment of Homer’s Odyssey.
• The Nash Papyrus – a 2,000-year-old copy of the Ten Commandments
• Codex Bezae – 5th New Testament, crucial to our understanding of The Bible.
• A hand-coloured copy of Vesalius’ 1543 De fabrica – the most influential work in western medicine
• A written record of the earliest known human dissection in England (1564)
• A Babylonian tablet dated 2039 BCE (the oldest object in the library)
• The Gutenberg Bible – the earliest substantive printed book in Western Europe (1454)
• The first catalogue listing the contents of the Library in 1424, barely a decade after it was first identified in the wills of William Loryng and William Hunden

As well as Lines of Thought, 2016 will also see dozens of celebratory events including the library’s 17-storey tower being lit up as part of the e-Luminate Festival in February. Cambridge University Library is also producing a free iPad app giving readers the chance to interact with digitised copies of six of the most revolutionary texts held in its collections. The app analyses the context of the six era-defining works, including Darwin’s family copy of On the origin of species, Newton’s annotated copy of Principia Mathematica, and William Tyndale’s translation of the New Testament into English, an undertaking which led to his execution for heresy.

From October 2016, an exhibition featuring some of the University Library’s most unusual curiosities and oddities will replace Lines of Thought as the second major exhibition of the sexcentenary.

Over the past 600 years, Cambridge has accumulated an extraordinary collection of objects, often arriving at the library as part of bequests and donations. Some of the library’s more unusual artefacts include children’s games, ration books, passports, prisoner art, Soviet cigarettes and cigars and an East African birthing stool.

University Librarian Anne Jarvis said: “For six centuries, the collections of Cambridge University Library have challenged and changed the world around us. Across science, literature and the arts, the millions of books, manuscripts and digital archives we hold have altered the very fabric of our understanding. Thousands of lines of thoughts run through them, back into the past, and forward into tomorrow. Our 600th anniversary is a chance to celebrate one of the world’s oldest and greatest research libraries, and to look forward to its future.

“Only in Cambridge, can you find Newton’s greatest works sitting alongside Darwin’s most important papers on evolution, or Sassoon’s wartime poetry books taking their place next to the Gutenberg Bible and the archive of Margaret Drabble. Our aim now, through our Digital Library, is to share as many of these great collections as widely as possible so that anyone, anywhere in the world, can stand on the shoulders of these giants.”

Researchers from Cambridge and Cardiff Universities are developing an origami-like material that could help prevent brain injuries in sport, as part of a programme sponsored in part by American football’s National Football League (NFL).

A number of universities and commercial companies are taking part in the NFL’s Head Health Challenge, which, as one of its goals, aims to develop the next generation of advanced materials for use in helmets and other types of body protection, for sport, military and other applications.

The Cambridge and Cardiff team are working in collaboration with helmet designer and manufacturer Charles Owen Inc, with funding support from the NFL, GE Healthcare, Under Armour and the National Institute of Standards and Technology, to develop and test their material over the next 12 months.

The Head Health Challenge competition is a $20 million collaborative project to develop new and innovative technologies in order to improve early-stage detection of mild traumatic brain injuries and to improve brain protection. The five-year collaboration is aiming to improve the safety of athletes, members of the military and society overall.

“The key challenge for us is to come up with a material that can be optimised for a range of different types of impacts,” said Dr Graham McShane of Cambridge’s Department of Engineering, who is part of the team behind the material. “A direct impact is different than an oblique impact, so the ideal material will behave and deform accordingly, depending on how it’s been hit – what we are looking at is the relationship between the material, geometry and the force of impact.”

In high-impact sports such as American football, players can hit each other with the equivalent of half a ton of force, and in an average game, there can be dozens of these high-impact blocks or tackles. More than 100 concussions are reported each year in the NFL, and over the course of a career, multiple concussions can do serious long-term damage.

The Head Health Challenge has created three separate challenges as part of its program of funding: Challenge I – Methods for Diagnosis and Prognosis of Mild Traumatic Brain Injuries; Challenge II – Innovative Approaches for Preventing and Identifying Brain Injuries; and Challenge III – Advanced Materials for Impact Mitigation. The C³ project is part of Challenge III. The various projects from Challenge III will have their efforts judged in a year’s time by a review panel, with the most promising technology receiving another $500,000 to develop the material further.

The multi-layered, elastic material developed by McShane and his colleagues at Cambridge and Cardiff, called C³, has been designed and tested using a mixture of theoretical and experimental techniques, so that it can be tailored for specific impact scenarios.

C³ has its origins in cellular materials conceived in the Department of Engineering for defence applications, and is based on folded, origami-like structures. It is more versatile than the polymer foams currently used in protective helmets, which are highly limited in terms of how they behave under different conditions.

Structures made from C³ can be designed in such a way that impact energy can be dissipated relatively easily, making it an ideal material to use in protective clothing and accessories.

Dr Peter Theobald, a Senior Lecturer at Cardiff University who is leading on the project, said: “Head injury prevention strategies have remained relatively stagnant versus the evolution of other technologies. Our trans-Atlantic collaboration with Charles Owen Inc. has enabled us to pool our highly relevant skills and expertise in injury prevention, mechanics, manufacturing and commercialisation.”

“This approach has already enabled us to develop C³ which, in the words of our evaluators, presents a potentially ‘game-changing’ material with great promise to better absorb the vertical and horizontal components of an oblique impact. This highly prestigious award provides us with a platform to continue developing C³ towards our ultimate goal of achieving a material that provides a step-change in head health and protection, whilst achieving metrics that ensure commercial viability.”

Inset image: Sample of C³. Credit: Cardiff University.

Adapted from Cardiff University press release. 

Published today in the journal Nature Structural and Molecular Biology, the discovery suggests that many more DNA modifications than previously thought may exist in human, mouse and other vertebrates.

DNA is made up of four ‘bases’: molecules known as adenine, cytosine, guanine and thymine – the A, C, G and T letters. Strings of these letters form genes, which provide the code for essential proteins, and other regions of DNA, some of which can regulate these genes.

Epigenetics (epi – the Greek prefix meaning ‘on top of’) is the study of how genes are switched on or off. It is thought to be one explanation for how our environment and behaviour, such as our diet or smoking habit, can affect our DNA and how these changes may even be passed down to our children and grandchildren.

Epigenetics has so far focused mainly on studying proteins called histones that bind to DNA. Such histones can be modified, which can result in genes being switched on or of. In addition to histone modifications, genes are also known to be regulated by a form of epigenetic modification that directly affects one base of the DNA, namely the base C. More than 60 years ago, scientists discovered that C can be modified directly through a process known as methylation, whereby small molecules of carbon and hydrogen attach to this base and act like switches to turn genes on and off, or to ‘dim’ their activity. Around 75 million (one in ten) of the Cs in the human genome are methylated.

Now, researchers at the Wellcome Trust-Cancer Research UK Gurdon Institute and the Medical Research Council Cancer Unit at the University of Cambridge have identified and characterised a new form of direct modification – methylation of the base A – in several species, including frogs, mouse and humans.

Methylation of A appears to be far less common that C methylation, occurring on around 1,700 As in the genome, but is spread across the entire genome. However, it does not appear to occur on sections of our genes known as exons, which provide the code for proteins.

“These newly-discovered modifiers only seem to appear in low abundance across the genome, but that does not necessarily mean they are unimportant,” says Dr Magdalena Koziol from the Gurdon Institute. “At the moment, we don’t know exactly what they actually do, but it could be that even in small numbers they have a big impact on our DNA, gene regulation and ultimately human health.”

More than two years ago, Dr Koziol made the discovery while studying modifications of RNA. There are 66 known RNA modifications in the cells of complex organisms. Using an antibody that identifies a specific RNA modification, Dr Koziol looked to see if the analogous modification was also present on DNA, and discovered that this was indeed the case. Researchers at the MRC Cancer Unit then confirmed that this modification was to DNA, rather than from any RNA contaminating the sample.

“It’s possible that we struck lucky with this modifier,” says Dr Koziol, “but we believe it is more likely that there are many more modifications that directly regulate our DNA. This could open up the field of epigenetics.”

The research was funded by the Biotechnology and Biological Sciences Research Council, Human Frontier Science Program, Isaac Newton Trust, Wellcome Trust, Cancer Research UK and the Medical Research Council.

Reference
Koziol, MJ et al. Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. Nature Structural and Molecular Biology; 21 Dec 2015

Human pluripotent stem cells for use in regenerative medicine or biomedical research come from two sources: embryonic stem cells, derived from fertilised egg cells discarded from IVF procedures; and induced pluripotent stem cells, where skin cells are ‘reset’ to their original, pluripotent form. They are seen as having promising therapeutic uses in regenerative medicine to treat devastating conditions that affect various organs and tissues, particularly those that have poor regenerative capacity, such as the heart, brain and pancreas.

However, some scientists have been concerned that the cells may not incorporate properly into the body and hence not proliferate or distribute themselves as intended, resulting in tumours. Today’s study suggests that this will not be the case and that stem cells, when transplanted appropriately, are likely to be safe for use in regenerative medicine.

Professor Roger Pedersen from the Anne McLaren Laboratory for Regenerative Medicine at the University of Cambridge, commenting on co-author Victoria Mascetti’s research findings, says: “Our study provides strong evidence to suggest that human stem cells will develop in a normal – and importantly, safe – way. This could be the news that the field of regenerative medicine has been waiting for.”

The best way to test how well stem cells would incorporate into the body is to transplant them into an early-stage embryo and see how they develop. As this cannot be done ethically in humans, scientists use mouse embryos. The gold standard test, developed in Cambridge in the 1980s, involves putting the stem cells into a mouse blastocyst, a very early stage embryo after fertilisation, then assessing stem cell contribution to the various tissues of the body.

Previous research has not succeeded in getting human pluripotent stem cells to incorporate into embryos. However, in research funded by the British Heart Foundation, Victoria Mascetti and Professor Pedersen have shown that it is possible to successfully transplant human pluripotent stem cells into the mouse embryo and that they then develop and grow normally.

Image: Mouse embryo with human pluripotent stem cells (red) incorporated into the brain region

“Stem cells hold great promise for treating serious conditions such as heart disease and Parkinson’s disease, but until now there has been a big question mark over how safe and effective they will be,” explains Professor Pedersen.

Mascetti’s research breakthrough in this new study was to demonstrate that human pluripotent stem cells are equivalent to an embryonic counterpart. Where attempts to incorporate human pluripotent stem cells had failed previously, it was because the stem cells had not been matched to the correct stage of embryo development: the cells needed to be transplanted into the mouse embryo at a later stage than was previously thought (a stage of embryo development known as gastrulation). Once transplanted at the correct stage, the stem cells went on to grow and proliferate normally, to integrate into the embryo and to distribute themselves correctly across relevant tissues.

Ms Mascetti adds: “Our finding that human stem cells integrate and develop normally in the mouse embryo will allow us to study aspects of human development during a window in time that would otherwise be inaccessible.”

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, which helped fund the study, said: “These results substantially strengthen the view that induced pluripotent stem cells from adult tissue are suitable for use in regenerative medicine – for example in attempts to repair damaged heart muscle after a heart attack.

“The Cambridge team has shown definitively that when stem cells are introduced into early mouse embryos under the right conditions, they multiply and contribute in the correct way to all the cell types that are formed as the embryo develops.”

Reference
Victoria L Mascetti and Roger A Pedersen. Human-Mouse Chimerism Validates Human Stem Cell Pluripotency. Cell Stem Cell; 17 Dec 2015

We know we share a common ancestor with Neanderthals, the extinct species that were our closest prehistoric relatives. But what this ancient ancestral population looked like remains a mystery, as fossils from the Middle Pleistocene period, during which the lineage split, are extremely scarce and fragmentary.

Now, researchers have applied digital “morphometrics” and statistical algorithms to cranial fossils from across the evolutionary story of both species, and recreated in 3D the skull of the last common ancestor of Homo sapiens and Neanderthals for the first time.

The “virtual fossil” has been simulated by plotting a total of 797 “landmarks” on the cranium of fossilised skulls stretching over almost two million years of Homo history – including a 1.6 million-year-old Homo erectus fossil, Neanderthal crania found in Europe and even 19th century skulls from the Duckworth collection in Cambridge.

The landmarks on these samples provided an evolutionary framework from which researchers could predict a timeline for the skull structure, or ‘morphology’, of our ancient ancestors. They then fed a digitally-scanned modern skull into the timeline, warping the skull to fit the landmarks as they shifted through history.

This allowed researchers to work out how the morphology of both species may have converged in the last common ancestor’s skull during the Middle Pleistocene – an era dating from approximately 800,000 to 100,000 years ago.

The team generated three possible ancestral skull shapes that corresponded to three different predicted split times between the two lineages. They digitally rendered complete skulls and then compared them to the few original fossils and bone fragments of the Pleistocene age.

This enabled the researchers to narrow down which virtual skull was the best fit for the ancestor we share with Neanderthals, and which timeframe was most likely for that last common ancestor to have existed.

Previous estimates based on ancient DNA have predicted the last common ancestor lived around 400,000 years ago. However, results from the ‘virtual fossil’ show the ancestral skull morphology closest to fossil fragments from the Middle Pleistocene suggests a lineage split of around 700,000 years ago, and that – while this ancestral population was also present across Eurasia – the last common ancestor most likely originated in Africa.

The results of the study are published in the Journal of Human Evolution.

“We know we share a common ancestor with Neanderthals, but what did it look like? And how do we know the rare fragments of fossil we find are truly from this past ancestral population? Many controversies in human evolution arise from these uncertainties,” said the study’s lead author Dr Aurélien Mounier, a researcher at Cambridge University’s Leverhulme Centre for Human Evolutionary Studies (LCHES).

“We wanted to try an innovative solution to deal with the imperfections of the fossil record: a combination of 3D digital methods and statistical estimation techniques. This allowed us to predict mathematically and then recreate virtually skull fossils of the last common ancestor of modern humans and Neanderthals, using a simple and consensual ‘tree of life’ for the genus Homo,” he said.

The virtual 3D ancestral skull bears early hallmarks of both species. For example, it shows the initial budding of what in Neanderthals would become the ‘occipital bun’: the prominent bulge at the back of the skull that contributed to elongated shape of a Neanderthal head.

However, the face of the virtual ancestor shows hints of the strong indention that modern humans have under the cheekbones, contributing to our more delicate facial features. In Neanderthals, this area – the maxillia – is ‘pneumatized’, meaning it was thicker bone due to more air pockets, so that the face of a Neanderthal would have protruded.

Research from New York University published last week showed that bone deposits continued to build on the faces of Neanderthal children during the first years of their life.

The heavy, thickset brow of the virtual ancestor is characteristic of the hominin lineage, very similar to early Homo as well as Neanderthal, but lost in modern humans. Mounier says the virtual fossil is more reminiscent of Neanderthals overall, but that this is unsurprising as taking the timeline as a whole it is Homo sapiens who deviate from the ancestral trajectory in terms of skull structure.

“The possibility of a higher rate of morphological change in the modern human lineage suggested by our results would be consistent with periods of major demographic change and genetic drift, which is part of the history of a species that went from being a small population in Africa to more than seven billion people today,” said co-author Dr Marta Mirazón Lahr, also from Cambridge’s LCHES.

The population of last common ancestors was probably part of the species Homo heidelbergensis in its broadest sense, says Mounier. This was a species of Homo that lived in Africa, Europe and western Asia between 700,000 and 300,000 years ago.

For their next project, Mounier and colleagues have started working on a model of the last common ancestor of Homo and chimpanzees. “Our models are not the exact truth, but in the absence of fossils these new methods can be used to test hypotheses for any palaeontological question, whether it is horses or dinosaurs,” he said.

Reported today in the British Journal of Cancer, the test could enable doctors to monitor the effectiveness of treatments without exposing patients to repeated doses of radiation.

The target of the test is a type of cancer known as germ cell cancer. Germ cells are those cells in the body that go on to develop into sperm and egg cells. Germ cells can develop into tumours – both benign and malignant – particularly in the testes or ovaries, where the cells are normally found. However, occasionally germ cells can get trapped in the wrong part of the body during development and may later turn into brain tumours, for example.

The five year disease-free and overall survival rates for patients with high-risk malignant germ cell tumours remains less than 50%, and so accurate diagnosis and monitoring is crucial to improving outcomes for patients. All of the current tests are expensive, and none are ideal.

The most reliable diagnostic method currently in use is biopsy, where a section of the suspected tumour is extracted surgically and analysed by a pathologist. However, biopsies are prone to sampling errors and so may not be representative of the tumour as a whole. Computerised tomography (CT) scans and magnetic resonance imaging (MRI) also provide useful information but are not diagnostic and do not discriminate between benign and malignant tumours.

The ideal tool for diagnosis would be a non-invasive blood test; however, currently available tests only identify around three in five malignant germ cell tumours, potentially delaying diagnosis and the ability to prioritise patients for surgery. Accurate disease monitoring with routine blood testing is not possible for two in five patients, requiring follow up CT scans with exposure to harmful radiation and an associated increased secondary cancer risk.

“Although relatively rare, childhood germ cell tumours need to be diagnosed accurately and followed up carefully to give us the best chances of treating them,” says Professor Nick Coleman from the Department of Pathology, University of Cambridge. “At the moment, we are not good enough at diagnosing these tumours and monitoring their treatment: we need better, safer and more cost-effective tests.”

In research funded by Sparks charity, Great Ormond Street Hospital Children’s Charity and Cancer Research UK, researchers at the University of Cambridge have developed a test for blood and cerebrospinal fluid samples that looks for a specific panel of four pieces of short genetic code known as microRNAs, which are found in greater quantities in malignant germ cell tumours. The test can distinguish malignant germ cell tumours from benign germ cell tumours and other cancers. The test can be used for diagnosis of malignant germ cell tumours in any part of the body, including the brain.

The test can also be used to check the effectiveness of treatments and, as it is safe and cost-effective, allows for frequent testing to monitor for the recurrence of malignant germ cell tumours.

Dr Matthew Murray from the Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, says: “This test, developed with Dr Emma Bell, a postdoctoral scientist in our laboratory, could be exactly what we need: it could help us diagnose malignant germ cell tumours cheaply, safely and above all, more accurately than current methods. Our next step is to confirm our findings in a large clinical trial and, if this is successful, we hope to see the test in routine use in hospitals in the near future.”

Reference
Murray, MJ, Bell E, et al. A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours. British Journal of Cancer; 15 Dec 2015

A new study shows that if the European Union lifted the pigswill ban imposed following 2001’s foot-and-mouth disease epidemic, and harnessed technologies developed in East Asian countries for ‘heat-treating’ our food waste to safely turn it into pig feed, around 1.8 million hectares of land could be saved from being stripped for grain and soybean-based pig feed production – including over quarter of a million hectares of Brazilian forest and savannah.

While swill-feeding was banned across the EU in 2002 following the foot-and-mouth outbreak – triggered by a UK farmer illegally feeding uncooked food waste to pigs – other countries, such as Japan, responded by creating a highly regulated system for safely recycling heat-treated food waste as animal feed.

Researchers describe the EU ban as a “knee-jerk reaction” that no longer makes sense when East Asian countries have demonstrated that food waste can be safely recycled. The models in the latest study show that pigswill reintroduction would not only decrease the amount of land the EU pork industry requires by 21.5%, but also cut in half the ever-increasing feed costs faced by European pig farmers.

Researchers describe swill as a feed which is commonly used in other parts of the world, one that could save a huge amount of global resources, and provide an environmentally sound recycling solution to the estimated 102.5 million tonnes of food wasted in the EU each year. Over 35% of food waste is now recycled into animal feed in Japan, where swill-fed “Eco-pork” is marketed as a premium product.

“Following the foot-and-mouth disease outbreak, different countries looked at the same situation, the same evidence, and came to opposite conclusions for policy,” said Erasmus zu Ermgassen from the University of Cambridge’s Department of Zoology, who led the study, published today in the journal Food Policy. “In many countries in East Asia we have a working model for the safe use of food waste as pig feed. It is a highly regulated and closely monitored system that recycles food waste and produces low-cost pig feed with a low environmental impact.”

The researchers examined data about the current land use of EU pork, the availability of food waste in the EU, and the quality and quantity of pork produced in feed trials that compared pigswill to grain-based diets, to produce a model of how much land could be saved if the pigswill ban was lifted.

Some 21.5 million tonnes of pork, around 34kg of pork per person, are produced in the EU each year. Livestock production occupies approximately 75% of agricultural land worldwide – with most of this used to produce animal feed. For EU pork, much of the environmental burden stems from the farming of soybean meal, which takes up in excess of 1.2 million hectares of land across South America.

As swill is much cheaper than grain and soybean-based pig feed, reintroducing swill feeding could reduce costs faced by EU pig farmers by 50%, say the researchers.

Most objection to swill feeding in the EU stems from concerns about safety, and the sentiment that feeding human food waste to pigs is unnatural. But zu Ermgassen argues that those concerns are largely based on incorrect assumptions.

“Pigs are omnivorous animals; in the wild they would eat anything they could forage for, from vegetable matter to other animal carcasses, and they have been fed food waste since they were domesticated by humans 10,000 years ago. Swill actually provides a more traditional diet for pigs than the grain-based feed currently used in modern EU systems,” said zu Ermgassen.

“A recent survey found that 25% of smallholder farmers in the UK admit to illegally feeding uncooked food waste to their pigs, so the fact is that the current ban is not particularly safe from a disease-outbreak perspective. Feeding uncooked food waste is dangerous because pigs can catch diseases from raw meat, but a system supporting the regulated use of heat-treated swill does not have the same risks,” he said.

With the demand for meat and dairy products forecast to increase 60% by 2050, reducing the environmental footprint of current systems of meat production will become increasingly critical.

zu Ermgassen points out that economic and environmental concern is driving a reassessment of EU animal feed bans that were put in place in the 2000s, as well as attempts to recycle food waste more effectively. The EU is currently looking into repealing bans on using waste pig and poultry products as fish feed and reintroducing insects as pig and poultry feed.

“The reintroduction of swill feeding in the EU would require backing from pig producers, the public, and policy makers, but it has substantial potential to improve the environmental and economic sustainability of EU pork production. It is time to reassess whether the EU’s blanket ban on the use of food waste as feed is the right thing for the pig industry,” he said.

Erasmus zu Ermgassen’s research is funded by the Biotechnology and Biological Sciences Research Council.

Reference

Erasmus K.H.J. zu Ermgassen, et al. “Reducing the land use of EU pork production: where there’s swill, there’s a way” Food Policy Vol 58 (January 2016). DOI:10.1016/j.foodpol.2015.11.001.

Inset image: “Save Kitchen Waste to Feed the Pigs!” poster from the Imperial War Museums © IWM (Art.IWM PST 14743).

A new ‘periodic table’ of protein complexes, devised by an interdisciplinary team of researchers, provides a unified way to classify and visualise protein complexes, which drive a huge range of biological processes, from DNA replication to catalysing metabolic reactions.

The table, published in the journal Science, offers a new way of looking at almost all known molecular structures and predicting how new ones could be made, providing a valuable tool for research into evolution and protein engineering.

By using the table, researchers are able predict the likely forms of protein complexes with unknown structure, estimate the feasibility of entirely new structures, and identify possible errors in existing structural databases. It was created by an interdisciplinary team led by researchers at the University of Cambridge and the Wellcome Genome Campus.

Almost every biological process depends on proteins interacting and assembling into complexes in a specific way, and many diseases, such as Alzheimer’s and Parkinson’s, are associated with problems in complex assembly. The principles underpinning this organisation are not yet fully understood, but the new periodic table presents a systematic, ordered view on protein assembly, providing a visual tool for understanding biological function.

“We’re bringing a lot of order into the messy world of protein complexes,” said the paper’s lead author Sebastian Ahnert of Cambridge’s Cavendish Laboratory, a physicist who regularly tangles with biological problems. “Proteins can keep combining in these simple ways, adding more and more levels of complexity and resulting in a huge variety of structures. What we’ve made is a classification based on underlying principles that helps people get a handle on the complexity.”

The exceptions to the rule are interesting in their own right, added Ahnert, and are the subject of continuing studies.

“Evolution has given rise to a huge variety of protein complexes, and it can seem a bit chaotic,” said study co-author Joe Marsh, formerly of the Wellcome Genome Campus and now of the MRC Human Genetics Unit at the University of Edinburgh. “But if you break down the steps proteins take to become complexes, there are some basic rules that can explain almost all of the assemblies people have observed so far.”

Ballroom dancing can be seen as an endless combination of riffs on the waltz, fox trot and cha-cha. Similarly, the ‘dance’ of protein complex assembly can be seen as endless variations on dimerization (one doubles, and becomes two), cyclisation (one forms a ring of three or more) and subunit addition (two different proteins bind to each other). Because these happen in a fairly predictable way, it’s not as hard as you might think to predict how a novel protein would form.

Some protein complexes, called homomers, feature multiple copies of a single protein, while others, called heteromers, are made from several different types of proteins. The table shows that there is a very close relationship between the possible structures of heteromers and homomers. In fact, the vast majority of heteromers can be thought of as homomers in which the single protein is replaced by a repeated unit of several proteins. The table was constructed using computational analysis of a large database of protein-protein interfaces.

“By analysing the tens of thousands of protein complexes for which three-dimensional structures have already been experimentally determined, we could see repeating patterns in the assembly transitions that occur – and with new data from mass spectrometry we could start to see the bigger picture,” said Walsh.

“The core work for this study is in theoretical physics and computational biology, but it couldn’t have been done without the mass spectrometry work by our colleagues at Oxford University,” said Sarah Teichmann, Research Group Leader at the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust Sanger Institute. “This is yet another excellent example of how extremely valuable interdisciplinary research can be.”

Reference:
Ahnert SE, et. al. ‘Principles of assembly reveal a periodic table of protein complexes.’ Science (2015). DOI: 10.1126/science.aaa2245

Adapted from an EMBL-EBI press release.

The domestication of the small-seeded cereal millet in North China around 10,000 years ago created the perfect crop to bridge the gap between nomadic hunter-gathering and organised agriculture in Neolithic Eurasia, and may offer solutions to modern food security, according to new research.

Now a forgotten crop in the West, this hardy grain – familiar in the west today as birdseed – was ideal for ancient shepherds and herders, who carried it right across Eurasia, where it was mixed with crops such as wheat and barley. This gave rise to ‘multi-cropping’, which in turn sowed the seeds of complex urban societies, say archaeologists.

A team from the UK, USA and China has traced the spread of the domesticated grain from North China and Inner Mongolia into Europe through a “hilly corridor” along the foothills of Eurasia. Millet favours uphill locations, doesn’t require much water, and has a short growing season: it can be harvested 45 days after planting, compared with 100 days for rice, allowing a very mobile form of cultivation.

Nomadic tribes were able to combine growing crops of millet with hunting and foraging as they travelled across the continent between 2500 and 1600 BC. Millet was eventually mixed with other crops in emerging populations to create ‘multi-crop’ diversity, which extended growing seasons and provided our ancient ancestors with food security.

The need to manage different crops in different locations, and the water resources required, depended upon elaborate social contracts and the rise of more settled, stratified communities and eventually complex ‘urban’ human societies.

Researchers say we need to learn from the earliest farmers when thinking about feeding today’s populations, and millet may have a role to play in protecting against modern crop failure and famine.

“Today millet is in decline and attracts relatively little scientific attention, but it was once among the most expansive cereals in geographical terms. We have been able to follow millet moving in deep history, from where it originated in China and spread across Europe and India,” said Professor Martin Jones from the University of Cambridge’s Department of Archaeology and Anthropology, who is presenting the research findings today at the Shanghai Archaeological Forum.

“These findings have transformed our understanding of early agriculture and society. It has previously been assumed that early agriculture was focused in river valleys where there is plentiful access to water. However, millet remains show that the first agriculture was instead centred higher up on the foothills – allowing this first pathway for ‘exotic’ eastern grains to be carried west.”

The researchers carried out radiocarbon dating and isotope analysis on charred millet grains recovered from archaeological sites across China and Inner Mongolia, as well as genetic analysis of modern millet varieties, to reveal the process of domestication that occurred over thousands of years in northern China and produced the ancestor of all broomcorn millet worldwide.

“We can see that millet in northern China was one of the earliest centres of crop domestication, occurring over the same timescale as rice domestication in south China and barley and wheat in west China,” explained Jones.

“Domestication is hugely significant in the development of early agriculture – humans select plants with seeds that don’t fall off naturally and can be harvested, so over several thousand years this creates plants that are dependent on farmers to reproduce,” he said.

“This also means that the genetic make-up of these crops changes in response to changes in their environment – in the case of millet, we can see that certain genes were ‘switched off’ as they were taken by farmers far from their place of origin.”

As the network of farmers, shepherds and herders crystallised across the Eurasian corridor, they shared crops and cultivation techniques with other farmers, and this, Jones explains, is where the crucial idea of ‘multi-cropping’ emerged.

“The first pioneer farmers wanted to farm upstream in order to have more control over their water source and be less dependent on seasonal weather variations or potential neighbours upstream,” he said. “But when ‘exotic’ crops appear in addition to the staple crop of the region, then you start to get different crops growing in different areas and at different times of year. This is a huge advantage in terms of shoring up communities against possible crop failures and extending the growing season to produce more food or even surplus.

“However, it also introduces a more pressing need for cooperation, and the beginnings of a stratified society. With some people growing crops upstream and some farming downstream, you need a system of water management, and you can’t have water management and seasonal crop rotation without an elaborate social contract.”

Towards the end of the second and first millennia BC larger human settlements, underpinned by multi-crop agriculture, began to develop. The earliest examples of text, such as the Sumerian clay tablets from Mesopotamia, and oracle bones from China, allude to multi-crop agriculture and seasonal rotation.

But the significance of millet is not just in transforming our understanding of our prehistoric past. Jones believes that millet and other small-seeded crops may have an important role to play in ensuring future food security.

“The focus for looking at food security today is on the high-yield crops, rice, maize and wheat, which fuel 50% of the human food chain. However, these are only three of 50 types of cereal, the majority of which are small-grained cereals or “millets”. It may be time to consider whether millets have a role to play in a diverse response to crop failure and famine,” said Jones.

“We need to understand more about millet and how it may be part of the solution to global food security – we may have a lot still to learn from our Neolithic predecessors.”

Inset images: Martin Jones with millet in North China (Martin Jones); Inner Mongolian millet farmer in Chifeng (Martin Jones).

Salt Lake City’s preservation of the Wasatch watershed is an important model for protecting urban water sources through land use regulation and conservation, which could have important implications for preserving future water supplies against the effects of climate change in the American West, according to a new study. This example is currently absent from academic literature on ecosystem services, meaning that conservation discussions are instead dominated by models that focus on financial, ‘market-based’ incentives to protect watershed areas, which the researchers argue could be inappropriate in many circumstances.

The most prevalent model for water resource preservation is that of New York City’s Catskills/Delaware watershed, which is based on upstream resource users being paid to avoid harmful practices that might affect water flows and water quality, typically by beneficiaries who are downstream. These ‘market-based’ approaches (also known as Payments for Watershed or Ecosystem Services) have been widely promoted, but risk neglecting alternative approaches that do not always require monetary transactions to improve environmental outcomes.

In contrast, Salt Lake City’s management strategy allows regulated use of the watershed area for public recreation (unlike other forested catchments in the US where public access is prohibited to preserve water resources). In the Wasatch case, this means that the upstream catchment remains accessible, including for high impact uses such as skiing and mountain biking. Researchers argue that it is vital to consider these alternative strategies for solving the increasing water scarcity in the American West.

“While regulatory exclusion is often thought of as the only viable alternative to market-based incentives in managing ecosystem services, the management of the Wasatch watershed provides a third, yet under-recognised, successful conservation strategy for water resources,” says Libby Blanchard, lead author of the study from the University of Cambridge’s Department of Geography.

“The dominance of the Catskills example in discussions of watershed protection provides an unduly limited, and historically incomplete, perspective on interventions to secure water resources, and limits policy discussions about alternative conservation approaches,” she adds.

In the American West, unprecedented droughts have caused extreme water shortages. The current drought in California and across the West is entering its fourth year, with precipitation and water storage reaching record low levels. Droughts are ranked second in the US in terms of national weather-related economic impacts, with annual losses just shy of $9 billion. With water scarcity likely to increase due to advancing climate change, the economic and environmental impacts of drought are also likely to get worse.

“The chances of a ‘megadrought’ – one that lasts for 35 years or longer – affecting the Southwest and central Great Plains by 2100 are above 80% if climate change projections are not mitigated,” says Blanchard. “As the West faces more frequent and severe droughts, the successful protection of watersheds for the ecosystem services of water capture, storage, and delivery they provide will be increasingly important.”

“The sufficient and effective protection of watersheds will become more challenging, so awareness of alternative, successful strategies is critically important,” adds Bhaskar Vira, co-author of the study also from Cambridge’s Department of Geography. “The management of the Wasatch is one such strategy that should be more widely recognised amongst policymakers and researchers alike seeking effective solutions to water scarcity.”

The economic and instrumental value of the Wasatch watershed was noticed by Salt Lake City’s government as early as the 1850s, when the first legislation to protect the city’s natural resources was passed. Salt Lake City uses two tools to protect its watershed: purchasing land for conservation, and regulating land use by restricting a variety of activities within the watershed such as cattle grazing. Recreation is not altogether restricted, but is negotiated with the local community to allow public use. The Uinta-Wasatch-Cache National Forest is one of the most heavily visited national forests in the US, with 7 million annual visitors.

“Salt Lake City has been able to preserve the natural capital that protects its watershed while allowing recreational use. The preservation of the watershed actually boosts recreation, providing visitors with natural landscapes and unadulterated settings for mountain biking, hiking, skiing, and fly-fishing,” says Blanchard.

The city raises funds to buy land within the watershed through a surcharge on water customers’ monthly bills, which provides around $1.5 million each year to protect watershed lands from development. Since 1907, the city has managed to purchase over 23,000 acres of the watershed.

“Despite the popularity and power of the Catskills narrative to promote the preservation of ecosystems via market-based incentives, we found that this narrative is at best partial, and quite possibly flawed,” says Blanchard.

“The Wasatch’s absence in the ecosystem literature results in an incomplete perspective on interventions to secure watershed ecosystem services and limits policy discussions in relation to alternative conservation approaches. It is vital that such alternatives are given more recognition in order to find effective solutions for the protection of natural capital in the future.”

Reference:

Blanchard, L et al. “The lost narrative: Ecosystem service narratives and the missing Wasatch watershed conservation story” Ecosystem Services, December 2015. The paper can be accessed at http://dx.doi.org/10.1016/j.ecoser.2015.10.019 

Libby Blanchard’s research is funded by the Gates Cambridge Trust.

Inset image: Recreation in the Wasatch watershed (Libby Blanchard).

Human-level intelligence is familiar in biological “hardware” – it happens inside our skulls. Technology and science are now converging on a possible future where similar intelligence can be created in computers.

While it is hard to predict when this will happen, some researchers suggest that human-level AI will be created within this century. Freed of biological constraints, such machines might become much more intelligent than humans. What would this mean for us? Stuart Russell, a world-leading AI researcher at the University of California, Berkeley, and collaborator on the project, suggests that this would be “the biggest event in human history”. Professor Stephen Hawking agrees, saying that “when it eventually does occur, it’s likely to be either the best or worst thing ever to happen to humanity, so there’s huge value in getting it right.”

Now, thanks to an unprecedented £10 million grant from the Leverhulme Trust, the University of Cambridge is to establish a new interdisciplinary research centre, the Leverhulme Centre for the Future of Intelligence, to explore the opportunities and challenges of this potentially epoch-making technological development, both short and long term.

The Centre brings together computer scientists, philosophers, social scientists and others to examine the technical, practical and philosophical questions artificial intelligence raises for humanity in the coming century.

Huw Price, the Bertrand Russell Professor of Philosophy at Cambridge and Director of the Centre, said: “Machine intelligence will be one of the defining themes of our century, and the challenges of ensuring that we make good use of its opportunities are ones we all face together. At present, however, we have barely begun to consider its ramifications, good or bad”.

The Centre is a response to the Leverhulme Trust’s call for “bold, disruptive thinking, capable of creating a step-change in our understanding”. The Trust awarded the grant to Cambridge for a proposal developed with the Executive Director of the University’s Centre for the Study of Existential Risk (CSER), Dr Seán Ó hÉigeartaigh. CSER investigates emerging risks to humanity’s future including climate change, disease, warfare and technological revolutions.

Dr Ó hÉigeartaigh said: “The Centre is intended to build on CSER’s pioneering work on the risks posed by high-level AI and place those concerns in a broader context, looking at themes such as different kinds of intelligence, responsible development of technology and issues surrounding autonomous weapons and drones.”

The Leverhulme Centre for the Future of Intelligence spans institutions, as well as disciplines. It is a collaboration led by the University of Cambridge with links to the Oxford Martin School at the University of Oxford, Imperial College London, and the University of California, Berkeley. It is supported by Cambridge’s Centre for Research in the Arts, Social Sciences and Humanities (CRASSH). As Professor Price put it, “a proposal this ambitious, combining some of the best minds across four universities and many disciplines, could not have been achieved without CRASSH’s vision and expertise.”

Zoubin Ghahramani, Deputy Director, Professor of Information Engineering and a Fellow of St John’s College, Cambridge, said:

“The field of machine learning continues to advance at a tremendous pace, and machines can now achieve near-human abilities at many cognitive tasks—from recognising images to translating between languages and driving cars. We need to understand where this is all leading, and ensure that research in machine intelligence continues to benefit humanity. The Leverhulme Centre for the Future of Intelligence will bring together researchers from a number of disciplines, from philosophers to social scientists, cognitive scientists and computer scientists, to help guide the future of this technology and  study its implications.”

The Centre aims to lead the global conversation about the opportunities and challenges to humanity that lie ahead in the future of AI. Professor Price said: “With far-sighted alumni such as Charles Babbage, Alan Turing, and Margaret Boden, Cambridge has an enviable record of leadership in this field, and I am delighted that it will be home to the new Leverhulme Centre.”

Following the statement of Prime Minister David Cameron to the House of Commons entitled: “Prime Minister’s Response to the Foreign Affairs Select Committee on the Extension of Offensive British Military Operations to Syria“, Dr Veronika Fikfak and Dr Hayley J Hooper discuss the questionable international legality of military action, the strategic use of parliament and its potential impact upon the emerging Consultation Convention, and the responsibility of MPs to hold government to account across a broad range of relevant domestic issues.

They analyse the impact of the way government shares intelligence information with the House of Commons, especially in light of the 2003 Iraq conflict, highlighting several relevant but under-discussed rules. Finally, they discuss the role of party political discipline on armed conflict votes.

Dr Fikfak researches in the fields of public law, human rights and international law. She is particularly interested in the interface between domestic and international law and is currently writing a monograph on the role of national judges in relation to international law. Dr Hooper is currently a Fellow at Homerton College, and her doctoral research at Balliol College, University of Oxford concerned the use of “closed” or “secret” evidence in the context of judicial review of counterterrorism powers, and its extension to civil procedure more broadly.

Drs Fikfak and Hooper are currently co-authoring a monograph on parliament’s involvement in war powers entitled Parliament’s Secret War (forthcoming with Hart Bloomsbury, 2016).

Law in Focus is a series of short videos featuring academics from the University of Cambridge Faculty of Law, addressing legal issues in current affairs and the news. These issues are examples of the many which challenge researchers and students studying undergraduate and postgraduate law at the Faculty. Law in Focus is available on YouTube, or to subscribe to in iTunes U.

Other collections of video and audio recordings from the Faculty of Law are available at Lectures at Law.

Research at the University of Cambridge to support the UK’s infrastructure and cities has received further backing in the form of two major funding initiatives. The Centre for Smart Infrastructure and Construction (CSIC) has secured a further five years of funding from the Engineering and Physical Sciences Research Council (EPSRC) and Innovate UK; while the UK Collaboratorium for Research in Infrastructure and Cities (UKCRIC), of which Cambridge is a partner, has secured £138 million of funding, to be match funded from other sources, as part of last week’s spending review.

The additional funding to CSIC will allow it to build on its significant achievements over the past five years to become a widely-recognised hub for the infrastructure and construction industry, bringing together leading academics and industrialists, developing a faster route for innovation adoption, providing an ecosystem for building confidence in new innovations and enabling their timely implementation and exploitation.

“CSIC will continue to engage with business leaders and decision makers in key markets to ensure that our work continues to meet industry needs, and that industry leaders are well informed of the value that ‘smart’ innovations in infrastructure and construction can bring to their business,” said Jennifer Schooling, Director of CSIC. “CSIC’s ability to deliver value is unrivalled. Our outputs present real opportunities to make major improvements in how we create new infrastructure.”

There has already been substantial impact of CSIC’s activities in terms of the wide variety of tools and technologies – including fibre optic strain measurement, UtterBerry ultra-low power wireless sensor motes, vibration energy harvesting devices and CSattAR photogrammetric monitoring system – recently deployed on some of the largest civil engineering projects including Crossrail, National Grid, London Underground, CERN and the Staffordshire Alliance.

The application of CSIC’s capability and knowledge is now being broadened to new markets including water infrastructure, highways and power.

“Securing this funding for the next five years offers a wide range of opportunities to take CSIC’s work forward and embed a culture of innovation adoption in the infrastructure and construction industries,” said Schooling. “CSIC cannot achieve this alone – working with industry is the key to our success to date and we always welcome approaches from industry partners seeking to collaborate.”

Professor Philip Nelson, CEO, EPSRC, said: “The Centre will continue its leading role within the UK by increasing the lifetime of ageing infrastructure, making it more resilient, and making construction processes more efficient by using smart sensing technology. This collaborative research between academia and industry will increase the UK’s competitiveness, lead to savings quantified in millions of pounds and provide technology that can be exported for UK based companies.”

Kevin Baughan, Director of Technology and Innovation at Innovate UK said: “The work of CSIC has helped to demonstrate the value of smart infrastructure to the construction industry, and this is reflected in the recognition of innovation at the heart of the future plans of the construction leadership council. By extending funding for a further five years, we underline our support for their commitment to raise the commercialisation bar even higher. This will help companies of all sizes grow through leveraging the excellent UK science base in smart infrastructure.”

UKCRIC is a collaboration of 14 UK universities which aims to provide a knowledge base to ensure the long-term functioning of the UK’s transport systems, energy systems, clean water supplies, waste management, flood defences and the development of SMART infrastructures.

Outside national security and medicine, UKCRIC will be one of the largest collaborative research projects in the UK. Current national and international partners include: Bristol City Council, Network Rail, Mott MacDonald, Buro Happold, Atkins, National Grid, DfT, EDF and Thames Water, with many more partners to follow. In order to tap further into the UK’s expertise and creativity UKCRIC’s founding core of 14 universities will be expanded over the coming years.

Cambridge will receive funding through UKCRIC which will be used to support research in the application of advanced sensor technologies to the monitoring of the UK’s existing and future infrastructure, in order to protect and maintain it.

UKCRIC programmes will integrate research on infrastructure needs, utilisation and performance through experiments, analysis, living labs and modelling. This will provide a new combination of decision support tools to inform infrastructure operators, planners, financiers, regulators, cities, and government on the optimisation of infrastructure capacity, performance and investment.

The results, published in the journalScience, are based on new radio observations tracking a star as it gets torn apart by a black hole. Such violent events yield a burst of light which is produced as the bits and pieces of the star fall into the black hole. For the first time, the researchers were able to show that this burst of light is followed by a radio signal from the matter that was able to escape the black hole by travelling away in a jetted outflow at nearly the speed of light.

The discovery of the jet was made possible by a rapid observational response after the stellar disruption (known as ASAS-SN-14li) was announced in December 2014. The radio data was taken by the by the 4 PI SKY team at Oxford, using the Arcminute Microkelvin Imager Large Array located in Cambridge.

“Previous efforts to find evidence for these jets, including my own, were late to the game,” said Sjoert van Velzen of Johns Hopkins University, the study’s lead author. Co-author Nicholas Stone added that “even after they got to the game, these earlier attempts were observing from the bleachers, while we were the first to get front row seats.”

In this branch of astronomy, the ‘front row’ means a distance of 300 million light years, while previous observations were based on events at occurring least three times as far away.

Jets are often observed in association with black holes, but their launch mechanism remains a major unsolved problem in astrophysics. Most supermassive black hole are fed a steady diet of gas, leading to jets that live for millions of years and change little on a human timescale. However, the newly discovered jet behaved very differently: the observations show that following a brief injection of energy, it produced short but spectacular radio fireworks.

The observed jet was anticipated by the so-called scale-invariant model of accretion, also known as the Matryoshka-doll theory of astrophysics. It predicts that all compact astrophysical objects (white dwarfs, neutron stars, or black holes) that accrete matter behave and look the same after a simple correction based on solely the mass of the object. In other words, the larger Matryoshka doll (a supermassive black hole) is just a scaled-up version of the smaller doll (a neutron star). Since neutron stars consistently produce radio-emitting jets when they are supplied with a large amount of gas, the theory predicts that supermassive black holes should do the same when they swallow a star.

“I always liked the elegant nature of the scale-invariant theory, but previous observations never found evidence for the new type of jet it predicted,” said van Velzen. “Our new findings suggest that this new type of jet could indeed be common and previous observations were simply not sensitive enough to detect them.”

“These jets are a unique tool for probing supermassive black holes,” said co-author Dr Morgan Fraser of Cambridge’s Institute of Astronomy. “While black holes themselves do not emit light, by observing how a star is torn apart as it falls in we can indirectly study the sleeping monster at the heart of a galaxy.”

The study hypothesises that every stellar disruption leads to a radio flare similar to the one just discovered. Ongoing surveys such as the Gaia Alerts project, led by the University of Cambridge will find many more of these rare events.

“Gaia has exceptionally sharp eyes, and is ideally suited to find events like this, which occur in the very centres of galaxies,” said co-author Dr Heather Campbell, also from Cambridge’s Institute of Astronomy. “Finding more of these rare events may further our understanding of the processes that allow black holes to launch such spectacular outflows.”

Reference:
Van Velzen, S. et. al. ‘A radio jet from the optical and X-ray bright stellar tidal disruption flare ASASSN-14li.’ Science (2015). DOI: 10.1126/science.aad1182

Adapted from a Johns Hopkins press release. 

Health services in many countries increasingly rely on prescribed ‘psychosocial interventions’: treatments that use counselling techniques to tackle mental health issues, behavioural problems such as substance abuse, and assist parents with new or troubled children.

These highly-regarded therapeutic and educational programmes, devised by senior academics and practitioners, are sold commercially to public health services across the world on the basis that they are effective interventions for people in need of support – with the evidence to back them up.

However, the first study to investigate conflicts of interest in the published evidence for intervention treatments has revealed that the majority of academic studies which assert evidence of effectiveness list authors who profit from the distribution of these programmes, yet few declare a conflict of interest.

In fact, the new research shows that as many as two-thirds of the studies that list an author who financially benefits from sales of said treatment programmes declare no conflict of interest whatsoever.

While major steps have been taken to counter research bias in other fields such as pharmaceuticals, the new study’s authors say that hugely influential psychosocial treatments suffer a distinct lack of transparency from academics that both publish research on treatment effectiveness and stand to gain significantly from any positive findings.

They write that as commercial psychosocial treatments – many of which cost hundreds, even thousands, of dollars per participant – continue to gain traction with national public health services, it is important that “systems for effective transparency are implemented” to ensure clinical commissioning bodies are aware of potential research biases. The findings are published today in the journal PLOS ONE.

“Contrary to some, I have no problem with introducing commercial programmes into a national health service if decision makers and trusts come to the conclusion that a commercially disseminated treatment is more effective than their current psychosocial offerings, but this must be based on fair and transparent evidence,” said the study’s lead author Professor Manuel Eisner, from Cambridge’s Institute of Criminology.

“What you don’t want to see is an intervention system that remains as effective, or becomes less effective, despite buying in expensive programmes, because you have a public goods service competing with research that has a commercial interest to publish overly optimistic findings,” Eisner said.

“Policy makers in public health have a right to expect transparency about conflicts of interest in academic research.”

Four internationally disseminated psychosocial interventions – described by Eisner as “market leaders” – were examined: the Positive Parenting Programme (or Triple P); theNurse-Family Partnership; the parenting and social skills programme Incredible Years; the Multi-Systemic Therapy intervention for youth offenders.

The researchers inspected all articles published in academic journals between 2008 and 2014 on these interventions that were co-authored by at least one lead developer of the programme – a total of 136 studies.

Two journal editors refused consent to be included in the research, leaving 134 studies. Of all these studies, researchers found 92 of them – equalling 71% – to have absent, incomplete or partly misleading conflict of interest disclosures.

The research team contacted journal editors about the 92 published studies on the effectiveness of one of these four commercial psychosocial interventions co-authored by a primary developer of the self-same therapy, yet listed no conflict of interest, or, in the case of a few, an incomplete one.

This led to 65 of the studies being amended with an ‘erratum’, or correction. In 16 cases, the journal editors admitted “mishandling” a disclosure, resulting in the lack of a conflict of interest statement.

In the remaining 49 cases, the journal editors contacted the study’s authors seeking clarification. In every case the authors submitted a new or revised conflict of interest. Eisner and colleagues write that the “substantial variability in disclosure rates suggests that much responsibility seems to lie with the authors”.

The most common reason given by those journals that did not issue a correction was that they did not have a conflict of interest policy in place at the time of the published study’s submission.

While the overall rate of adequate disclosures in clear cases of conflict of interest was less than a third, just 32%, the rates for the four programmes varied significantly. The lowest rate of disclosures was found in academic studies on the Triple P programme, at just 11%.

Triple P is a standardised system of parenting support interventions based on cognitive-behavioural therapy. Initially developed by Professor Matthew Sanders at the University of Queensland, Triple P has sold around seven million copies of its standard programme across 25 countries since it began commercial operations in 1996, with over 62,000 licensed providers – mainly trained psychologists.

In 2001, Queensland ‘spun out’ the licencing contract into a private company, the royalties from which are distributed between three groups of beneficiaries: Queensland University itself, Prof Sanders’ Parenting and Family Support Centre (also at Queensland), and the authors of Triple P.

Despite being one of the most widely evaluated parenting programmes worldwide, the evidence for the success of Triple P is controversial, say the researchers.

Several analyses of Triple P – including those by Triple P authors with previously undeclared conflicts of interest – show positive effects. However, at least one independent systematic review cited in the new PLOS ONE study found “no convincing evidence” that the Triple P has any positive effects in the long run.

“Researchers with a conflict of interest should not be presumed to conduct less valid scholarship, and transparency doesn’t necessarily improve the quality of research, but it does make a difference to how those findings are assessed,” said Eisner.

In the Journal of Child and Family Studies in January 2015, Triple P creator Prof Sanders wrote that “[p]artly as a result of these types of criticisms” his research group had “undertaken a comprehensive review of our own quality assurance practices”.

Added Eisner: “The development of standardised, evidence-based programmes such as Triple P is absolutely the right thing to do. If we have comparable interventions providing an evidence base then it promotes innovation and stops us running around in circles. But we need to be able to trust the findings, and that requires transparency when it comes to conflicts of interest.”

Enzymes are biological catalysts – molecules that speed up chemical reactions within living materials. Many enzymes are already well characterised and their functions fairly well understood. For example, the enzyme known as MMP8 is present in the connective tissue of most mammals, where it breaks the chemical bonds found in collagen.

In pre-clinical research published in the journal Chemistry & Biology, Dr Florian Hollfelder from the Department of Biochemistry at Cambridge and Dr Lutz Jermutus,Senior Director, Research and Development at MedImmune, led a study to map a list of human enzymes (proteases) against potential protein drug targets.

Using automation technology at MedImmune, the team then tested each of the enzymes against each target protein in turn, allowing them to identify a significant number of so-far unknown interactions.

Of particular interest was how MMP8 was able to disable a molecule known as IL-13, which is known to play an important role in several inflammatory diseases such as asthma and dermatitis. The researchers believe this may be a previously-unknown way in which the body regulates the action of IL-13, preventing these diseases in the majority of individuals. If so, it could provide an interesting target for new drugs against these common diseases.

“MMP8 is well-known to biochemists and we all thought we understood its function, but it’s clear that this – and probably many other enzymes – ‘moonlight’ and have several functions within the body,” explains Dr Hollfelder. “Because the enzyme already had a ‘name’ and a function, nobody thought to see if it had a promiscuous side.”

Designing new enzymes has proven an extremely difficult technical challenge, hence the drive to find new uses for previously ‘understood’ enzymes. By focusing on human proteases, rather than bacterial proteases – which are actually easier to source – the researchers are confident that their research will be far more applicable to drug discovery.

“Our approach is new: we ‘recycle’ known enzymes and ask whether they can do other things than the ones they are known for,” adds Dr Jermutus. “In fact, we believe we have found other enzymes that could be similarly deployed against other disease-causing proteins, and this approach, if expanded, could provide further leads for new drugs.”

Commenting on the benefits of the collaboration with industry, Dr Hollfelder adds: “Without MedImmune, our work would have stopped after seeing and characterising the interactions. The additional extension to cell and mouse models would have been inconceivable in my basic science group.”

Reference
Urbach, C et al. Combinatorial Screening Identifies Novel Promiscuous Matrix Metalloproteinase Activities that Lead to Inhibition of the Therapeutic Target IL-13. Chemistry & Biology; 19 Nov 2015

Most of the fat cells in the body act to store excess energy and release it when needed but some types of fat cells, known as brown adipocytes, function primarily for a process known as thermogenesis, which generates heat to keep us warm. However, an international team of researchers from the Wellcome Trust-Medical Research Council Institute of Metabolic Sciences at the University of Cambridge, UK, and Toho University, Japan, have shown that a protein found in the body, known as sLR11, acts to suppress this process.

Researchers investigated why mice that lacked the gene for the production of this protein were far more resistant to weight gain. All mice – and, in fact, humans – increase their metabolic rate slightly when switched from a lower calorie diet to a higher calorie diet, but mice lacking the gene responded with a much greater increase, meaning that they were able to burn calories faster.

Further examinations revealed that in these mice, genes normally associated with brown adipose tissue were more active in white adipose tissue (which normally stores fat for energy release). In line with this observation, the mice themselves were indeed more thermogenic and had increased energy expenditure, particularly following high fat diet feeding.

The researchers were able to show that sLR11 binds to specific receptors on fat cells – in the same way that a key fits into a lock – to inhibit their ability to activate thermogenesis. In effect, sLR11 acts as a signal to increase the efficiency of fat to store energy and prevents excessive energy loss through unrestricted thermogenesis.

When the researchers examined levels of sLR11 in humans, they found that levels of the protein circulating in the blood correlated with total fat mass – in other words, the greater the levels of the protein, the higher the total fat mass. In addition, when obese patients underwent bariatric surgery, their degree of postoperative weight loss was directly proportional to the reduction in their sLR11 levels, suggesting that sLR11 is produced by fat cells.

In their paper the authors suggest that sLR11 helps fat cells resist burning too much fat during ‘spikes’ in other metabolic signals following large meals or short term drops in temperature. This in turn makes adipose tissue more effective at storing energy over long periods of time.

There is growing interest in targeting thermogenesis with drugs in order to treat obesity, diabetes and other associated conditions such as heart disease. This is because it offers a mechanism for disposing of excess fat in a relatively safe manner. A number of molecules have already been identified that can increase thermogenesis and/or the number of fat cells capable of thermogenesis. However to date there have been very few molecules identified that can decrease thermogenesis.

These findings shed light on one of the mechanisms that the body employs to hold onto stored energy, where sLR11 levels increase in line with the amount of stored fat and act to prevent it being ‘wasted’ for thermogenesis.

Dr Andrew Whittle, joint first author, said: “Our discovery may help explain why overweight individuals find it incredibly hard to lose weight. Their stored fat is actively fighting against their efforts to burn it off at the molecular level.”

Professor Toni Vidal-Puig, who led the team, added: “We have found an important mechanism that could be targeted not just to help increase people’s ability to burn fat, but also help people with conditions where saving energy is important such as anorexia nervosa.”

Jeremy Pearson, Associate Medical Director at the British Heart Foundation (BHF), which helped fund the research, said: “This research could stimulate the development of new drugs that either help reduce obesity, by blocking the action of this protein, or control weight loss by mimicking its action. Based on this promising discovery, we look forward to the Cambridge team’s future findings.

“But an effective medicine to treat obesity, which safely manages weight loss is still some way off. In the meantime people can find advice on healthy ways to lose weight and boost their heart healthy on the BHF website.”

The study was part-funded in part by the British Heart Foundation, the Wellcome Trust, the Medical Research Council and the Biotechnology and Biological Sciences Research Council.

Reference
Whittle, AJ, Jiang, M, et al. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nature Communications; 20 November 2015

Do the ethics of a person’s negotiating tactics differ when they negotiate with someone from a different country? A new study co-authored at University of Cambridge Judge Business School suggests that they do.

While some prior studies have looked at the relative negotiating ethics of different nationalities, the new study, entitled “How ethically would Americans and Chinese negotiate? The effect of intra-cultural versus inter-cultural negotiations”, published in the Journal of Business Ethics looks at a significant new factor: it finds that the nationality of the counterparty to negotiations can make people prefer the use of more or less ethical strategies, particularly in areas such as false promises and inappropriate information gathering.

“Business is increasingly global, so ethical concerns are becoming more important in terms of cross-national business and negotiations,” said co-author David De Cremer, KPMG Professor of Management Studies at Cambridge Judge. “This study shows that the other party’s nationality can affect the ethics of negotiating tactics, and this has important implications.”

The study is co-authored by Yu Yang of ShanghaiTech University, David De Cremer of Cambridge Judge Business School, and Chao Wang of the University of Illinois.

The study looks specifically at negotiations between Americans and Chinese, and doesn’t compile data involving other nationalities – but it suggests that the findings are not restricted to negotiations between US and Chinese nationals.

“Our current analysis suggests that people may change their use of ethically questionable tactics when they negotiate with someone from a different country,” the study says. “In negotiations, people adopt different models of what is ethically acceptable for themselves in intra-cultural versus inter-cultural situations.”

Specifically, the study found that American participants were more likely to use “ethically questionable” tactics in negotiations with Chinese (particularly related to dubious information gathering and false promises) than in negotiations with fellow Americans; for their part, Chinese participants were less likely to use ethically questionable tactics in negotiations with Americans (particularly related to false promises and “attacking the opponent’s network,” such as attempting to get the counterparty fired so a new person will take their place) than in intra-cultural negotiations with other Chinese.

“The US and China are currently the two largest economies in the world,” the study says. “Given the importance and complexity of this bilateral relationship, we must address how negotiations in such circumstances are shaped, particularly with respect to the norms and ethics being used when the representatives of both countries approach each other.”

The study is based on 389 American and 421 Chinese participants, all over age 22, with the vast majority employed and with at least some college education.

Participants were outlined a scenario: “You are the lead negotiator for a company that manufactures heavy equipment,” and are about to negotiate a deal to sell expensive excavators; the market is very competitive and your company has not met recent targets, and “if this sale is not secured your company will incur a loss.”

Each person works for a company located either in the US state of Illinois or in Hunan, China; the only variable is the counterparty (and their presumed nationality), who is located either “nearby” in your own country or “far away” (in the US or China), named either “Justin Adams” or “Jia Liu.”

Participants were asked, on a scale of one to seven, their likelihood of using 16 “ethically questionable” (in various degrees) negotiation strategies. In five broad categories, these strategies comprise false promises, misrepresentation to strengthen negotiating position, inappropriate information gathering about the counterparty’s negotiating position, attacking the opponent’s network, and “traditional” competitive bargaining such as inflated opening demands.

The study then calculated participants’ likelihood of overall use of ethically questionable negotiation tactics, as well as a breakdown by category.

“American participants were significantly more likely to use ethically questionable negotiation tactics in inter-cultural negotiations (Mean 3.00) with Chinese counterparts than in intra-cultural negotiations (Mean 2.75) with American counterparts. By contrast, Chinese participants were marginally less likely to use such tactics in inter-cultural negotiations (Mean 3.92) with American counterparts than in intra-cultural negotiations (Mean 4.06) with Chinese counterparts.”

The study concludes: “As current business relationships are increasingly built on a global level, ethical concerns will become an even more important issue in future cross-national business negotiations. As such, we strongly believe that a more nuanced understanding of ethical practices in different countries needs to be developed.”

Reference:
Yu Yang et. al. ‘How ethically would Americans and Chinese negotiate? The effect of intra-cultural versus inter-cultural negotiations‘. Journal of Business Ethics (2015). DOI: 10.1007/s10551-015-2863-2

Originally published on the Cambridge Judge Business School website. 

Are there actually Martians out there? Could life survive in boiling water? And more importantly, what is your dog really thinking?

If these are the sort of questions that keep you awake at night, then help is finally at hand, in the form of a new website created by a team of scientists at Cambridge and featuring contributions from a host of leading academics.

Named Forty Two (after Douglas Adams’ famously cryptic solution to the meaning of life), the site is an online resource dedicated to the subject of evolution, and includes video interviews in which researchers including Sir David Attenborough, Simon Conway Morris, Eugene Koonin, and Carenza Lewis offer their views on topics ranging from the nature of evolution itself, to the future of life as we know it.

Aimed at general readers and, in particular, young people who are just starting to get into science, its aim is to provide an innovative and authoritative source of information about evolution on the web.

Its creators also hope to demonstrate that evolution is a subject that is, in itself, evolving. To prove this, the site uses the study of evolution to attempt to answer a host of knotty problems drawn from the fringes of current scientific understanding – questions such as “Can you have blue blood?”, “Do insects copulate with flowers?” and “Can you see heat?”

The site was created by a team led by Simon Conway Morris, Professor of Evolutionary Palaeobiology and a Fellow of St John’s College at the University of Cambridge. “Evolution is true, and if it didn’t happen, we wouldn’t be here,” he said. “Like all the sciences, evolution is constantly, well, evolving. New insights and unexpected discoveries combine with seeing old things in a completely new light. It is active, dynamic, changing and unpredictable. We wanted to create a website that captures the excitement and thrill of that exploration.”

The site features a unique video archive that collects the thoughts of leading scientists around the world. The most familiar, Sir David Attenborough, is, for example, captured reflecting with troubling pessimism about the future of the planet, in response to the question: “Are you optimistic about the human species?” “The truthful answer is that I am not,” he replies. “It seems to me almost inevitable that things are going to get worse before they get better… and the only way that we can stop that is by reducing carbon emissions very, very quickly indeed.”

Around that archive, the website’s designers have constructed a living database of information about evolutionary studies that illustrates the scope and scale of the scientific discussion that Darwin brought to the fore of public debate more than 150 years ago.

Dr Victoria Ling, from the University’s Department of Earth Sciences, said: “When you type ‘evolution’ into Google you get a lot of information, not all of which is very reliable, but even the sources that are reliable can inadvertently give the impression that evolution was ‘solved’ with Darwin. In fact, evolution remains a vibrant area of research and there’s an awful lot left to learn. We wanted to produce a site which showcases that ongoing discussion, one which has plenty of serious content, but also a strong sense of fun.”

The core material is divided into three main subject areas: “Here And Now”, for topics on which the scientific community has reached a rough consensus; “Near Horizons”, for nagging questions that are hotly debated; and “Far Horizons”, for really big issues that sit at the edge of current knowledge.

Users can also play a careers game that takes a light-hearted look at some of the real tasks real scientists can end up doing in the course of their work. This is personalised to the user’s interests based upon their answers to the questions “What am I into?” “How does my mind work?” and “Where is my focus?”. Historians can meanwhile delve into a selection of potted biographies of scientific pioneers, ranging from familiar figures such as Darwin himself, to lesser-sung heroes and heroines, such as the 19th-century fossil collector Mary Anning, and the American cytogeneticist Barbara McClintock.

Perhaps, however, the site’s most revelatory feature is its selection of Q&A topics so bizarre that they periodically sound more like something out of science fiction, as Douglas Adams himself might have hoped.

Who knew, for example, that rattlesnakes really can “see” heat, in a manner of speaking, thanks to evolved pits close to the front of their faces that relay information about thermal contrasts to the same part of the brain that registers information from the eyes? Or that dogs, which have evolved alertness to human gestures but appear to lack self-awareness may simply be part of a greater consciousness that we ourselves have yet to fathom?

As for the Martians, the answer remains similarly unclear, but Conway-Morris suggests that we might be looking at the wrong planet for alien life. One theory has it that Venus could technically be inhabited by aerial microbes – something equivalent to the extremophiles found on Earth – ekeing out their existence amid the sulphuric clouds shrouding the planet.

“Even today maybe Venusian aerial life wafts its way across the 25 million miles or so of space that separate us,” Conway Morris writes. “Unlikely? Most certainly. Impossible? Perhaps not.”

For more, visit: http://www.42evolution.org/

Additional images taken from www.42evolution.org. 

The first sequencing of ancient genomes extracted from human remains that date back to the Late Upper Palaeolithic period over 13,000 years ago has revealed a previously unknown “fourth strand” of ancient European ancestry.

This new lineage stems from populations of hunter-gatherers that split from western hunter-gatherers shortly after the ‘out of Africa’ expansion some 45,000 years ago and went on to settle in the Caucasus region, where southern Russia meets Georgia today.

Here these hunter-gatherers largely remained for millennia, becoming increasingly isolated as the Ice Age culminated in the last ‘Glacial Maximum’ some 25,000 years ago, which they weathered in the relative shelter of the Caucasus mountains until eventual thawing allowed movement and brought them into contact with other populations, likely from further east.

This led to a genetic mixture that resulted in the Yamnaya culture: horse-borne Steppe herders that swept into Western Europe around 5,000 years ago, arguably heralding the start of the Bronze Age and bringing with them metallurgy and animal herding skills, along with the Caucasus hunter-gatherer strand of ancestral DNA – now present in almost all populations from the European continent.

The research was conducted by an international team led by scientists from Cambridge University, Trinity College Dublin and University College Dublin. The findings are published today in the journal Nature Communications.

“The question of where the Yamnaya come from has been something of a mystery up to now,” said one of the lead senior authors Dr Andrea Manica, from Cambridge’s Department of Zoology.

“We can now answer that as we’ve found that their genetic make-up is a mix of Eastern European hunter-gatherers and a population from this pocket of Caucasus hunter-gatherers who weathered much of the last Ice Age in apparent isolation. This Caucasus pocket is the fourth major strand of ancient European ancestry, one that we were unaware of until now,” he said

Professor Daniel Bradley, leader of the Trinity team, said: “This is a major new piece in the human ancestry jigsaw, the influence of which is now present within almost all populations from the European continent and many beyond.”

Previously, ancient Eurasian genomes had revealed three ancestral populations that contributed to contemporary Europeans in varying degrees, says Manica.

Following the ‘out of Africa’ expansion, some hunter-gatherer populations migrated north-west, eventually colonising much of Europe from Spain to Hungary, while other populations settled around the eastern Mediterranean and Levant, where they would develop agriculture around 10,000 years ago. These early farmers then expanded into and colonised Europe.

Lastly, at the start of the Bronze Age around 5,000 years ago, there was a wave of migration from central Eurasia into Western Europe – the Yamnaya.

However, the sequencing of ancient DNA recovered from two separate burials in Western Georgia – one over 13,000 years old, the other almost 10,000 years old – has enabled scientists to reveal that the Yamnaya owed half their ancestry to previously unknown and genetically distinct hunter-gatherer sources: the fourth strand.

By reading the DNA, the researchers were able to show that the lineage of this fourth Caucasus hunter-gatherer strand diverged from the western hunter-gatherers just after the expansion of anatomically modern humans into Europe from Africa.

The Caucasus hunter-gatherer genome showed a continued mixture with the ancestors of the early farmers in the Levant area, which Manica says makes sense given the relative proximity. This ends, however, around 25,000 years ago – just before the time of the last glacial maximum, or peak Ice Age.

At this point, Caucasus hunter-gatherer populations shrink as the genes homogenise, a sign of breeding between those with increasingly similar DNA. This doesn’t change for thousands of years as these populations remain in apparent isolation in the shelter of the mountains – possibly cut off from other major ancestral populations for as long as 15,000 years – until migrations began again as the Glacial Maximum recedes, and the Yamnaya culture ultimately emerges. 

“We knew that the Yamnaya had this big genetic component that we couldn’t place, and we can now see it was this ancient lineage hiding in the Caucasus during the last Ice Age,” said Manica.

While the Caucasus hunter-gatherer ancestry would eventually be carried west by the Yamnaya, the researchers found it also had a significant influence further east. A similar population must have migrated into South Asia at some point, says Eppie Jones, a PhD student from Trinity College who is the first author of the paper.

“India is a complete mix of Asian and European genetic components. The Caucasus hunter-gatherer ancestry is the best match we’ve found for the European genetic component found right across modern Indian populations,” Jones said. Researchers say this strand of ancestry may have flowed into the region with the bringers of Indo-Aryan languages.

The widespread nature of the Caucasus hunter-gatherer ancestry following its long isolation makes sense geographically, says Professor Ron Pinhasi, a lead senior author from University College Dublin. “The Caucasus region sits almost at a crossroads of the Eurasian landmass, with arguably the most sensible migration routes both west and east in the vicinity.”

He added: “The sequencing of genomes from this key region will have a major impact on the fields of palaeogeneomics and human evolution in Eurasia, as it bridges a major geographic gap in our knowledge.”

David Lordkipanidze, Director of the Georgian National Museum and co-author of the paper, said: “This is the first sequence from Georgia – I am sure soon we will get more palaeogenetic information from our rich collections of fossils.”

Inset image: the view from the Satsurblia cave in Western Georgia, where a human right temporal bone dating from over 13,000 years ago was discovered. DNA extracted from this bone was used in the new research.

Reference:
E.R. Jones et. al. ‘Upper Palaeolithic genomes reveal deep roots of modern Eurasians.’ Nature Communications (2015). DOI: 10.1038/ncomms9912

The report, “Unhedgeable Risk: How climate change sentiment impacts investment,” concluded that about half of this potential loss could be avoided through portfolio reallocation, while the other half is “unhedgeable”, meaning that investors cannot necessarily protect themselves from losses unless action on climate change is taken at a system level.

“This new research indicates that no investor is immune from the risks posed by climate change, even in the short run,” said Jake Reynolds, Director, Sustainable Economy at the Cambridge Institute for Sustainability Leadership. “However, it is surprisingly difficult to distinguish between risks that can be addressed by an individual investor through smart hedging strategies, and ones that are systemic and require much deeper transformations in the economy to deal with. That’s what this report attempts to do.”

While existing studies have analysed the direct, physical effects of climate change on long-term economic performance, this new report, commissioned by CISL and the Investment Leaders Group, looks at the short-term risks stemming from how investors react to climate-related information, from policy decisions and technology uptake, to market confidence and weather events.

Reynolds continued, “What’s new about this study is its focus on the potential short-term impacts which could surface at any time. Major events, such as the outcome of the upcoming United Nations climate talks in Paris in December, can send signals which drive market sentiment – sometimes slowly, sometimes rapidly – and this study allows us to model the implications.”

The study modelled the impact of three sentiment scenarios on four typical investment portfolios.

The scenarios tested were:

1. Two Degrees, limiting average temperature increase to two degrees Celsius (as recommended by the Intergovernmental Panel on Climate Change [IPCC]) and collectively making relatively good progress towards sustainability, and future socio-economic development goals.

2. Baseline, where past trends continue (i.e. the business-as-usual BAU scenario) and where there is no significant change in the willingness of governments to step up actions on climate change.

3. No Mitigation, oriented towards economic growth without any special consideration of environmental challenges, rather the hope that pursuing self-interest will allow adaptive responses to any climate change impacts as they arise.

The portfolio structures modelled were:

1. High Fixed Income, comprising 84 per cent fixed income, 12 per cent equity, four per cent cash; mimicking the strategies of insurance companies.

2. Conservative, comprising 60 per cent sovereign and corporate bonds, 40 per cent equity; mimicking certain pension funds.

3. Balanced, comprising 50 per cent equity, 47 per cent fixed income, three per cent commodities; mimicking certain pension funds.

4. Aggressive, comprising 60 per cent equity, 35 per cent fixed income, five per cent commodities; mimicking certain pension funds.

Each scenario was linked to a series of economic and market confidence factors used to explore macroeconomic effects within a global economic model. In turn these were cascaded down to portfolio level through an industry sector analysis. The factors included alternative levels of carbon taxation, fossil energy investment, green investment, energy and food prices, energy demand, market confidence, and housing prices.

The study found that shifts in climate change sentiment could cause global economic growth to reduce over a 5-10 year period in both the Two Degree and No Mitigation scenarios as a consequence of economic adjustment. In the longer-term, however, the study found that economic growth picks up most quickly along a Two Degrees (low carbon) pathway, with annual growth rates of 3.5 per cent not only exceeding the baseline (2.9 per cent), but significantly exceeding the No Mitigation scenario (2.0 per cent).

This is consistent with recent comments by the Governor of the Bank of England about the risk of “potentially huge” losses to financial markets due to climate change in the short term, and the “merit” of stress testing elements of the financial system to understand and deal with climate risks.

Urban Angehrn, Chief Investment Officer of Zurich Insurance Group and member of the Investment Leaders Group, echoed this view: “As an insurer we understand that the potential human impact and economic cost of extreme weather and climate events are vast. Multiplied by population growth, coastal migration and urbanisation, the threat seems even larger. We see it as our responsibility to help our customers and communities to build resilience against such events. As investors, the tools to help us translate that threat into investment decisions are – at present – limited. This report provides us with a meaningful basis to discuss investment strategies that tackle climate risk. It will help us go beyond the significant commitments that Zurich has already made.”

Under the Two Degrees scenario, the Aggressive portfolio suffers the largest loss in the short term, but it recovers relatively quickly and generates returns above and beyond the baseline projection levels by the end of the modelling period. In contrast, under a No Mitigation scenario, a

Conservative portfolio with a 40 per cent weighting to equities (typical of a pension fund) could suffer permanent losses of more than 25 per cent within five years after the shock is experienced.

“Far from being a lost cause, investors can ‘climate proof’ their investments to a significant extent by understanding how climate change sentiment could filter through to returns,” said Scott Kelly, research associate at the Centre for Risk Studies, University of Cambridge Judge Business School, and one of the authors of the report. “However, almost half the risk is “unhedgeable” in the sense that it cannot be addressed by individual investors. System-wide action is necessary to deal with this in the long-term interests of savers.”

The report offers a series of insights for investors, regulators and policy makers including:

• Seeing climate change as a short-term financial risk as well as a long-term economic threat.
• Recognising the value of “stress testing” investment portfolios for a wide range of sustainability risks (not only climate risks) to understand their financial impacts, and how to manage them.
• Pinpointing areas of “unhedgeable” risk where system-wide action is required to address risks that cannot be escaped by individual investors.
• The importance of using capital flows to improve the resilience and carbon profile of the asset base, especially in emerging markets.
• Identifying significant gaps in knowledge where new research is required, including of an interdisciplinary nature.

Originally published on the CISL website.

Good things come to those who wait – according to a marketing slogan for Heinz ketchup from the 1980s. But why is the ketchup so difficult to get out of the bottle? The reason is that ketchup is in two minds: whether to pour like a liquid or stay put like a solid. It is one example of soft matter – a huge class of materials which behave in complex and nonlinear ways.

We interact with soft matter every day: toothpaste, chocolate, shampoo and mayonnaise are all examples, which can behave either as liquids or solids depending on the circumstances. Soft matter can also be found in laptop screens, advanced batteries, and in the processing of functional ceramics and plastic LEDs. Cambridge researchers have developed new mathematical models to describe why these materials behave the way they do, which could help improve them for both domestic and high-tech applications.

Soft matter is the focus of the inaugural lecture by Professor Michael Cates, who was elected as the University of Cambridge’s 19^th Lucasian Professor of Mathematics earlier this year. His lecture, which will be held on Wednesday 4 November, will cover how mathematical models can explain how soft materials can suddenly convert from liquid-like to solid-like behaviour, through a process resembling an internal traffic jam.

Cates’ research aims to understand better why these materials behave as they do, allowing improved control for a range of future applications, including the design of entirely new materials with tailored properties.

In his lecture, Cates will discuss the ‘jamming’ behaviour of colloids and dense suspensions. Both are types of soft matter with an internal structure something like tiny ping-pong balls dispersed in a liquid. Recently, researchers have created ‘active’ colloids in which the ping-pong balls are self-propelled, like tiny rockets. When their propulsion is switched on, these particles form tight clusters, despite the fact that there are no attractive forces between them.

“The question in this case is what causes the clustering? More generally, how does the internal structure of various types of soft matter affect the way they behave?” said Cates. After considering other explanations – including the idea that the clusters arise by a process like the flocking of birds – Cates concluded that each cluster is effectively a sort of traffic jam.

As every driver knows, a smooth distribution of moving cars becomes unstable at high density, leading to the formation of traffic jams. These can be triggered by even a single driver lightly tapping the brakes, and the new mathematical model explains the spontaneous ‘clumping’ of active colloids in very similar terms.

“Having now understood what’s going on in these active systems, we hope to design better versions that can be used to create a wide range of new materials,” Cates said.

Cates and his colleagues have also looked at very dense suspensions, such as paints, molten chocolate or wet sand. Previous mathematical models have assumed that the particles in a dense suspension are hard and smooth, like ball bearings.

“The approximation of hard, smooth particles – though it has served us well for 25 years – does not predict the observed behaviour in these cases,” said Cates. “So we needed to figure out what physics was missing. And we’ve found the answer: a better description of friction between the particles.”

When a dense suspension flows in response to stress, the particles have to push past each other. So long as the stress is low, they easily slide past, with little friction between them. But when stress is increased, friction between the particles also increases. This smooth change in friction can trigger another jamming transition: the suspension suddenly gets much thicker when pushed too hard.

“In many dense suspensions, the aim is to maximise the amount of solids they contain without losing the ability to flow,” said Cates. “In paints, for example, this reduces both drying time and solvent vapour emissions. Now that we know how much friction matters, we can think of new ways to improve flow by reducing friction, so that we can pack more particles in. Allowing the particles to glide past each other by reducing friction is like solving the age-old problem of getting the ketchup out of the glass bottle.”

The Lucasian Professorship has an exceptionally long and distinguished history, established in 1663. Previous holders include Isaac Newton (1669-1702), and, more recently, Paul Dirac (1932-1969), James Lighthill (1969-1979), Stephen Hawking (1979-2009) and Michael Green (2009-2013).

Professor Cates’ lecture will take place at 5pm on Wednesday 4 November at the Department of Applied Mathematics and Theoretical Physics.