All posts by Adam Brinded

Time to ‘rewild’ the school system, argues Cambridge expert

Girl takes exam in a London secondary school.
Girl takes exam in a London secondary school.
Credit: Caia images/Getty

A new book warns that the school system may be “broken beyond repair”, claiming that it is deepening inequality and making children ill.

We are crying out for systemic transformation: a completely new vision of what education involves, however challenging that may beHilary Cremin

In Rewilding Education, Professor Hilary Cremin argues that modern schooling is defined by an obsession with standardisation and outdated thinking, while it fails to nurture creativity, critical thought, or the physical and mental health of students and teachers.

Cremin, who is Head of the Faculty of Education at the University of Cambridge, draws on decades of experience as a teacher, academic and consultant – as well as the work of other scholars – to put forward a programme for “long-term, radical change”, including a stronger focus on students’ social and emotional development alongside academic achievement.

The book’s numerous proposals include more lessons outdoors, and more projects that connect students to their communities beyond the school gates. Steps such as these, she argues, would help prepare young people to live responsibly – and well – in a rapidly changing world.

Cremin acknowledges that these ideas may be disparaged by traditionalists and policy-makers – as, indeed, they have been before. In 2013, she was one of 100 academic critics of Michael Gove’s educational reforms whom the then Education Secretary branded “enemies of promise”.

More than a decade later, she argues, there is still no evidence that those reforms, like many before and since, have narrowed the attainment gap between wealthy and poorer students as promised. Research shows that the gap widens throughout school, reaching the equivalent of more than 19 months of learning by the end of secondary education.

“Despite decades of reform, I think the school system as we presently configure it may be beyond redemption,” Cremin said. “This isn’t an attack on the idea of education, or on the thousands of brilliant teachers who give the job their all. But government after government has tinkered with education when the basic model is obsolete.”

“If we keep preparing children for the second half of the 21st century using a system designed in the 19th, it could do catastrophic harm. We need to rethink what it means to educate, and what we are educating for.”

Rewilding Education challenges the ‘myth of social mobility’, arguing that education functions more as a sorting mechanism than a levelling force. High-performing school still admit disproportionately few disadvantaged young people, and poverty remains the strongest available predictor of student outcomes.

The chimerical belief persists that good grades will secure students a better future. “None of the ideas driving schools policy really stands up to scrutiny,” Cremin writes, “yet this hardly seems to matter”.

Cremin contends that schools often resemble outdated, factory-style production lines: rigid, standardised and with sometimes militaristic discipline. This, she suggests, suppresses curiosity, discourages critical thinking and disempowers teachers.

Her critique of the effects on physical and mental health is particularly urgent. Cremin argues that schools are making students and teachers ill. She presents evidence linking the loss of physical education and the sale of school playing fields to rising childhood obesity, and notes that even basic needs – such as access to adequate toilet facilities – often go unmet.

High-stakes testing, she adds, is fuelling poor mental health, while zero-tolerance behaviour policies have driven a 60% rise in permanent exclusions since 2015, with disadvantaged students four times more likely to be excluded. Students and teachers, she suggests, sometimes turn to medication to cope with an “ailing system”.

This bleak reality, she argues, demands more than incremental reform. The book calls for a new educational model for a new kind of future – one shaped by the climate crisis, downward mobility, Generative AI and post-truth politics. “We are educating for jobs and lifestyles that will soon cease to exist,” Cremin writes, “while failing to educate for those that don’t yet exist.”

This leads Cremin to call for education to be ‘rewilded’ – a metaphor drawn from ecological restoration. In schools, it implies letting go of rigid, one-size-fits-all structures, and allowing less predictable and more holistic forms of learning to emerge.

Nature plays a central role in her vision. Drawing on thinkers like Rabindranath Tagore, Cremin argues that schools should treat the natural world as a “co-educator”. She encourages outdoor and experience-based learning and suggests that even small changes – like planting trees, creating school gardens or nature-inspired arts activities – could help foster greater respect for the environment.

Rewilding Education also urges a rebalancing towards project-based learning, the arts and civic engagement. Students, Cremin argues, must learn not only to reproduce knowledge, but to act with wisdom and care, and to think critically about complex problems. This requires education for “body, mind, heart and soul”.

She proposes, for example, giving students time to walk and reflect when grappling with difficult questions, and highlights research linking later start times for adolescents – who have different sleep patterns – to better performance and wellbeing. She also champions mindfulness and ‘metacognitive’ approaches, that help children reflect on how they are thinking while they are learning.

In a chapter Cremin anticipates critics will deliberately misread, she calls for greater trust and deeper relationships between teachers and students. Risk aversion in schools, she argues, has counter-intuitively made it harder for teachers to care and support pupils, in favour of rule enforcement and teaching facts.

The book draws on examples from the UK, India, Germany and the US to show how ‘rewilding’ is not just possible, but already happening, in some schools that emphasise education for togetherness, harmony and wellbeing. “Something fundamental needs to change,” Cremin added. “We are crying out for systemic transformation: a completely new vision of what education involves, however challenging that may be.”



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source: cam.ac.uk

Diabetes drug and antihistamine could together repair multiple sclerosis damage, trial finds

Dr Nick Cunniffe running a “visual evoked potential” test with a trial participant in the Cambridge Clinical Vision Laboratory.
Dr Nick Cunniffe running a “visual evoked potential” test with a trial participant in the Cambridge Clinical Vision Laboratory.
Credit: MS Society

Scientists behind the trial say they are “on the brink of a new class of treatments” and that the findings take us another step closer to stopping disease progression in MS.

My instinct is that we are on the brink of a new class of treatments to stop MS progressionDr Nick Cunniffe

A combination of metformin, a common diabetes drug, and clemastine, an antihistamine, can help repair myelin – the protective coating around nerves, which gets damaged in multiple sclerosis (MS) causing symptoms like fatigue, pain, spasms and problems with walking.

This is according to early findings from the phase two clinical trial, CCMR-Two, carried out by researchers at the University of Cambridge’s Department of Clinical Neurosciences, and funded by the MS Society.

The scientists say the results take us another step closer to finally being able to stop disease progression in MS. However, they stress that people should not attempt to acquire the drugs outside a clinical trial, as further research is needed to fully understand their efficacy and safety in MS.

Previous evidence from animal studies showed that metformin enhances the effect of clemastine on myelin repair, but until now the two drugs had never been tested together in people. News of the latest trial was presented today at this year’s European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) – one of the world’s biggest MS research conferences.

“I am increasingly sure that remyelination is part of the solution to stopping progressive disability in MS,” said Dr Nick Cunniffe, a clinical lecturer in Neurology at Cambridge, who led the CCMR-Two trial.

“We still need to research the long-term benefits and side effects before people with MS consider taking these drugs. But my instinct is that we are on the brink of a new class of treatments to stop MS progression, and within the next decade we could see the first licensed treatment that repairs myelin and improves the lives of people living with MS.”

Over 150,000 people live with MS in the UK. While there are around 20 disease-modifying therapies for people with relapsing MS, and some emerging for active progressive MS, tens of thousands of people remain without effective treatment.

Those drugs that do exist only work on one aspect of the condition – the immune system. They don’t stop the gradual nerve damage that leads to long-term disability. Scientists say that protecting nerves from damage by boosting the body’s natural ability to put myelin back onto nerves could offer a way forward.  

“We desperately need ways to protect nerves from damage and repair lost myelin, and this research gives us real hope that myelin repair drugs will be part of the armoury of MS treatments in the future,” said Dr Emma Gray, Director of Research at the MS Society. “These results are truly exciting, and could represent a turning point in the way MS is treated.”

Some 70 people with relapsing MS took part in the trials for six months, half of whom took the drug combination and half took a placebo. The primary outcome used to gauge the effectiveness of the drug was a ‘visual evoked potential’ test, which measures how quickly signals travel between the eyes and the brain. The speed of signals slowed down in the placebo group over the course of six months, but remained constant in the drug group.

While the primary outcome was positive, scientists point out that people did not feel better on the drugs. The benefit from myelin repair is to insulate and protect damaged nerves, preventing them from degenerating over years. Researchers believe that drugs that promote remyelination will have an effect on disability in the long term, which will be the subject of further research.

Researchers argue that MS is just the beginning. Finding ways to protect the brain before irreversible damage sets in is vital across all neurodegenerative conditions, from Alzheimer’s to Parkinson’s. These diseases collectively cost the UK hundreds of billions and place an enormous burden on the NHS and carers.

Hannah Threlfell, 43, from Abington was diagnosed with relapsing MS in 2019 after experiencing optic neuritis. She joined the CCMR-Two trial in the hope she could help future generations.

“Before I was diagnosed, I sat through a talk from MS specialist Professor Alasdair Coles about groundbreaking MS research. Even though I didn’t know I had it then, I remember thinking how incredible it was that so much had been achieved. And now I have MS, joining the trial was a no brainer,” said Threlfall, a former teacher who has recently become a curate.

“I love helping and I know being on this trial will make a difference to someone else in the future – even small ripples have long-lasting effects! This research gives me even more reason to believe that in my lifetime everyone with MS will have treatments that work for them.”

CCMR-Two is being funded by donations to the MS Society’s Stop MS Appeal. The appeal hopes to raise £100 million by the end of 2025 to help find treatments that could slow or stop the build-up of disability for everyone with MS.



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source: cam.ac.uk

Cambridge marks centenary of IVF pioneer Sir Robert Edwards’ birth

Bob Edwards giving a talk at a symposium
Bob Edwards giving a talk at a Berlin symposium
Credit: Churchill Archives Centre

Celebrations at the University of Cambridge honour the life, work and legacy of Sir Robert Edwards, whose work revolutionised fertility treatment through the invention of in vitro fertilisation.

Scientists studying human reproduction at the University of Cambridge today are building on Sir Bob Edwards’ incredible legacy.Kathy Niakan

A Nobel prize-winner and one of the most influential scientists of the twentieth century, Edwards spent much of his career in the Department of Physiology at the University of Cambridge.

Together with gynaecologist Patrick Steptoe and technician and embryologist Jean Purdy, Edwards pioneered the technique of IVF, in which eggs are fertilised by sperm in a laboratory, creating an embryo that is transferred into a woman’s womb to achieve pregnancy.

Their breakthrough came when the first IVF baby, Louise Brown, was born in July 1978 – marking the beginning of a new era of medicine.

Researchers estimate there have now been over 13 million babies born from IVF worldwide.

A two-part event on Friday 26 September at the University of Cambridge will celebrate Edwards’ life, work and legacy, marking what would have been his 100th birthday on Saturday 27 September.

An afternoon of talks and discussion, focusing on science and clinical practice, will take part in the Physiology Lecture Theatre – the building where Edwards succeeding in fertilising a human egg in a test tube. It will involve clinicians and scientists who were trained or inspired by Edwards.

This will be followed by an evening panel discussion open to the public at Churchill College, Cambridge, where Edwards was a Fellow from 1979 and a Member from 1974.

Among the evening panellists will be Louise Brown – the first IVF baby, Dr Jenny Joy – the second of Edwards’ five daughters, Emma Barnett – British Broadcaster and Journalist with a young IVF child, and Dr Mike Macnamee – former CEO of the world’s first IVF clinic, Bourn Hall Clinic, which was established in 1980 by Edwards together with Steptoe and Purdy.

“Scientists studying human reproduction at the University of Cambridge today are building on Sir Bob Edwards’ incredible legacy. Many of their careers overlapped with his, and now they’re developing his science further, and also building on his pioneering contributions to the ethics of assisted reproduction,” said Professor Kathy Niakan, Director of the University of Cambridge’s Loke Centre for Trophoblast Research, who will chair the scientific sessions at Friday’s event.

She added: “To be part of this field today is a unique opportunity for discovery and innovation, and a great honour to carry forward Sir Bob Edwards’ vision in advancing our understanding of human reproduction.”

Dr Jenny Joy, Edwards’ daughter, said, “Our family is delighted to be involved in this event, working with the Loke Centre in the Physiology Department and Churchill College, which both meant a great deal to our father.”

Edwards joined the University of Cambridge in 1963, and went on to win the Nobel Prize in 2010 for his work, by which time around four million people had been born following IVF treatment. Edwards died in 2013, aged 87.

Infertility affects over 10% of all couples worldwide, and IVF is now one of the most commonly used and successful fertility treatments available.

More information about the event is available online.

The Bob Edwards centenary conference has been organised by the family of Sir Robert Edwards, the Loke Centre for Trophoblast Research, and Churchill Archives Centre (Churchill College) – which houses Edwards’ papers.

The conference is supported by Cambridge Reproduction.



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source: cam.ac.uk

Cambridge researchers named Fellows of the Royal Academy of Engineering

Cecilia Mascolo and Swami Swaminathan

Two Cambridge researchers have been named Fellows of the Royal Academy of Engineering in recognition of their exceptional contributions to their fields.

Professor Cecilia Mascolo, Professor of Mobile Systems in the Department of Computer Science and Technology and Professor Swami Swaminathan, Professor of Mechanical Engineering in the Department of Engineering, are among 74 leading figures in the field of engineering and technology elected to a Fellowship.

This year’s group consists of 60 Fellows, nine International Fellows and five Honorary Fellows.

They are drawn from every specialism from within the engineering and technology professions and cover sectors ranging from energy and defence to new materials. They have made exceptional contributions to their field: pioneering new innovations within academia and business, providing expert advice to government, and fostering a wider comprehension of engineering and technology.

Professor Cecilia Mascolo, who is also a Fellow of Jesus College, is a pioneer in devising frameworks to collect sensing data from devices such as phones and wearables with the purpose of developing models to understand behaviour and health. During the pandemic, she and her colleagues developed the COVID-19 Sounds App, which collects and analyses short recordings of users coughing and breathing to detect if they are suffering from COVID-19.

Since then, she has been working on ways to turn the devices we wear – such as earbuds – into mobile monitors that can collect data about our state of health, and developing cutting edge machine learning tools to evaluate that data on the device itself.

Professor Swami Swaminathan, who is also a Fellow of Robinson College, is an expert in the physics and chemistry of turbulent reacting flows, their modelling and simulations. His significant finding in turbulence-scalar-chemistry interaction led to a robust and accurate modelling framework enabling quantitative estimates of temperature distribution, emissions, combustion noise and instabilities in combustors using single simulation. His work helps engineers find robust designs of ‘green combustion systems’ for power generation using low- and zero-carbon fuel and helps devise simple models for complex fundamental phenomena.

This year’s new Fellows continue to reflect the Academy’s ongoing Fellowship Fit for the Future initiative announced in July 2020, to drive more nominations of outstanding engineers from underrepresented groups. This commits the Academy to strive for increased representation from women, disabled and LGBTQ+ engineers, those from minority ethnic backgrounds, non-traditional education pathways and emerging industries, and those who have achieved excellence at an earlier career stage than normal.

“As we approach our 50th anniversary next year it’s a good time to reflect on how much we have achieved,” said Sir John Lazar CBE FREng, President of the Royal Academy of Engineering. “The Academy is built on the foundation of our Fellowship, and that remains as true today as half a century ago.

“Today’s cohort join a community of around 1,700 of some of the most talented engineers and innovators in the UK and around the globe. Their knowledge and experience make them uniquely well placed to tackle the biggest challenges facing the world, and our determination to advance and promote excellence in engineering remains undimmed.”

The new Fellows will be formally admitted to the Academy at a ceremony in London on 18 November.



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source: cam.ac.uk

Cambridge spinout helping to make AI more trustworthy

Nigel Collier

As artificial intelligence becomes embedded in everyday tools and decisions, ensuring the safety and reliability of large language models (LLMs) is more critical than ever. Cambridge spinout Trismik has raised £2.2 million to help it make AI testing faster, smarter and more trustworthy.

AI is no longer just generating answers, it’s shaping decisions, products and lives. If we want trustworthy AI, we need to treat evaluation as seriously as we take training.Nigel Collier, Professor of Natural Language Processing and co-founder of Trismik

LLMs are powering more and more products, but testing their safety, reliability and performance is a significant challenge. Current testing methods are slow, manual and inconsistent, making it difficult for teams to iterate quickly or trust their results.

Trismik aims to solve this by using adaptive testing and automatic scoring to evaluate models against a number of dimensions including factual accuracy, bias and toxicity. Inspired by psychometrics and machine learning, the system dynamically selects the most informative test cases, dramatically reducing the number of datapoints required while achieving high reliability and enabling faster development cycles.

“AI is no longer just generating answers, it’s shaping decisions, products and lives. If we want trustworthy AI, we need to treat evaluation as seriously as we take training. Trismik aims to lead that charge by giving AI engineers the tools to test with precision, act with confidence and build with integrity,” said Nigel Collier, Professor of Natural Language Processing at the University of Cambridge and co-founder and Chief Scientist at Trismik.

Collier, who started his career in the 1990s with a PhD in machine translation using neural networks, has increasingly focused on how we can ensure AI acts as a trusted partner to humanity rather than a risk to it. Collier’s curiosity for whether AI could be assessed in the same efficient and fair way as humans, created the genesis for Trismik’s approach to adaptive evaluation.

In 2023 Collier met co-founder Rebekka Mikkola, a repeat founder and enterprise sales executive with a passion both for building in AI and opening doors for women in tech. The pair were backed early by Cambridge Enterprise and in 2025 were joined by former Amazon scientist Marco Basaldella as CTO, completing a founding team that blends science, engineering and commercial expertise.

Dr Christine Martin, Head of Ventures at Cambridge Enterprise, said: “Trismik exemplifies Cambridge’s continued contribution to global AI development with the team combining world-class academic credentials and practical industry experience that has given them the unique authority to define how AI capabilities should be measured. By solving a pivotal challenge in AI adoption, Trismik is positioned to drive trust at scale – we’re excited to support their journey to market.”

The £2.2m in pre-seed financing was led by Twinpath Ventures, with participation from Cambridge Enterprise Ventures, Parkwalk Advisors, Fund F, Vento Ventures and angel investors from Ventures Together.

Read the full news story on the Cambridge Enterprise website.



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source: cam.ac.uk

New Encode Fellowships boost AI research at Cambridge

A person's hand touches an illustration of digital data.
People and Artificial Intelligence
Credit: Weiquan Lin

Cambridge scientists are using artificial intelligence technology to boost research in a range of fields – from better understanding human intelligence, to describing turbulent flows, to freeing computer systems from the cloud – after securing new Fellowships launched to drive breakthrough discoveries.

The Encode: AI for Science Fellowships embed top AI talent in the UK’s leading labs to tackle scientific challenges and accelerate the path to real-world solutions. Three Fellowships in the first cohort are being hosted at Cambridge.

Encode Fellow Jonathan Carter is using technology originally developed for astrophysics research to decipher how humans understand physics – for example, how the human brain performs intuitive physics calculations, like predicting where a thrown ball will land. Working with Hiranya Peiris, who holds the Cambridge Professorship of Astrophysics (1909), their approach uses interpretable variational encoders, a specialised neural network that can find compact, meaningful representations in complex data. This cross-disciplinary research could advance both our understanding of human intelligence and our ability to build AI systems that learn and generalise like humans do.

Shruti Mishra, another Encode Fellow, is developing an AI system that can discover clear, understandable equations describing how turbulent flows behave across different scales. This is a long-standing challenge in physics that affects everything from weather prediction to aerospace design. Guided by Miles Cranmer, Assistant Professor of Data Intensive Science at Cambridge, Shruti is combining machine learning with symbolic mathematics to automatically produce equations that scientists can interpret and trust, rather than ‘black-box predictions’, where the decision-making process is difficult to understand. Their work has the potential to enable more accurate climate predictions and improve industrial designs.

And Encode Fellow Martyna Stachaczyk is working with Rika Antonova, Associate Professor at Cambridge, to design a biologically inspired, on-device control architecture for real-time, local intelligence. This research could free intelligent systems from the cloud – which can be insecure and inaccessible where connectivity is limited – enabling robust, adaptive autonomy for prosthetics, robots, and environmental platforms even in resource-constrained or disconnected settings.

The Encode AI for Science Fellowship programme is run by Pillar VC, with funding from the Advanced Research + Invention Agency (ARIA) and the UK Government’s Sovereign AI Unit.



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source: cam.ac.uk

Artificial heart valve found to be safe following long-term test in animals

SEBS polymer artificial heart valve prototype
SEBS polymer artificial heart valve prototype
Credit: Professor Raimondo Ascione, University of Bristol

An artificial heart valve made from a new type of plastic could be a step closer to use in humans, following a successful long-term safety test in animals.

A research team, led by the Universities of Bristol and Cambridge, demonstrated that the polymer material used to make the artificial heart valve is safe following a six-month test in sheep.

Currently, the 1.5 million patients who need heart valve replacements each year face trade-offs. Mechanical heart valves are durable but require lifelong blood thinners due to a high risk of blood clots, whereas biological valves, made from animal tissue, typically last between eight to 10 years before needing replacement.

The artificial heart valve developed by the researchers is made from SEBS (styrene-block-ethylene/butyleneblock-styrene) – a type of plastic that has excellent durability but does not require blood thinners – and potentially offers the best of both worlds. However, further testing is required before it can be tested in humans.

In their study, published in the European Journal of Cardio-Thoracic Surgery, the researchers tested a prototype SEBS heart valve in a preclinical sheep model that mimicked how these valves might perform in humans.

The animals were monitored over six months to examine potential long-term safety issues associated with the plastic material. At the end of the study, the researchers found no evidence of harmful calcification (mineral buildup) or material deterioration, blood clotting or signs of cell toxicity. Animal health, wellbeing, blood tests and weight were all stable and normal, and the prototype valve functioned well throughout the testing period, with no need for blood thinners.

“More than 35 million patients’ heart valves are permanently damaged by rheumatic fever, and with an ageing population, this figure is predicted to increase four to five times by 2050,” said Professor Raimondo Ascione from the University of Bristol, the study’s clinical lead. “Our findings could mark the beginning of a new era for artificial heart valves: one that may offer safer, more durable and more patient-friendly options for patients of all ages, with fewer compromises.”

“We are pleased that the new plastic material has been shown to be safe after six months of testing in vivo,” said Professor Geoff Moggridge from Cambridge’s Department of Chemical Engineering and Biotechnology, biomaterial lead on the project. “Confirming the safety of the material has been an essential and reassuring step for us, and a green light to progress the new heart valve replacement toward bedside testing.”

The results suggest that artificial heart valves made from SEBS are both durable and do not require the lifelong use of blood thinners.

While the research is still early-stage, the findings help clear a path to future human testing. The next step will be to develop a clinical-grade version of the SEBS polymer heart valve and test it in a larger preclinical trial before seeking approval for a pilot human clinical trial.

The study was funded by a British Heart Foundation (BHF) grant and supported by a National Institute for Health and Care Research (NIHR) Invention for Innovation (i4i) programme Product Development Awards (PDA) award. Geoff Moggridge is a Fellow of King’s College, Cambridge. 

Reference:
Raimondo Ascione et al. ‘Material safety of styrene-block-ethylene/butylene-block-styrene copolymers used for cardiac valves: 6-month in-vivo results from a juvenile sheep model’. European Journal of Cardio-Thoracic Surgery (2025). DOI: 10.1093/ejcts/ezaf266/ejcts-2025-100426

Adapted from a University of Bristol media release. 



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source: cam.ac.uk

Cambridge to host cutting-edge total-body PET scanner as part of nationwide imaging platform

Siemens Healthineers Biograph Vision Quadra Total-Body PET Scanner
Siemens Healthineers Biograph Vision Quadra Total-Body PET Scanner
Credit: Siemens Healthineers

A new total-body PET scanner to be hosted in Cambridge – one of only a handful in the country – will transform our ability to diagnose and treat a range of conditions in patients and to carry out cutting-edge research and drug development.

This is an exciting new technology that will transform our ability to answer important questions about how diseases arise and to search for and develop new treatmentsFranklin Aigbirhio

The scanner, funded through a £5.5m investment from the UKRI Medical Research Council (MRC), will form part of the National PET Imaging Platform (NPIP), the UK’s first-of-its-kind national total-body PET imaging platform for drug discovery and clinical research.

Positron emission tomography (PET) is a powerful technology for imaging living tissues and organs down to the molecular level in humans. It can be used to investigate how diseases arise and progress and to detect and diagnose diseases at an early stage.

Total-body PET scanners are more sensitive than existing technology and so can provide new insights into anatomy that have never been seen before, improving detection, diagnosis and treatment of complex, multi-organ diseases.

Current PET technology is less sensitive and requires the patient to be repositioned multiple times to achieve a full-body field of view. Total-body PET scans can achieve this in one session and are quicker, exposing patients to considerably lower doses of radiation. This means more patients, including children, can participate in clinical research and trials to improve our understanding of diseases.

ANGLIA network of universities and NHS trusts

Supplied by Siemens Healthineers, the scanner will also be the focus of the ANGLIA network, comprising three universities, each paired with one or more local NHS trusts: the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust; UCL and University College London Hospitals NHS Foundation Trust; and the University of Sheffield with Sheffield Teaching Hospitals NHS Foundation Trust.

The network, supported by UKRI, is partnered with biotech company Altos Labs and pharmaceutical company AstraZeneca, both with R&D headquarters in Cambridge, and Alliance Medical, a leading provider of diagnostic imaging.

Franklin Aigbirhio, Professor of Molecular Imaging Chemistry at the University of Cambridge, will lead the ANGLIA network. He said: “This is an exciting new technology that will transform our ability to answer important questions about how diseases arise and to search for and develop new treatments that will ultimately benefit not just our patients, but those across the UK and beyond.

“But this is more than just a research tool. It will also help us diagnose and treat diseases at an even earlier stage, particularly in children, for whom repeated investigations using standard PET scanners were not an option.”

The scanner will be located in Addenbrooke’s Hospital, Cambridge, supported by the National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre, ensuring that the discoveries and breakthroughs it enables can be turned rapidly into benefits to patients. It will expand NHS access to PET services, particularly in underserved areas across the East of England, and support more inclusive trial participation.

Patrick Maxwell, Regius Professor of Physic and Head of the School of Clinical Medicine at the University of Cambridge, said: “The ANGLIA network, centred on the Cambridge Biomedical Campus and with collaborations across the wider University and its partners, will drive innovations in many areas of this key imaging technology, such as new radiopharmaceuticals and application of AI to data analysis, that will bring benefits to patients far beyond its immediate reach. Its expertise will help build the next generation of PET scientists, as well as enabling partners in industry to use PET to speed up the development of new drugs.”

Roland Sinker, Chief Executive of Cambridge University Hospitals NHS Foundation Trust, which runs Addenbrooke’s Hospital, said: “I am pleased that our patients will be some of the first to benefit from this groundbreaking technology. Harnessing the latest technologies and enabling more people to benefit from the latest research is a vital part of our work at CUH and is crucial to the future of the NHS.

“By locating this scanner at Addenbrooke’s we are ensuring that it can be uniquely used to deliver wide ranging scientific advances across academia and industry, as well as improving the lives of patients.”

It is anticipated that the scanner will be installed by autumn 2026.

Professor Franklin Aigbirhio

Professor Franklin Aigbirhio
Professor Franklin Aigbirhio

Enhancing training and research capacity

The co-location of the total-body PET scanner with existing facilities and integration with systems at the University of Cambridge and Addenbrooke’s Hospital will also enhance training and research capacity, particularly for early-career researchers and underrepresented groups.

The ANGLIA network will provide opportunities to support and train more by people from Black and other minority ethnic backgrounds to participate in PET chemistry and imaging. The University of Cambridge will support a dedicated fellowship scheme, capacity and capability training in key areas, and strengthen the network partnership with joint projects and exchange visits.

Professor Aigbirhio, who is also co-chair of the UKRI MRC’s Black in Biomedical Research Advisory Group, added: “Traditionally, scientists from Black and other minority ethnic backgrounds are under-represented in the field of medical imaging. We aim to use our network to change this, providing fellowship opportunities and training targeted at members of these communities.”

The National PET Imaging Platform

Funded by UKRI’s Infrastructure Fund, and delivered by a partnership between Medicines Discovery Catapult, MRC and Innovate UK, NPIP provides a critical clinical infrastructure of scanners, creating a nationwide network for data sharing, discovery and innovation. It allows clinicians, industry and researchers to collaborate on an international scale to accelerate patient diagnosis, treatment and clinical trials. The MRC funding for the Cambridge scanner will support the existing UKRI Infrastructure Fund investment for NPIP and enables the University to establish a total-body PET facility.

Dr Ceri Williams, Executive Director of Challenge-Led Themes at MRC said: “MRC is delighted to augment the funding for NPIP to provide an additional scanner for Cambridge in line with the original recommendations of the funding panel. This additional machine will broaden the geographic reach of the platform, providing better access for patients from East Anglia and the Midlands, and enable research to drive innovation in imaging, detection, and diagnosis, alongside supporting partnership with industry to drive improvements and efficiency for the NHS.”

Dr Juliana Maynard, Director of Operations and Engagement for the National PET Imaging Platform, said: “We are delighted to welcome the University of Cambridge as the latest partner of NPIP, expanding our game-changing national imaging infrastructure to benefit even more researchers, clinicians, industry partners and, importantly, patients.

“Once operational, the scanner will contribute to NPIP’s connected network of data, which will improve diagnosis and aid researchers’ understanding of diseases, unlocking more opportunities for drug discovery and development. By fostering collaboration on this scale, NPIP helps accelerate disease diagnosis, treatment, and clinical trials, ultimately leading to improved outcomes for patients.”



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Farming Minister and local MP tours Sainsbury Laboratory and sees leading Cambridge Agri-Tech research 

The University of Cambridge hosted a visit from local MP, and Farming Minister Daniel Zeichner MP, at the Sainsbury Laboratory.

The visit brought together fundamental plant science research with crop and Agri-Tech researchers from across the University for a series of research demonstrations and a roundtable discussion. 

Mr Zeichner toured the award-winning facility, meeting researchers in the open-plan office and lab spaces, which foster collaboration and advances in multi-disciplinary research. 

The Minister saw exciting examples of foundational research, which have the potential to transform agriculture and ensure long term sustainability.  

The first demonstration was led by Dr Sebastian Schornack and PhD student Nicolas Hernandez, who are investigating the plant developmental processes. The Minister saw through the microscope how they are using beetroot pigments to enable us to see how fungi is colonising living plant roots. This research allows us to track and measure in real time how chemicals, soil tillage and environmental conditions impact this beneficial plant-microbe relationship.  

Mr Zeichner then visited the Lab’s microscopy room, and met with Dr Madelaine Bartlett and her colleague Terice Kelly. Dr Madelaine Bartlett’s team researches the development of maize flowers (among other grass and cereal species) with a particular focus on the genetics behind these specialised flowers and future crop improvement. The team demonstrated how they image a maize flower on the Lab’s desktop scanning electron microscope. 

The Sainsbury Laboratory boasts its own Bee Room, where Dr Edwige Moyroud demonstrated how bumble bees are helping to reveal the characteristics of petal patterns that are most important for attracting pollinators. Dr Moyroud and her team are identifying the genes that plants use to produce patterns that attract pollinators by combining various research techniques, including experiments, modelling, microscopy and bee behaviour. 

Finally, overlooking Cambridge’ Botanic Gardens, academics from the Department of Plant Sciences and the Crop Science Centre presented on research into regenerative agriculture and using AI to measure and prevent crop disease.  

Professor Lynn Dicks presented on the latest findings of the H3 research on regenerative agriculture. Professor Dicks and colleagues, during this ongoing five-year project, have worked collaboratively with farming clusters in the UK to study the impacts of a transition on regenerative agriculture, which has so far has been shown to improve soil health and reduce the use of chemicals. 

Professor Eves-van Den Akker and his team, based at the University’s Crop Science Centre, have combined low-cost 3D printing of custom imaging machines with state-of-the-art deep-learning algorithms to make millions of measurements, of tens of thousands of parasites across hundreds of genotypes. They are now working with companies to translate this fundamental research, with the aim of accelerating their breeding programs for crop resistance to pests and disease. 

The visit concluded with a discussion of the UK’s leading strengths in Agri-Tech and crop science, and how the UK and Cambridge are an attractive place for researchers from around the world to work, and make exciting advances, with global impact. 



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Depression linked to presence of immune cells in the brain’s protective layer

Silhouette photography of man
Silhouette photography of man
Credit: Gift Habeshaw (Unsplash)

Immune cells released from bone marrow in the skull in response to chronic stress and adversity could play a key role in symptoms of depression and anxiety, say researchers.

There’s a significant proportion of people for whom antidepressants don’t work. If we can figure out what’s happening with the immune system, we may be able to alleviate or reduce depressive symptomsStacey Kigar

The discovery – found in a study in mice – sheds light on the role that inflammation can play in mood disorders and could help in the search for new treatments, in particular for those individuals for whom current treatments are ineffective.

Around 1 billion people will be diagnosed with a mood disorder such as depression or anxiety at some point in their life. While there may be many underlying causes, chronic inflammation – when the body’s immune system stays active for a long time, even when there is no infection or injury to fight – has been linked to depression. This suggests that the immune system may play an important role in the development of mood disorders.

Previous studies have highlighted how high levels of an immune cell known as a neutrophil, a type of white blood cell, are linked to the severity of depression. But how neutrophils contribute to symptoms of depression is currently unclear.

In research published today in Nature Communications, a team led by scientists at the University of Cambridge, UK, and the National Institute of Mental Health, USA, tested a hypothesis that chronic stress can lead to the release of neutrophils from bone marrow in the skull. These cells then collect in the meninges – membranes that cover and protect your brain and spinal cord – and contribute to symptoms of depression.

As it is not possible to test this hypothesis in humans, the team used mice exposed to chronic social stress. In this experiment, an ‘intruder’ mouse is introduced into the home cage of an aggressive resident mouse. The two have brief daily physical interactions and can otherwise see, smell, and hear each other.

The researchers found that prolonged exposure to this stressful environment led to a noticeable increase in levels of neutrophils in the meninges, and that this was linked to signs of depressive behaviour in the mice. Even after the stress ended, the neutrophils lasted longer in the meninges than they did in the blood. Analysis confirmed the researchers’ hypothesis that the meningeal neutrophils – which appeared subtly different from those found in the blood – originated in the skull.

Further analysis suggested that long-term stress triggered a type of immune system ‘alarm warning’ known as type I interferon signalling in the neutrophils. Blocking this pathway – in effect, switching off the alarm – reduced the number of neutrophils in the meninges and improved behaviour in the depressed mice. This pathway has previously been linked to depression – type 1 interferons are used to treat patients with hepatitis C, for example, but a known side effect of the medication is that it can cause severe depression during treatment.

Dr Stacey Kigar from the Department of Medicine at the University of Cambridge said: “Our work helps explain how chronic stress can lead to lasting changes in the brain’s immune environment, potentially contributing to depression. It also opens the door to possible new treatments that target the immune system rather than just brain chemistry.

“There’s a significant proportion of people for whom antidepressants don’t work, possibly as many as one in three patients. If we can figure out what’s happening with the immune system, we may be able to alleviate or reduce depressive symptoms.”

The reason why there are high levels of neutrophils in the meninges is unclear. One explanation could be that they are recruited by microglia, a type of immune cell unique to the brain. Another possible explanation is that chronic stress may cause microhaemorrhages, tiny leaks in brain blood vessels, and that neutrophils – the body’s ‘first responders’ – arrive to fix the damage and prevent any further damage. These neutrophils then become more rigid, possibly getting stuck in brain capillaries and causing further inflammation in the brain.

Dr Mary-Ellen Lynall from the Department of Psychiatry at the University of Cambridge said: “We’ve long known that something is different about how neutrophils behave after stressful events, or during depression, but we didn’t know what these neutrophils were doing, where they were going, or how they might be affecting the brain and mind. Our findings show that these ‘first responder’ immune cells leave the skull bone marrow and travel to the brain, where they can influence mood and behaviour.

“Most people will have experienced how our immune systems can drive short-lived depression-like symptoms. When we are sick, for example with a cold or flu, we often lack energy and appetite, sleep more and withdraw from social contact. If the immune system is always in a heightened, pro-inflammatory state, it shouldn’t be too surprising if we experience longer-term problems with our mood.”

The findings could provide a useful signature, or ‘biomarker’, to help identify those patients whose mood disorders are related to inflammation. This could help in the search for better treatments. For example, a clinical trial of a potential new drug that targets inflammation of the brain in depression might appear to fail if trialled on a general cohort of people with depression, whereas using the biomarker to identify individuals whose depression is linked to inflammation could increase the likelihood of the trial succeeding.

The findings may also help explain why depression is a symptom common in other neurological disorders such as stroke and Alzheimer’s disease, as it may be the case that neutrophils are being released in response to the damage to the brain seen in these conditions. But it may also explain why depression is itself a risk factor for dementia in later life, if neutrophils can themselves trigger damage to brain cells.

The research was funded by the National Institute of Mental Health, Medical Research Council and National Institute for Health and Care Research Cambridge Biomedical Research Centre.

Reference
Kigar, SL et al. Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice. Nat Comms; 1 Sept 2025; DOI: 10.1038/s41467-025-62840-5



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Trump shooting and Biden exit flipped social media from hostility to solidarity

The Trump assassination attempt on the front page of German newspaper Bild.
The Trump assassination attempt on the front page of German newspaper Bild.
Credit: conceptphoto.info via Flickr

Research reveals how political crises cause a shift in the force behind viral online content ‘from outgroup hate to ingroup love’.

It appears that political crises evoke not so much outgroup hate but rather ingroup loveMalia Marks

While previous research shows outrage and division drive engagement on social media, a new study of digital behaviour during the 2024 US election finds that this effect flips during a major crisis – when “ingroup solidarity” becomes the engine of online virality.

Psychologists say the findings show positive emotions such as unity can cut through the hostility on social media, but it takes a shock to the system that threatens a community.  

In a little over a week during the summer of 2024, the attempted assassination of Donald Trump at a rally (July 13) and Joe Biden’s suspension of his re-election campaign (21 July) completely reshaped the presidential race.

The University of Cambridge’s Social Decision-Making Lab collected over 62,000 public posts from the Facebook accounts of hundreds of US politicians, commentators and media outlets before and after these events to see how they affected online behaviour.*

“We wanted to understand the kinds of content that went viral among Republicans and Democrats during this period of high tension for both groups,” said Malia Marks, PhD candidate in Cambridge’s Department of Psychology and lead author of the study, published in the journal Proceedings of the National Academy of Sciences.

“Negative emotions such as anger and outrage along with hostility towards opposing political groups are usually rocket fuel for social media engagement. You might expect this to go into hyperdrive during times of crisis and external threat.”

“However, we found the opposite. It appears that political crises evoke not so much outgroup hate but rather ingroup love,” said Marks.

Just after the Trump assassination attempt, Republican-aligned posts signalling unity and shared identity received 53% more engagement than those that did not – an increase of 17 percentage points compared to just before the shooting.

These included posts such as evangelist Franklin Graham thanking God that Donald Trump is alive, and Fox News commentator Laura Ingraham posting: “Bleeding and unbowed, Trump faces relentless attacks yet stands strong for America. This is why his followers remain passionately loyal.”

At the same time, engagement levels for Republican posts attacking the Democrats saw a decrease of 23 percentage points from just a few days earlier.

After Biden suspended his re-election campaign, Democrat-aligned posts expressing solidarity received 91% more engagement than those that did not – a major increase of 71 percentage points over the period shortly before his withdrawal.

Posts included former US Secretary of Labor Robert Reich calling Biden “one of our most pro-worker presidents”, and former House Speaker Nancy Pelosi posting that Biden’s “legacy of vision, values and leadership make him one of the most consequential Presidents in American history.”

Biden’s withdrawal saw the continuation of a gradual rise in engagement for Democrat posts attacking Republicans – although over the 25 July days covered by the analysis almost a quarter of all conservative posts displayed “outgroup hostility” compared to just 5% of liberal posts.

Research led by the same Cambridge Lab, published in 2021, showed how social media posts criticizing or mocking those on the rival side of an ideological divide typically receive twice as many shares as posts that champion one’s own side.

“Social media platforms such as Twitter and Facebook are increasingly seen as creating toxic information environments that intensify social and political divisions, and there is plenty of research now to support this,” said Yara Kyrychenko, study co-author and PhD candidate in Cambridge’s Social Decision-Making Lab.

“Yet we see that social media can produce a rally-round-the-flag effect at moments of crisis, when the emotional and psychological preference for one’s own group takes over as the dominant driver of online behaviour.”

Last year, the Cambridge team (led by Kyrychenko) published a study of 1.6 million Ukrainian social media posts in the months before and after Russia’s full-scale invasion in February of 2022.

Following the invasion they found a similar spike for “ingroup solidarity” posts, which got 92% more engagement on Facebook and 68% more on Twitter, while posts hostile to Russia received little extra engagement. 

Researchers argue that the findings from the latest study are even more surprising, given the gravity of the threat to Ukraine and the nature of its population.

“We didn’t know whether moments of political rather than existential crisis would trigger solidarity in a country as deeply polarised as the United States. But even here, group unity surged when leadership was threatened,” said Dr Jon Roozenbeek, Lecturer in Psychology at Cambridge University and senior author of the study.

“In times of crisis, ingroup love may matter more to us than outgroup hate on social media.”


* The study used 62,118 public posts from 484 Facebook accounts run by US politicians and partisan commentators or media sources from 5-29 July 2024.



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Gone but not forgotten: brain’s map of the body remains unchanged after amputation

Emily Wheldon, tested before and after her arm amputation surgery
Emily Wheldon, tested before and after her arm amputation surgery
Credit: Tamar Makin / Hunter Schone

The brain holds a ‘map’ of the body that remains unchanged even after a limb has been amputated, contrary to the prevailing view that it rearranges itself to compensate for the loss, according to new research from scientists in the UK and US.

We suspected that the brain maps would be largely unchanged, but the extent to which the map of the missing limb remained intact was jaw-droppingTamar Makin

The findings, published today in Nature Neuroscience, have implications for the treatment of ‘phantom limb’ pain, but also suggest that controlling robotic replacement limbs via neural interfaces may be more straightforward than previously thought.

Studies have previously shown that within an area of the brain known as the somatosensory cortex there exists a map of the body, with different regions corresponding to different body parts. These maps are responsible for processing sensory information, such as touch, temperate and pain, as well as body position. For example, if you touch something hot with your hand, this will activate a particular region of the brain; if you stub your toe, a different region activates.

For decades now, the commonly-accepted view among neuroscientists has been that following amputation of a limb, neighbouring regions rearrange and essentially take over the area previously assigned to the now missing limb. This has relied on evidence from studies carried out after amputation, without comparing activity in the brain maps beforehand.

But this has presented a conundrum. Most amputees report phantom sensations, a feeling that the limb is still in place – this can also lead to sensations such as itching or pain in the missing limb. Also, brain imaging studies where amputees have been asked to ‘move’ their missing fingers have shown brain patterns resembling those of able-bodied individuals.

To investigate this contradiction, a team led by Professor Tamar Makin from the University of Cambridge and Dr Hunter Schone from the University of Pittsburgh followed three individuals due to undergo amputation of one of their hands. This is the first time a study has looked at the hand and face maps of individuals both before and after amputation. Most of the work was carried out while Professor Makin and Dr Schone were at UCL.

Prior to amputation, all three individuals were able to move all five digits of their hands. While lying in a functional magnetic resonance imaging (fMRI) scanner – which measures activity in the brain – the participants were asked to move their individual fingers and to purse their lips. The researchers used the brain scans to construct maps of the hand and lips for each individual. In these maps, the lips sit near to the hand.

The participants repeated the activity three months and again six months after amputation, this time asked to purse their lips and to imagine moving individual fingers. One participant was scanned again 18 months after amputation and a second participant five years after amputation.

The researchers examined the signals from the pre-amputation finger maps and compared them against the maps post-amputation. Analysis of the ‘before’ and ‘after’ images revealed a remarkable consistency: even with their hand now missing, the corresponding brain region activated in an almost identical manner.

Professor Makin, from the Medical Research Council Cognition and Brain Science Unit at the University of Cambridge, the study’s senior author, said: “Because of our previous work, we suspected that the brain maps would be largely unchanged, but the extent to which the map of the missing limb remained intact was jaw-dropping.

“Bearing in mind that the somatosensory cortex is responsible for interpreting what’s going on within the body, it seems astonishing that it doesn’t seem to know that the hand is no longer there.”

As previous studies had suggested that the body map reorganises such that neighbouring regions take over, the researchers looked at the region corresponding to the lips to see if it had moved or spread. They found that it remained unchanged and had not taken over the region representing the missing hand.

The study’s first author, Dr Schone from the Department of Physical Medicine and Rehabilitation, University of Pittsburgh, said: “We didn’t see any signs of the reorganisation that is supposed to happen according to the classical way of thinking. The brain maps remained static and unchanged.”

To complement their findings, the researchers compared their case studies to 26 participants who had had upper limbs amputated, on average 23.5 years beforehand. These individuals showed similar brain representations of the hand and lips to those in their three case studies, suggesting long-term evidence for the stability of hand and lip representations despite amputation.

illustration1.jpg

Brain activity maps for the hand (shown in red) and lips (blue) before and after amputation
Brain activity maps for the hand (shown in red) and lips (blue) before and after amputation

The researchers offer an explanation for the previous misunderstanding of what happens within the brain following amputation. They say that the boundaries within the brain maps are not clear cut – while the brain does have a map of the body, each part of the map doesn’t support one body part exclusively. So while inputs from the middle finger may largely activate one region, they also show some activity in the region representing the forefinger, for example. Previous studies that argue for massive reorganisation determined the layout of the maps by applying a ‘winner takes all’ strategy – stimulating the remaining body parts and noting which area of the brain shows most activity; because the missing limb is no longer there to be stimulated, activity from neighbouring limbs has been misinterpreted as taking over.

The findings have implications for the treatment of phantom limb pain, a phenomenon that can plague amputees. Current approaches focus on trying to restore representation of the limb in the brain’s map, but randomised controlled trials to test this approach have shown limited success – today’s study suggests this is because these approaches are focused on the wrong problem.

Dr Schone said: “The remaining parts of the nerves — still inside the residual limb — are no longer connected to their end-targets. They are dramatically cut off from the sensory receptors that have delivered them consistent signals. Without an end-target, the nerves can continue to grow to form a thickening of the nerve tissue and send noisy signals back to the brain.

“The most promising therapies involve rethinking how the amputation surgery is actually performed, for instance grafting the nerves into a new muscle or skin, so they have a new home to attach to.”

Of the three participants, one had substantial limb pain prior to amputation but received a complex procedure to graft the nerves to new muscle or skin; she no longer experiences pain. The other two participants, however, received the standard treatment and continue to experience phantom limb pain.

The University of Pittsburgh is one of a number of institutions that is researching whether movement and sensation can be restored to paralysed limbs or whether amputated limbs might be replaced by artificial, robotic limbs controlled by a brain interface. Today’s study suggests that because the brain maps are preserved, it should – in theory – be possible to restore movement to a paralysed limb or for the brain to control a prosthetic.

Dr Chris Baker from the Laboratory of Brain & Cognition, National Institutes of Mental Health, said: “If the brain rewired itself after amputation, these technologies would fail. If the area that had been responsible for controlling your hand was now responsible for your face, these implants just wouldn’t work. Our findings provide a real opportunity to develop these technologies now.”

Dr Schone added: “Now that we’ve shown these maps are stable, brain-computer interface technologies can operate under the assumption that the body map remains consistent over time. This allows us to move into the next frontier: accessing finer details of the hand map — like distinguishing the tip of the finger from the base — and restoring the rich, qualitative aspects of sensation, such as texture, shape, and temperature. This study is a powerful reminder that even after limb loss, the brain holds onto the body, waiting for us to reconnect.”

The research was supported by Wellcome, the National Institute of Mental Health, National Institutes of Health and Medical Research Council.

Reference

Schone, HR et al. Stable Cortical Body Maps Before and After Arm Amputation. Nature Neuroscience; 21 Aug 2025; DOI: 10.1038/s41593-025-02037-7



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Long-term exposure to outdoor air pollution linked to increased risk of dementia

Traffic jam
Traffic jam
Credit: joiseyshowaa

An analysis of studies incorporating data from almost 30 million people has highlighted the role that air pollution – including that coming from car exhaust emissions – plays in increased risk of dementia.

Tackling air pollution can deliver long-term health, social, climate, and economic benefitsHaneen Khreis

Dementias such as Alzheimer’s disease are estimated to affect more than 57.4 million people worldwide, a number that is expected to almost triple to 152.8 million cases by 2050. The impacts on the individuals, families and caregivers and society at large are immense.

While there are some indications that the prevalence of dementia is decreasing in Europe and North America, suggesting that it may be possible to reduce the risk of the disease at a population level, elsewhere the picture is less promising.

Air pollution has recently been identified as a risk factor for dementia, with several studies pointing the finger at a number of pollutants. However, the strength of evidence and ability to determine a causal effect has been varied.

In a paper published today in The Lancet Planetary Health, a team led by researchers at the Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, carried out a systematic review and meta-analysis of existing scientific literature to examine this link further. This approach allowed them to bring together studies that on their own may not provide sufficient evidence, and which sometimes disagree with each other, to provide more robust overarching conclusions.

In total, the researchers included 51 studies, including data from more than 29 million participants who had been exposed to air pollutants for at least one year, mostly from high-income countries. Of these, 34 papers were included in the meta-analysis: 15 originated in North America, 10 in Europe, seven in Asia, and two in Australia.

The researchers found a positive and statistically-significant association between three types of air pollutant and dementia. These were:

  • Particulate matter with a diameter of 2.5 microns or less (PM2.5), a pollutant made up of tiny particles small enough that they can be inhaled deep into the lungs. These particles come from several sources, including vehicle emissions, power plants, industrial processes, wood burning stoves and fireplaces, and construction dust. They also form in the atmosphere because of complex chemical reactions involving other pollutants such as sulphur dioxide and nitrogen oxides. The particles can stay in the air for a long time and travel a long way from where they were produced.
  • Nitrogen dioxide (NO2), one of the key pollutants that arise from burning fossil fuels. It is found in vehicle exhaust, especially diesel exhaust, and industrial emissions, as well as those from gas stoves and heaters. Exposure to high concentrations of nitrogen dioxide can irritate the respiratory system, worsening and inducing conditions like asthma and reducing lung function.
  • Soot from sources such as vehicle exhaust emissions and burning wood. It can trap heat and affect the climate. When inhaled, it can penetrate deep into the lungs, aggravating respiratory diseases and increasing the risk of heart problems.

According to the researchers, for every 10 micrograms per cubic meter (μg/m³) of PM2.5, an individual’s relative risk of dementia would increase by 17%. The average roadside measurement for PM2.5 in Central London in 2023 was 10 μg/m³.

For every 10 μg/m3 of NO2, the relative risk increased by 3%. The average roadside measurement for NO2 in Central London in 2023 was 33 µg/m³.

For each 1 μg/m³ of soot as found in PM2.5, the relative risk increased by 13%. Across the UK, annual mean soot concentrations measured at select roadside locations in 2023 were 0.93 μg/m³ in London, 1.51 μg/m³ in Birmingham and 0.65 μg/m³ in Glasgow.

Senior author Dr Haneen Khreis from the MRC Epidemiology Unit said: “Epidemiological evidence plays a crucial role in allowing us to determine whether or not air pollution increases the risk of dementia and by how much. Our work provides further evidence to support the observation that long-term exposure to outdoor air pollution is a risk factor for the onset of dementia in previously healthy adults.

“Tackling air pollution can deliver long-term health, social, climate, and economic benefits. It can reduce the immense burden on patients, families, and caregivers, while easing pressure on overstretched healthcare systems.”

Several mechanisms have been proposed to explain how air pollution may cause dementia, primarily involving inflammation in the brain and oxidative stress (a chemical process in the body that can cause damage to cells, proteins, and DNA). Both oxidative stress and inflammation play a well-established role in the onset and progression of dementia. Air pollution is thought to trigger these processes through direct entry to the brain or via the same mechanisms underlying lung and cardiovascular diseases. Air pollution can also enter circulation from the lungs and travel to solid organs, initiating local and wide-spread inflammation.

The researchers point out that the majority of people included in the published studies were white and living in high-income countries, even though marginalised groups tend to have a higher exposure to air pollution. Given that studies have suggested that reducing air pollution exposure appears to be more beneficial at reducing the risk of early death for marginalised groups, they call for future work to urgently ensure better and more adequate representation across ethnicities and low- and middle-income countries and communities.

Joint first author Clare Rogowski, also from the MRC Epidemiology Unit, said: “Efforts to reduce exposure to these key pollutants are likely to help reduce the burden of dementia on society. Stricter limits for several pollutants are likely to be necessary targeting major contributors such as the transport and industry sectors. Given the extent of air pollution, there is an urgent need for regional, national, and international policy interventions to combat air pollution equitably.”

Further analysis revealed that while exposure to these pollutants increased the risk of Alzheimer’s disease, the effect seemed stronger for vascular dementia, a type of dementia caused by reduced blood flow to the brain. Around 180,000 people in the UK are thought to be affected by this type of dementia. However, as there were only a small number of studies that examined this difference, the researchers did not class it as statistically significant.

Joint first author Dr Christiaan Bredell from the University of Cambridge and North West Anglia NHS Foundation Trust said: “These findings underscore the need for an interdisciplinary approach to dementia prevention. Preventing dementia is not just the responsibility of healthcare: this study strengthens the case that urban planning, transport policy, and environmental regulation all have a significant role to play.”

The research was funded by the European Research Council under the Horizon 2020 research and innovation programme and from the European Union’s Horizon Europe Framework Programme.

Reference

Best Rogowski, CB, & Bredell, C et al. Long-term Air Pollution Exposure and Incident Dementia: A Systematic Review and Meta-Analysis. Lancet Planetary Health; 24 July 2025; DOI: 10.1016/S2542-5196(25)00118-4



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New Chancellor elected at the University of Cambridge

Lord Chris Smith.

Lord Chris Smith has been elected as the new Chancellor of the University of Cambridge.

To be elected as Chancellor of the University I love is a huge honour. I’m thrilled. I look forward to being the best possible ambassador for Cambridge, to being a strong voice for higher education more generally, and to working closely together with the Vice-Chancellor and her team.Lord Smith

Lord Smith, the outgoing Master of Pembroke College, Cambridge, becomes the 109th Chancellor and will hold the office for ten years.

He said: “To be elected as Chancellor of the University I love is a huge honour. I’m thrilled. I look forward to being the best possible ambassador for Cambridge, to being a strong voice for higher education more generally, and to working closely together with the Vice-Chancellor and her team.”

Lord Smith’s election follows a process which attracted ten candidates. For the first time the election was opened to online voting and more than 23,000 alumni and staff participated. In addition, almost 2,000 chose to vote in person at the University’s Senate House.

Professor Deborah Prentice, the Vice-Chancellor, said: “On behalf of everyone at the University, I offer my warm congratulations to Chris on his election. I very much look forward to working with him and building on the strong relationship that we have developed since I became Vice-Chancellor. Chris has had a long involvement with the University and brings a wealth of relevant experience to this important role.”

“I would like to thank the other nine candidates for standing for the role and their willingness to serve Cambridge.”

Lord Smith has been the Master of Pembroke since 2015 and steps down at the end of July. He is a former Secretary of State for Culture, Media and Sport, and later Chairman of the Environment Agency.

Born in 1951, Lord Smith was educated in Edinburgh and then Pembroke College, Cambridge, achieving a double first in English (and later a PhD on Wordsworth and Coleridge) and was also a Kennedy Scholar at Harvard.

He began his political career as a Labour Councillor for the London Borough of Islington, becoming MP for Islington South and Finsbury in 1983. In 1992 he joined the Shadow Cabinet and held a number of front bench posts before Labour came to power in 1997. He served as Secretary of State for Culture, Media and Sport until 2001 when he returned to the back benches, standing down from the Commons in 2005.  Immediately afterwards he was made a life peer.

In July 2008 he became Chairman of the Environment Agency. He chaired the Environment Agency from 2008 to 2014; from 2007 to 2017 he was also Chairman of the Advertising Standards Authority.

The position of Chancellor stretches back more than 800 years to the foundation of the University. Although the role is primarily ceremonial and without executive responsibilities, the Chancellor has an important part to play in acting as a sounding board for senior figures within the University, in supporting fundraising and in acting as an ambassador for Cambridge. The most significant commitment for the Chancellor is to advocate and support the University’s aims and strategic interests.

The election was held between 9 and 18 July. It was conducted under the single transferable vote system and administered on behalf of the University by Civica Election Services. The results, based on the final numbers of votes allocated to each candidate, were as follows:  

  1. Chris Smith, Baron Smith of Finsbury
  2. Dr Mohamed El-Erian
  3. Ms Sandi Toksvig
  4. John Browne, Baron Browne of Madingley
  5. Professor Wyn Evans
  6. Mrs Gina Miller
  7. Mr Tony Booth
  8. Dr Mark Mann
  9. Dr Ayham Ammora
  10. Mr Ali Azeem

Read the full results



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Clearing rainforest for cattle farming is far worse for nature than previously thought, finds landmark bird survey

Savanna hawk is a widespread species that invades formerly forested areas after clearance
Savanna hawk is a widespread species that invades formerly forested areas after clearance
Credit: David Edwards

In the largest ever survey of rainforest birdlife, scientists have discovered that deforestation to create pastureland in Colombia is causing around 60% more damage to biodiversity than previously estimated.

The food we eat comes with a much great environmental cost than we thought. We need policy makers to think much more about the larger scale biodiversity impact of deforestation.David Edwards

Researchers have conducted the world’s biggest ever bird survey, recording 971 different species living in forests and cattle pastures across the South American country of Colombia. This represents almost 10% of the world’s birds.

They combined the results, gathered over a decade, with information on each species’ sensitivity to habitat conversion to find that the biodiversity loss caused by clearing rainforest for cattle pasture is on average 60% worse than previously thought.

Until now, understanding the biodiversity impact of land-use change has generally involved small-scale, local surveys. The researchers say that this approach does not represent the larger-scale damage caused to nature.

When forests are converted to pasture, some species win and others lose. Measuring the biodiversity loss at local scale does not capture the larger-scale effect of forest conversion, which is occurring across the ranges of many different species. While the same species usually survive on pastureland, a wide range of other species don’t, so overall biodiversity is more severely reduced at large scale.

The results are published today in the journal Nature Ecology and Evolution.

Professor David Edwards in the University of Cambridge’s Department of Plant Sciences and Conservation Research Institute, senior author of the report, said: “This is a really surprising result. We found that the biodiversity loss caused by clearing rainforest for pastureland is being massively underestimated.”

He added: “When people want to understand the wider impact of deforestation on biodiversity, they tend to do a local survey and extrapolate the results. But the problem is that tree clearance is occurring at massive spatial scales, across all sorts of different habitats and elevations.

“When we looked the biodiversity impact of deforestation across thirteen different eco-regions in Colombia, we found a 62% greater biodiversity loss than local survey results would indicate.”

The study also showed that at least six different eco-regions – that is, regions containing distinct types of plants and animals – must be considered for an accurate assessment of overall biodiversity impact. This is because the species in different eco-regions have different sensitivities to habitat conversion.

Biodiversity offsetting schemes, which aim to compensate for species losses caused by developments in one place by boosting biodiversity in another, rely on accurate measures of biodiversity.

Trees are also being cleared at huge scales in Colombia and other tropical regions to create growing space for major agricultural crops including rubber, oil palm, sugar cane and coffee.

Edwards said: “The food we eat comes with a much great environmental cost than we thought. We need policy makers to think much more about the larger scale biodiversity impact of deforestation.”

Tropical birdsong recordings

The team studied Columbia’s birdlife across its diverse landscapes for over seven years, recording the song of hundreds of bird species to help them identify the species present in landscapes across the country, from pasture to mountain forest. In about 80% of cases the birds were heard but not seen, requiring the team to make identifications from the sounds alone.

With information about the birds, including their size and diet, the team could predict which other species were likely to be living in the same regions and how they too would respond to deforestation.

A highly biodiverse country

Colombia is home to some of the most beautiful and exotic animal and plant life in the world, with almost one third made up of rainforest.

Particularly biodiverse areas, including the Caqueta moist forests and the Napo moist forests, can have 500-600 different bird species within an area of ten square kilometres – but many of these species have very specific habitat requirements. The study showed that if trees are cleared across their range these species are likely to die out.

Land-use change, particularly in the highly biodiverse tropics, is one of the main causes of the global biodiversity crisis.

This research was funded by the Research Council of Norway and the Natural Environment Research Council.

Reference

Socolar, J B et al: ‘Tropical biodiversity loss from land-use change is severely underestimated by local-scale assessments.’ Nature Ecology and Evolution, July 2025. DOI: 10.1038/s41559-025-02779-4



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Researchers use AI to ‘see’ landslides and target disaster response

Rescue teams at one of the landslides following the Taiwan earthquake
Rescue teams at one of the landslides following the Taiwan earthquake
Credit: Taitung County Government via Wikimedia Commons

Researchers from the University of Cambridge are using AI to speed up landslide detection following major earthquakes and extreme rainfall events—buying valuable time to coordinate relief efforts and reduce humanitarian impacts.

On 3 April 2024, a magnitude 7.4 quake—Taiwan’s strongest in 25 years—shook the country’s eastern coast. Stringent building codes spared most structures, but mountainous and remote villages were devastated by landslides.

When disasters affect large and inaccessible areas, responders often turn to satellite images to pinpoint affected areas and prioritise relief efforts.

But mapping landslides from satellite imagery by eye can be time-intensive, said Lorenzo Nava, who is jointly based at Cambridge’s Departments of Earth Sciences and Geography. “In the aftermath of a disaster, time really matters,” he said. Using AI, he identified 7,000 landslides after the Taiwan earthquake, and within three hours of the satellite imagery being acquired.

Since the Taiwan earthquake, Nava has been developing his AI method alongside an international team. By employing a suite of satellite technologies—including satellites that can see through clouds and at night—the researchers hope to enhance AI’s landslide detection capabilities.

Multiplying hazards

Triggered by major earthquakes or intense rainfall, landslides are often worsened by human activities such as deforestation and construction on unstable slopes. In certain environments, they can trigger additional hazards such as fast-moving debris flows or severe flooding, compounding their destructive impact.

Nava’s work fits into a larger effort at Cambridge to understand how landslides and other hazards can set off cascading ‘multihazard’ chains. The CoMHaz group, led by Maximillian Van Wyk de Vries, Professor of Natural Hazards in the Departments of Geography and Earth Sciences, draws on information from satellite imagery, computer modelling and fieldwork to locate landslides, understand why they happen and ultimately predict their occurrence.

They’re also working with communities to raise landslide awareness. In Nepal, Nava and Van Wyk de Vries teamed up with local scientists and the Climate and Disaster Resilience in Nepal (CDRIN) consortium to pilot an early warning system for Butwal, which sits beneath a massive unstable slope.

Improved AI-detection

Nava is training AI to identify landslides in two types of satellite images—optical images of the ground surface and radar data, the latter of which can penetrate cloud cover and even acquire images at night.

Radar images can, however, be difficult to interpret, as they use greyscale to depict contrasting surface properties and landscape features can also appear distorted. These challenges make radar data well-suited for AI-assisted analysis, helping extract features that may otherwise go unnoticed.

By combining the cloud-penetrating capabilities of radar with the fidelity of optical images, Nava hopes to build an AI-powered model that can accurately spot landslides even in poor weather conditions.

His trial following the 2024 Taiwan earthquake showed promise, detecting thousands of landslides that would otherwise go unnoticed beneath cloud cover. But Nava acknowledges that there is still more work needed, both to improve the model’s accuracy and its transparency.

He wants to build trust in the model and ensure its outputs are interpretable and actionable by decision-makers. “Very often, the decision-makers are not the ones who developed the algorithm,” said Nava. “AI can feel like a black box. Its internal logic is not always transparent, and that can make people hesitant to act on its outputs.

“It’s important to make it easier for end users to evaluate the quality of AI-generated information before incorporating it into important decisions.” 

This is something he is now addressing as part of a broader partnership with the European Space Agency (ESA), the World Meteorological Organization (WMO), the International Telecommunication Union’s AI for Good Foundation and Global Initiative on Resilience to Natural Hazards through AI Solutions.

At a recent working group meeting at the ESA Centre for Earth Observation in Italy, the researchers launched a data-science challenge to crowdsource efforts to improve the model. “We’re opening this up and looking for help from the wider coding community,” said Nava.

Beyond improving the model’s functionality, Nava says the goal is to incorporate features that explain its reasoning—potentially using visualisations such as maps that show the likelihood of an image containing landslides to help end users understand the outputs.

“In high-stakes scenarios like disaster response, trust in AI-generated results is crucial. Through this challenge, we aim to bring transparency to the model’s decision-making process, empowering decision-makers on the ground to act with confidence and speed.”

Reference: 
Lorenzo Nava, Alessandro Novellino et al. ‘Brief Communication: AI-driven rapid landslides mapping following the 2024 Hualien City Earthquake in Taiwan.’ Natural Hazards and Earth System Sciences (2025). DOI: 10.5194/nhess-25-2371-2025



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How will AI change the way we conduct scientific research?

By Sarah Collins

Abstract AI concept with an illustration of a human head on a circuit board

How might AI change the way we advance human knowledge? Could it change how universities like Cambridge carry out one of their core functions: research? Could AI be a technological transformation unlike anything we’ve seen before?

A group of Cambridge researchers say that the answer to the last two questions is yes. But this is not because of some mysterious breakthrough or wishful thinking, but the relentless march of computational power. “What’s changed isn’t the methods – we’ve had most of those since the 1970s,” said Dr James Fergusson from Cambridge’s Department of Applied Mathematics and Theoretical Physics (DAMTP). “What’s changed is that we now have enough computing power and data to make them work.”

If Moore’s Law holds – as it has for the past 50 years – computing power will keep growing by a factor of 30 every decade. Even without smarter algorithms, hardware power alone will drive AI systems to become exponentially more capable and more embedded in our lives in the coming years.

“Most of the AI tools in widespread use today are essentially mimicking things humans already do, but just doing them faster,” said Fergusson. “We want to really push the maths of AI, so we can get it to do new things. We don’t want it to mimic data, but to tell you how it works and break it down. That’s where the real change will happen.”

Dr James Fergusson

In addition to his role in DAMTP, Fergusson is Director of the Infosys-Cambridge AI Centre, which was opened in the autumn of 2024 at Infosys’ London premises in Canary Wharf. The AI Lab is part of a wider University partnership with the multinational technology and consulting company, meant to make Cambridge’s cutting-edge AI research accessible to industry.

“In the past, companies have found it hard to navigate Cambridge,” said Fergusson. “We want to create a gateway: somewhere businesses can come to ask their questions, and find out what AI can really do for them, and we can learn what challenges they face. We hope this partnership with Infosys is a model of how that could be done.”

There are three main research themes in the AI Centre:

  • AI-enhanced simulations for improving our understanding of physical systems, which will help AI ‘think’ like scientists, including initiatives such as the Polymathic AI project
  • Mathematical AI, or theoretical physics for AI, which will look at how we take ideas from theoretical physics and use them to understand how neural networks work and how they learn; and how we extract knowledge from machine learning systems
  • Agentic AI systems, a way of automating much of the process of scientific research, such as processing data, building software and writing things up.

Dr Boris Bolliet from Cambridge’s Cavendish Laboratory and Agentic AI Research Lead at the Infosys-Cambridge AI Centre is developing these custom multi-agent systems, based on large language models (LLMs) such as ChatGPT, Claude and Gemini. Bolliet and his team use multi-agent systems, such as CMBAgent and DENARIO, to plan and execute complex tasks, from financial simulations and cosmological data analysis, to autonomous research and paper writing.

“I believe that a lot of things are going to change in the way we do research,” said Bolliet, whose research background is in cosmology and computational astrophysics. “Maybe that means that a lot of repetitive, time-consuming tasks that I spend a lot of my energy on will soon be automated, giving me more time and space to do more interesting things.”

Dr Boris Bolliet

Multi-agent systems work by breaking complex problems into smaller tasks, verify their own outputs, and work like digital research assistants. They are more robust than single AI models because they can plan, review, and cross-check their own work.

The multi-agent model allows Bolliet to assign a role or even a ‘personality’ to each agent. For example, one agent could be a researcher and one an engineer, or one could be an idea generator and one could be a ‘hater’, relentlessly challenging and criticising to make the end product more robust.

Bolliet says that using these multi-agent systems, AI will not only be able to generate research but can also review and correct scientific literature at scale. And unlike humans, it will be able to seamlessly jump across academic fields, from astronomy to oncology, to find the best solutions.

“We want to use AI to accelerate the exchange of information across fields,” said Bolliet. “AI agents don’t have these barriers. They’re not stuck in one discipline like we human researchers are.”

Bolliet says that while we often think of LLMs as black boxes prone to hallucinations, using the multi-agent model allows him to check every step of the research process. “I can see every single step that has occurred and go through the code line by line,” he said. “I can reproduce the research entirely, which is not necessarily true when you talk to your colleagues and ask them what they did in their paper.”

Using tools such as multi-agent systems, the coming AI revolution is poised to replace many tasks that require human intelligence – everything from legal drafting to scientific research. For many people, this raises a worrying question: if machines can do our jobs, what’s left for us to do?

The answer, Fergusson says, is surprisingly hopeful. As AI systems increasingly take over routine and specialised tasks – writing code, analysing data, automating customer service – the most valuable commodity becomes something machines can’t yet replicate: original ideas.

“To paraphrase Edison, AI might handle 99% of the perspiration, but it still takes a human for that 1% of inspiration,” he said. “This shift could unlock extraordinary potential.”

For example, a student who has a great idea for an app who doesn’t know how to code can now describe their idea to an AI, and it will write the code, test it, and launch it. As implementation becomes easier, the emphasis will move from skills to creativity. The future, Fergusson says, will belong to those who can ask the best questions.

“There is a transformational opportunity to change the way scientific research is done using AI,” he said.  “It will no longer be something only humans can do, but as something we do in collaboration with machines, that can carry out high-level scientific analysis, fast and accurately.”

The research happening at the AI Centre is also relevant to Infosys and its clients because, ultimately, the problems they are trying to solve are the same. How do we harness the enormous volumes of data at our fingertips into real knowledge?

“Many of Infosys’ clients want to have explainability,” said Fergusson. “They want to have simulations that can run faster and can be trusted. They want to use the power of multi-agent systems to automate business processes for knowledge processing tasks. Infosys is the connector between the centre and the business world, so this knowledge can be shared globally across all sectors.

“The universality of the challenge of AI is bringing science and industry together – we all face the same challenges in adopting it and using it for our work.”

Of course, AI is far from perfect. The amount of water and energy used by the data centres powering most AI technology is gigantic, and risks derailing the progress humans are making towards achieving net zero.

And language models still make things up, or forget their own logic in longer responses. They’re more convincing than correct. But Fergusson says these flaws can be managed – especially with agent-based systems that check each other’s work and bring in outside data sources.

He also warns against viewing AI as purely hype or purely harmful. “Most people’s experience of AI is a chatbot that’s trying and failing to get you to buy a washing machine,” said Fergusson. “But under the surface, it’s changing everything, from scientific discovery to creative industries.”


Published 21 July 2025


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Cambridge and DSIT announce prestigious Spärck AI Scholarships to support next generation of AI leaders

University of Cambridge students walking into the Senate House for their graduation ceremony.
University of Cambridge students walking into the Senate House for their graduation ceremony.
Credit: University of Cambridge

The Department for Science, Innovation and Technology (DSIT) has today announced the launch of the Spärck AI Scholarships, a major new initiative to nurture the next generation of AI leaders, with Cambridge University proud to join as a founding partner.

We are delighted to be a founding partner in this ambitious initiative, which reflects a shared commitment to attracting exceptional talent and reinforcing the UK’s position as a home for world-class AI.Professor Deborah Prentice, University of Cambridge Vice-Chancellor,

The scholarships, aimed at exceptionally high-potential domestic and international students, will support study towards AI-related Masters degrees and provide an unparalleled package of benefits. Students will receive full tuition fees, a living stipend, and access to priority work placements with leading UK AI companies and government institutions.

The programme, which will open to its first cohort in the 2026/27 academic year, intends to enrol 100 scholars over its first four years. Scholars will be selected from the top 1% of AI talent worldwide, with applicants required to demonstrate academic excellence, leadership, and ambassadorial potential, alongside a STEM background.

Uniquely, the Spärck AI Scholarships will provide its students with priority access to work placements within UK-based AI companies and organisations, including the UK government’s AI Security Institute (AISI) and i.AI, their in-house AI incubator.

The scholarships are named in honour of Professor Karen Spärck Jones (1935–2007), a pioneering British computer scientist whose ground breaking work at Cambridge University laid the foundations for modern search engines and natural language processing. One of the most remarkable women in computer science, her seminal 1972 paper introduced the concept of inverse document frequency (IDF), a fundamental principle still central to information retrieval today.

Professor Deborah Prentice, University of Cambridge Vice-Chancellor, said: “Cambridge combines academic excellence with a dynamic, interdisciplinary AI community, from foundational research to real-world impact. We are delighted to be a founding partner in this ambitious initiative, which reflects a shared commitment to attracting exceptional talent and reinforcing the UK’s position as a home for world-class AI. We are especially proud that these scholarships are named after Karen Spärck Jones, a brilliant Cambridge computer scientist.”

A long-time valued member of the Cambridge community, Professor Spärck Jones was an undergraduate at Girton College (1953-1956), a Research Fellow at Newnham College (1965-1968), an Official Fellow of Darwin College (1968-1980) and a Fellow of Wolfson College (2000-2007).

She began her research career at the Cambridge Language Research Unit in the late 1950s and later taught for the MPhil in Computer Speech and Language Processing, on language systems, and for the Computer Science Tripos on information retrieval. She supervised many Cambridge PhD students across a wide range of topics and was a tireless advocate for women in computing, famously declaring: “I think it’s very important to get more women into computing. My slogan is: Computing is too important to be left to men.”

Her international influence was recognised by numerous awards, including the ACM SIGIR Salton Award, the BCS Lovelace Medal, and election as a Fellow of the British Academy (of which she was also Vice-President from 2000 to 2002) and the American Association for Artificial Intelligence.

The University of Cambridge is delighted to honour her legacy by co-founding this exciting new programme, which was formally announced today at London Tech Week.



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Cambridge and Manchester partnership to boost UK innovation and growth gets government backing

Cambridge will join forces with Manchester as part of a pioneering collaboration to harness the combined strengths of both universities and cities – and boost innovation and growth for the whole of the UK

This pioneering initiative brings together the combined strengths of Cambridge and Manchester to create something that is truly groundbreaking.Professor Deborah Prentice, Vice-Chancellor

The Cambridge x Manchester Innovation Partnership – the first trans-UK innovation collaboration of its kind – will receive £4.8m of funding from Research England over three years, it has been announced. With further investment from the two universities, the total funding for the partnership will be £6m. The initiative aims to strengthen research networks, accelerate scale-up growth, drive private sector investment into R&D, and attract new foreign direct investment.

Led by the universities of Cambridge and Manchester, ‘CBG×MCR’ is supported by two mayoral combined authorities, city councils, key businesses (such as AZ, ARM, ROKU, and Microsoft), venture capitalists (Northern Gritstone and CIC), and angel investors (Cambridge and Manchester Angels).

As well as strengthening relations within and between the two cities, the partnership – fronted by Innovate Cambridge and Unit M – will pilot new approaches for delivering inclusive growth, providing insights to other cities, the wider higher education sector community, and local and national governments in the UK and internationally.

In the UK, collaboration has traditionally been focused on geographically proximate areas, such as Manchester-Liverpool, or Edinburgh-Glasgow. This new model of hyper-connected, place-to-place partnering – similar to those developed in the US’ Northeast Corridor, Coastal California, and China’s Greater Bay Area – combines complementary innovation capabilities to create globally competitive connected ecosystems.

Amplifying what each city can achieve independently, the model aims to drive national economic growth, responding directly to the UK government’s national industrial strategy.

Professor Deborah Prentice, Vice-Chancellor of the University of Cambridge, said: “This pioneering initiative brings together the combined strengths of Cambridge and Manchester to create something that is truly groundbreaking. By connecting our cities, we’re helping to build a more collaborative and dynamic environment in which innovative research can connect with industry, venture capital, and entrepreneurs, to drive economic growth and deliver real benefits for people and places across the UK.”

Paul Bristow, Mayor of Cambridgeshire and Peterborough, said: “This is exactly the kind of partnership working we need to fire up innovation-led growth in both our regions. I’m delighted to see it backed with new funding. By joining forces to drive the discoveries of tomorrow, we can bring in investment, support exciting new businesses, and deliver real jobs and opportunity for our communities.”

Professor Duncan Ivison, President and Vice-Chancellor at the University of Manchester, said: “Our partnership with Cambridge marks a new model of collaboration between UK universities. It brings together the distinctive strengths of each of our universities and cities, connecting two of the great innovation ecosystems to scale up what we can achieve. This new approach to innovation accelerates the time between discovery and impact, getting ideas into the real economy and our communities even more quickly to drive inclusive growth.”

Jessica Corner, Executive Chair of Research England, said: “This investment underscores our commitment to fostering innovation and collaboration across England. By connecting the vibrant ecosystems of Cambridge and Manchester, we aim to drive significant economic growth and create a model for place-based innovation that can be replicated nationwide.”



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Whistleblowing tech based on Cambridge research launched by the Guardian

Illustration of a whistleblower in crowd
Illustration of a whistleblower in crowd
Credit: Nanzeeba Ibnat via Getty Images

Whistleblowers can contact journalists more securely thanks to a new confidential and anonymous messaging technology co-developed by University of Cambridge researchers and software engineers at the Guardian.

The Guardian has launched Secure Messaging as a module within its mobile news app to provide a secure and usable method of establishing initial contact between journalists and sources.

It builds on a technology – CoverDrop –developed by Cambridge researchers and includes a wide range of security features. The code is available online and is open source, to encourage adoption by other news organisations.

The app automatically generates regular decoy messages to the Guardian to create ‘air cover’ for genuine messages, even when they are passing through the cloud, preventing an adversary from finding out if any communication between a whistleblower and a journalist is taking place.

“This provides whistleblowers with plausible deniability,” said Professor Alastair Beresford from Cambridge’s Department of Computer Science and Technology.

“That’s important in a world of pervasive surveillance where it has become increasingly hazardous to be a whistleblower,” said Cambridge’s Dr Daniel Hugenroth, who co-led the development of CoverDrop with Beresford.

The technology also provides digital ‘dead drops’ – like virtual bins or park benches – where messages are left for journalists to retrieve. These are just two of a suite of functions that protect a source from discovery even if their smartphone is seized or stolen.

CoverDrop encrypts outgoing messages between the source and their named contact at the news organisation to ensure no other party can read their content. For this, it relies on cryptography using digital security key pairs consisting of a public and a secret key.

The source is given the public key that instructs the existing encryption technology on their smartphone to encrypt their messages to the Guardian. This key only works one way, so it can lock – but not unlock – their messages. The only person able to decode them is the whistleblower’s named contact at the Guardian, who uses their secret key to retrieve and decode the messages left in the dead drop.

CoverDrop also pads all messages to the same length, making it harder for adversaries – whether acting on their own behalf or for an organisation or state – to distinguish real messages from decoy ones. 

The system fulfils a need long identified by media organisations: providing a highly secure, yet easy-to-use, system for potential sources who want to contact them with sensitive information.

“The Guardian is committed to public-interest journalism,” said Luke Hoyland, product manager for investigations and reporting at The Guardian. “Much of this is possible thanks to first-hand accounts from witnesses to wrongdoing. We believe whistleblowing is an important part of a functioning democracy and will always do our utmost to avoid putting sources at risk. So we’re delighted to have worked with the University of Cambridge on turning their groundbreaking CoverDrop research into a reality.”

The research began with workshops with UK news organisations to find out how potential sources first contacted them. The researchers learned that whistleblowers often reach out to them via platforms that are either insecure or hard to use.

Beresford said that when they started looking for a practical solution to this problem, “we realised that news organisations already run a widely available platform from which they can offer a secure, usable method of initial contact – their mobile news app.”

“When sources send messages, their confidentiality and integrity can be assured through the secure messaging protocols on their smartphone,” said Hugenroth. “CoverDrop goes one step further and also protects the communication patterns between sources and journalists by using decoy messages to provide cover and padding all messages to the same length.”

Importantly, the researchers say, users of the new CoverDrop system won’t need to install any specialist software that chews up large amounts of battery power or slows down their phones.

Its simple interface looks and works just like a typical messaging app. And there are no traces left on the device that the CoverDrop system has ever been used on that phone before.

“When you open the app,” said Beresford, “even if you’ve already set up an account on it, the CoverDrop feature will look as though you haven’t used it. Its home screen will only offer two prompts – ‘Get started’ or ‘Check your message vault’. This is because if it’s stolen, or a user is under duress, we don’t want your phone to reveal to anyone that you’ve already used it.”

The development of CoverDrop began in the years after the whistleblower Edward Snowden, a former US intelligence contractor, leaked classified documents revealing the existence of global surveillance programmes.

This showed, the researchers said, the mass surveillance infrastructure available to nation states, which has profound implications for those who wish to expose wrongdoing within companies, organisations, and government.

Work on CoverDrop was first unveiled at an international Symposium on Privacy-Enhancing Technologies in 2022 by the Cambridge researchers (who originally included the late Professor Ross Anderson, a leader in security engineering and privacy).

When they published their peer-reviewed paper on the research at the conference, it attracted interest from the Guardian which, in collaboration with the researchers, subsequently helped develop CoverDrop from an academic prototype into a fully usable technology.

“The free press fulfils an important function in a democracy,” said Beresford. “It can provide individuals with a mechanism through which they can hold powerful people and organisations to account. We’re delighted that the Guardian is the first media organisation to adopt CoverDrop and will use it to help protect their sources.”

“All the CoverDrop code will be available online and open source,” said Hugenroth. “This transparency is essential for security-critical software and allows others to audit and improve it. Open-sourcing the code also means that other news organisations, particularly those with expertise in investigative journalism, could also use it. We would be excited to see them do so.”

References:
Mansoor Ahmed-Rengers et al. ‘CoverDrop: Blowing the Whistle Through A News App.’ Paper presented at the Privacy Enhancing Technologies Symposium. 12 July 2022, Sydney, Australia. DOI: 10.2478/popets-2022-0035

A new technical report on CoverDrop, describing its architecture and explaining how it works, is available at: www.coverdrop.org/coverdrop_guardian_implementation_june_2025.pdf



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Cambridge researcher awarded the Shaw Prize in Astronomy

John Richard Bond (left) and George Efstathiou (right)
John Richard Bond (left) and George Efstathiou (right)
Credit: Shaw Prize

Professor George Efstathiou has been awarded the Shaw Prize in Astronomy, one of the biggest prizes in the field.

Efstathiou, Emeritus Professor of Astrophysics (1909) at Cambridge’s Institute of Astronomy, shares the prize with Professor John Richard Bond from the Canadian Institute for Theoretical Astrophysics and the University of Toronto.

They were recognised for their pioneering research in cosmology, in particular for their studies of fluctuations in the cosmic microwave background. Their predictions have been verified by an armada of ground-, balloon- and space-based instruments, leading to precise determinations of the age, geometry, and mass-energy content of the universe.

Cosmology has undergone a revolution in the past two decades, driven mainly by increasingly precise measurements of the angular power spectrum of fluctuations in the temperature and polarisation fields of the cosmic microwave background, a relic of the early universe, most notably by NASA’s Wilkinson Microwave Anisotropy Probe spacecraft (2001–2010) and the European Space Agency’s Planck spacecraft (2009–2013).

These fluctuations are small — the strength of the background radiation is the same in all directions to better than 0.01% and it is only slightly polarised — but they offer a glimpse of the universe when it was very young, a test of many aspects of fundamental physics, insights into the nature of dark matter and dark energy, and measurements of many fundamental cosmological parameters with accuracies unimaginable to cosmologists a few decades ago.

Although many researchers contributed to the development of the theoretical framework that governs the behaviour of the cosmic microwave background, Bond and Efstathiou emphasised the importance of the background as a cosmological probe and took the crucial step of making precise predictions for what can be learned from specific models of the history and the composition of the mass and energy in the universe.

Modern numerical codes used to interpret the experimental results are based almost entirely on the physics developed by Bond and Efstathiou. Their work exemplifies one of the rare cases in astrophysics where later experimental studies accurately confirmed unambiguous, powerful theoretical predictions.

The interpretation of these experiments through Bond and Efstathiou’s theoretical models shows that the spatial geometry of the observable universe is nearly flat, and yields the age of the universe with a precision of 0.15%, the rate of expansion of the universe with a precision of 0.5%, the fraction of the critical density arising from dark energy to better than 1%, and so on. The measurements also strongly constrain theories of the early universe that might have provided the initial “seed” for all the cosmic structure we see today, and the nature of the dark matter and dark energy that dominate the mass-energy content of the universe.

Both Bond and Efstathiou have worked closely with experimentalists to bring their predictions to the test: they have been heavily involved in the analysis of cosmic microwave background data arising from a wide variety of experiments of growing sophistication and accuracy.

George Efstathiou received his BA in Physics from the University of Oxford and PhD in Astronomy from Durham University. He has held postdoctoral fellowships at the University of California, Berkeley, USA and the University of Cambridge. He was Savilian Professor of Astrophysics at Oxford, where he served as Head of Astrophysics until 1994. He returned to Cambridge in 1997 as Professor of Astrophysics, where he also served as Director of the Institute of Astronomy and the first Director of the Kavli Institute for Cosmology. He received the 2022 Gold Medal of the Royal Astronomical Society. He is a Fellow of the Royal Society of London and the Royal Astronomical Society, UK. He is a Fellow of King’s College, Cambridge.

Originally published on the Shaw Prize website. 



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Cambridge celebrates historic Varsity Athletics competition and World Athletics recognition

The world’s oldest athletics competition — the annual contest between Cambridge and Oxford — reached a landmark celebration this year, commemorating 150 years of men’s competition, 50 years of women’s competition, and the second year of the para-athletics Varsity. 

First held in 1864, Varsity Athletics remains an enduring symbol of sporting excellence and tradition. This year’s event, hosted at Wilberforce Road Sports Ground in Cambridge, was made even more special by a prestigious recognition from World Athletics: the awarding of two Heritage Plaques to Cambridge University Athletic Club (CUAC) and the Varsity Match itself.

World Athletics Heritage Plaque

Founded in 1857, CUAC is one of the oldest athletics clubs in the world. It played a pivotal role in the development of modern athletics, contributing to the rules and formats that govern the sport today. “Cambridge University Athletic Club is among a small group of pioneering organisations that helped shape modern athletics,” World Athletics noted in its announcement.

In honour of this distinguished history, World Athletics CEO and Cambridge alumnus Jon Ridgeon (Magdalene College) returned to his alma mater to present the plaques during the Varsity weekend. 

Athletics Varsity 2025

Living up to the historic occasion, fierce but friendly rivalry was on display, with Cambridge securing victories in:

  • Men’s Blues
  • Para Team
  • Men’s 2nds
  • Women’s 2nds

In an interview with Varsity newspaper ahead of the Athletics Varsity, CUAC President Jess Poon reflected on the club’s evolution and the importance of the Varsity Matches. She highlighted the club’s embrace of inclusivity, particularly with the expansion of women’s and para-athletics matches, and celebrated the sense of tradition and camaraderie that continues to define the event.

Athletics Varsity plaque giving

This milestone celebration aligns closely with the University’s priority to encourage participation in sport and physical activity at all levels. Sport plays a critical role in supporting mental wellbeing, fostering leadership and communication skills, and enhancing employability among students.

Across the University, activity priorities include:

  • Club Support Programme: Aimed at helping sports clubs like CUAC deliver high-quality training and competition experiences, ensuring sustainability and growth.
  • University of Cambridge Athlete Performance Programme (UCAPP): Providing specialist support for high-performing athletes, enabling them to excel both in their sport and academically.
  • Active Students Initiative: Promoting sport and physical activity for all students, regardless of ability or experience level, through programmes like ‘Give it a Go’, designed to remove barriers and encourage lifelong engagement with physical activity.

Bhaskar Vira, Pro-Vice-Chancellor for Education and Chair of the Sports Committee, has expressed the University’s enthusiasm for supporting sport: “Involvement in physical activity and sports provides a much-needed release from the intense pressures that are associated with life at Cambridge. I firmly believe that these are inherently complementary pursuits, allowing participants to achieve a balance between their work commitments and their own personal wellbeing.”

The 150th Men’s, 50th Women’s, and 2nd Para Athletics Varsity Matches not only celebrated a rich and trailblazing past but also pointed towards a vibrant future, powered by a University-wide commitment to excellence, inclusion, and wellbeing in sport.

As Cambridge looks to build on this legacy, the University invites alumni and supporters to help sustain and grow these opportunities – ensuring that generations of Cambridge students continue to benefit from the profound personal, academic, and societal advantages that sport and physical activity bring.

Find out more information on how to support sport at Cambridge.

Varsity Athletics team



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‘AI scientist’ suggests combinations of widely available non-cancer drugs can kill cancer cells

Scanning electron microscope image of breast cancer cells
Scanning electron microscope image of breast cancer cells
Credit: STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY via Getty Images

An ‘AI scientist’, working in collaboration with human scientists, has found that combinations of cheap and safe drugs – used to treat conditions such as high cholesterol and alcohol dependence – could also be effective at treating cancer, a promising new approach to drug discovery.

The research team, led by the University of Cambridge, used the GPT-4 large language model (LLM) to identify hidden patterns buried in the mountains of scientific literature to identify potential new cancer drugs.

To test their approach, the researchers prompted GPT-4 to identify potential new drug combinations that could have a significant impact on a breast cancer cell line commonly used in medical research. They instructed it to avoid standard cancer drugs, identify drugs that would attack cancer cells while not harming healthy cells, and prioritise drugs that were affordable and approved by regulators.

The drug combinations suggested by GPT-4 were then tested by human scientists, both in combination and individually, to measure their effectiveness against breast cancer cells.

In the first lab-based test, three of the 12 drug combinations suggested by GPT-4 worked better than current breast cancer drugs. The LLM then learned from these tests and suggested a further four combinations, three of which also showed promising results.

The results, reported in the Journal of the Royal Society Interface, represent the first instance of a closed-loop system where experimental results guided an LLM, and LLM outputs – interpreted by human scientists – guided further experiments. The researchers say that tools such as LLMs are not a replacement for scientists, but could instead be supervised AI researchers, with the ability to originate, adapt and accelerate discovery in areas like cancer research.

Often, LLMs such as GPT-4 return results that aren’t true, known as hallucinations. However, in scientific research, hallucinations can sometimes be beneficial if they lead to new ideas that are worth testing.

“Supervised LLMs offer a scalable, imaginative layer of scientific exploration, and can help us as human scientists explore new paths that we hadn’t thought of before,” said Professor Ross King from Cambridge’s Department of Chemical Engineering and Biotechnology, who led the research. “This can be useful in areas such as drug discovery, where there are many thousands of compounds to search through.”

Based on the prompts provided by the human scientists, GPT-4 selected drugs based on the interplay between biological reasoning and hidden patterns in the scientific literature.

“This is not automation replacing scientists, but a new kind of collaboration,” said co-author Dr Hector Zenil from King’s College London. “Guided by expert prompts and experimental feedback, the AI functioned like a tireless research partner—rapidly navigating an immense hypothesis space and proposing ideas that would take humans alone far longer to reach.”

The hallucinations – normally viewed as flaws – became a feature, generating unconventional combinations worth testing and validating in the lab. The human scientists inspected the mechanistic reasons the LLM found to suggest these combinations in the first place, feeding the system back and forth in multiple iterations.

By exploring subtle synergies and overlooked pathways, GPT-4 helped identify six promising drug pairs, all tested through lab experiments. Among the combinations, simvastatin (commonly used to lower cholesterol) and disulfiram (used in alcohol dependence) stood out against breast cancer cells. Some of these combinations show potential for further research in therapeutic repurposing.

These drugs, while not traditionally associated with cancer care, could be potential cancer treatments, although they would first have to go through extensive clinical trials.

“This study demonstrates how AI can be woven directly into the iterative loop of scientific discovery, enabling adaptive, data-informed hypothesis generation and validation in real time,” said Zenil.

“The capacity of supervised LLMs to propose hypotheses across disciplines, incorporate prior results, and collaborate across iterations marks a new frontier in scientific research,” said King. “An AI scientist is no longer a metaphor without experimental validation: it can now be a collaborator in the scientific process.”

The research was supported in part by the Alice Wallenberg Foundation and the UK Engineering and Physical Sciences Research Council (EPSRC).

Find out more about how Cambridge is changing the story of cancer.

Reference:
Abbi Abdel-Rehim et al. ‘Scientific Hypothesis Generation by Large Language Models: Laboratory Validation in Breast Cancer Treatment.’ Journal of the Royal Society Interface (2025). DOI: 10.1098/rsif.2024.0674



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Cambridge researchers awarded £7.5 million to build programmable plants

Gloved hand holding plant in pot
Gloved hand holding plant in pot
Credit: pkujiahe on Getty

Two groups involving researchers from the University of Cambridge’s Department of Plant Sciences are among nine teams to have been awarded funding today from the UK’s Advanced Research + Invention Agency (ARIA)’s Synthetic Plants programme.

We’re building the tools to make plants programmable, just like software. This isn’t science fiction – it’s the future of agriculture.Jake Harris

Imagine a plant with entirely new abilities – more nutritious food, crops that survive heatwaves, or leaves that grow useful materials. With new ARIA funding Cambridge researchers hope to unlock the technology to fast-track crop development and enhance plants with new qualities, like drought-tolerance to reduce the amount of water they need, or the ability to withstand pests and diseases.

Their research has the potential to revolutionise the future of agriculture and offer a radical new approach to securing food supply in the face of climate change.

Programmable plants – a major leap in plant biology

“We’re building the tools to make plants programmable, just like software. This isn’t science fiction – it’s the future of agriculture,” said Professor Jake Harris, Head of the Chromatin and Memory group, and project lead for one of the ARIA-funded projects.

Harris’ team is awarded £6.5 million to build the world’s first artificial plant chromosome.

The ambitious aim of the Synthetic Plants programme is to develop artificial chromosomes and chloroplasts that can survive in a living plant. If the teams achieve this, it will be one the most significant advances in plant synthetic biology.

The international team involves collaborators from The University of Western Australia, biotech company Phytoform Labs and the Australian Genome Foundry at Macquarie University.

“Our idea is that instead of modifying an existing chromosome, we design it from the ground up,” Professor Harris said.

He added: “We’re rethinking what plants can do for us. This synthetic chromosome could one day help grow crops that are more productive, more resilient, and better for the planet.”

While synthetic chromosomes have been achieved in simpler organisms, such as bacteria and yeast, this will be the first attempt to create and deploy one entirely from scratch in a plant.

The project will use the moss Physcomitrium patens – a unique, highly engineerable plant – as a development platform to build and test a bottom-up synthetic chromosome, before transferring it into potato plants.

It also opens new possibilities for growing food and medicines in space, and for indoor agriculture. It could allow scientists to give elite crop varieties disease resistance, or to grow productively in new climates and environments.

Unlocking powerful applications in agriculture

The second funded project, led by Professor Alison Smith and Dr Paweł Mordaka in the Plant Metabolism group, aims to use the synthetic chloroplasts to enable plants to fix nitrogen, and produce vitamin B12. The use of fertilisers to supply nitrogen and promote good crop yields is the greatest cause of pollution from agriculture; reducing the need for these would promote more sustainable food production systems.

This builds on their previous work to design and build the entire chloroplast genome for the simple single-cell alga Chlamydomonas reinhardtii.

The Cambridge researchers are awarded almost £1 million, as part of a £9 million grant to this project. They are working with an international team of researchers from the UK, USA and Germany to transfer this technology to build synthetic chloroplasts in potato plants.

Professor Smith said: “Our success would unlock powerful applications in agriculture, like plants capable of nitrogen fixation or producing essential nutrients like vitamin B12, potentially reducing fertiliser dependence and addressing malnutrition. These traits have tremendous potential should they be engineered into plants.”

She added: “It will enable scientists to surpass what can be accomplished with gene editing and equip plants with new functions, from reducing agricultural water use to protecting crop yields in uncertain conditions.”

A unique opportunity

The ambitiousness of this project is outside the scope of most other UK funding schemes. Professor Harris believes this stems from ARIA’s unique approach to developing the research opportunity and goal along with the research community.

Harris said: “ARIA had a couple of events with synthetic biologists to look at what’s on the edge of possible, what could be useful as a moonshot approach that could really change things.”

He added: “It’s a totally different way of seeing things. We went from ‘here’s what we want to see in the world’ to ‘how are we going to get there?’ It catalysed a different team and a different way of thinking.”

“This work moves us beyond the limitations of natural genomes. It’s about designing entirely new capabilities in plants – from the molecular level up.”

Currently, it typically takes eight years to develop a new crop variety in the UK, but with this new technology it could be a matter of one year or even less. The speed of development would be dramatically increased, much in the way that revolutionary protein-folding technology like AlphaFold has massively accelerated the process of drug discovery.

Synthetic biology is already revolutionising the world of healthcare and could transform agriculture if applied to tailoring plant traits.



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Cambridge is the UK’s most innovation intensive city, says report

Hand holding test tubes in a lab

A new report by Dealroom shows that Cambridge is, for its size, the most innovative city in the UK. Globally, it ranks fourth behind US innovation powerhouses San Francisco, Boston and New York. 

Dealroom’s Global Tech Ecosystem Index analyses and compares start-up ecosystems in 288 cities across 69 countries. To measure innovation intensity, it looks for ecosystems that are performing well relative to their population size. These hubs typically have high start-up activity, research intensity and strong links with local universities.

Diarmuid O’Brien, Pro-Vice-Chancellor for Innovation at the University of Cambridge, said: “It’s great to see that, as a relatively small city, Cambridge continues to lead the UK in innovation intensity but it’s no accident that we punch above our weight. In recent years, the University and the wider ecosystem have put in place a range of initiatives to ensure that we realise our potential and are able to bring transformative science and technologies out of the lab and into the real world.”

Gerard Grech, Head of Founders at the University of Cambridge, which supports new ventures emerging from the University, added: “Cambridge is proof of what happens when world-class research meets relentless ambition. While global venture capital funding in 2024 pulled back, Cambridge doubled investment – a powerful signal that deep tech innovation is increasingly leading the way in shaping our future economies.

“What makes Cambridge unique is its cutting-edge science, an increasing flywheel of people who have successfully scaled ventures, and a culture built to turn ground-breaking ideas into transformative companies.”



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source: cam.ac.uk