Scientists have uncovered the mechanism behind how aspirin could reduce the metastasis of some cancers by stimulating the immune system.

Aspirin has the potential to be less expensive than antibody-based therapies, and therefore more accessible globally.Jie Yang

They say that discovering the mechanism will support ongoing clinical trials, and could lead to the targeted use of aspirin to prevent the spread of susceptible types of cancer, and to the development of more effective drugs to prevent cancer metastasis.

The scientists caution that, in some people, aspirin can have serious side-effects and clinical trials are underway to determine how to use it safely and effectively to prevent cancer spread, so people should consult their doctor before starting to take it.

Studies of people with cancer have previously observed that those taking daily low-dose aspirin have a reduction in the spread of some cancers, such as breast, bowel, and prostate cancers, leading to ongoing clinical trials. However, until now it wasn’t known exactly how aspirin could prevent metastases.

Professor Rahul Roychoudhuri in the Department of Pathology at the University of Cambridge, who led the work, said: “Despite advances in cancer treatment, many patients with early stage cancers receive treatments, such as surgical removal of the tumour, which have the potential to be curative, but later relapse due to the eventual growth of micrometastases – cancer cells that have seeded other parts of the body but remain in a latent state.

“Most immunotherapies are developed to treat patients with established metastatic cancer, but when cancer first spreads there’s a unique therapeutic window of opportunity when cancer cells are particularly vulnerable to immune attack. We hope that therapies that target this window of vulnerability will have tremendous scope in preventing recurrence in patients with early cancer at risk of recurrence.”

The study was published on 5 March in the journal ‘Nature‘.

The scientists say their discovery of how aspirin reduces cancer metastasis was serendipitous. They were investigating the process of metastasis, because, while cancer starts out in one location, 90% of cancer deaths occur when cancer spreads to other parts of the body.

The scientists wanted to better understand how the immune system responds to metastasis, because when individual cancer cells break away from their originating tumour and spread to another part of the body they are particularly vulnerable to immune attack. The immune system can recognise and kill these lone cancer cells more effectively than cancer cells within larger originating tumours, which have often developed an environment that suppresses the immune system. 

The researchers previously screened 810 genes in mice and found 15 that had an effect on cancer metastasis. In particular, they found that mice lacking a gene which produces a protein called ARHGEF1 had less metastasis of various primary cancers to the lungs and liver. 

The researchers determined that ARHGEF1 suppresses a type of immune cell called a T cell, which can recognise and kill metastatic cancer cells. 

To develop treatments to take advantage of this discovery, they needed to find a way for drugs to target it. The scientists traced signals in the cell to determine that ARHGEF1 is switched on when T cells are exposed to a clotting factor called thromboxane A2 (TXA2).

This was an unexpected revelation for the scientists, because TXA2 is already well-known and linked to how aspirin works. 

TXA2 is produced by platelets – a cell in the blood stream that helps blood clot, preventing wounds from bleeding, but occasionally causing heart attacks and strokes. Aspirin reduces the production of TXA2, leading to the anti-clotting effects, which underlies its ability to prevent heart attacks and strokes. 

This new research found that aspirin prevents cancers from spreading by decreasing TXA2 and releasing T cells from suppression. They used a mouse model of melanoma to show that in mice given aspirin, the frequency of metastases was reduced compared to control mice, and this was dependent on releasing T cells from suppression by TXA2.

Dr Jie Yang in the Department of Pathology at the University of Cambridge, first author of the report, said: “It was a Eureka moment when we found TXA2 was the molecular signal that activates this suppressive effect on T cells. Before this, we had not been aware of the implication of our findings in understanding the anti-metastatic activity of aspirin. It was an entirely unexpected finding which sent us down quite a different path of enquiry than we had anticipated.” 

“Aspirin, or other drugs that could target this pathway, have the potential to be less expensive than antibody-based therapies, and therefore more accessible globally.”

In the future, the researchers plan to help the translation of their work into potential clinical practice by collaborating with Professor Ruth Langley, of the MRC Clinical Trials Unit at University College London, who is leading the Add-Aspirin clinical trial, to find out if aspirin can stop or delay early stage cancers from coming back. 

Professor Langley, who was not involved in this study, commented: “This is an important discovery. It will enable us to interpret the results of ongoing clinical trials and work out who is most likely to benefit from aspirin after a cancer diagnosis.” 

“In a small proportion of people, aspirin can cause serious side-effects, including bleeding or stomach ulcers. Therefore, it is important to understand which people with cancer are likely to benefit.”

The research was principally funded by the Medical Research Council, with additional funding from the Wellcome Trust and European Research Council. 

The Add-Aspirin clinical trial is funded by Cancer Research UK, the National Institute for Health and Care Research, the Medical Research Council and the Tata Memorial Foundation of India. 

Reference: J Yang, et al: “Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity.” Nature, March 2025. DOI: 10.1038/s41586-025-08626-7

Adapted from a press release by the Medical Research Council.

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A ‘chasm of misunderstanding and miscommunication’ is often experienced between clinicians and patients, leading to autoimmune diseases such as lupus and vasculitis being wrongly diagnosed as psychiatric or psychosomatic conditions, with a profound and lasting impact on patients, researchers have found.

These types of misdiagnoses can create a multitude of negative feelings and impacts on lives, self-worth and care – Mel Sloan

A study involving over 3,000 participants – both patients and clinicians – found that these misdiagnoses (sometimes termed “in your head” by patients) were often associated with long term impacts on patients’ physical health and wellbeing and damaged trust in healthcare services.

The researchers are calling for greater awareness among clinicians of the symptoms of such diseases, which they recognise can be difficult to diagnose, and for more support for patients.

Autoimmune rheumatic diseases such as rheumatoid arthritis, lupus and vasculitis are chronic inflammatory disorders that affect the immune system and can damage organs and tissues throughout the body. They can be very difficult to diagnose as people report a wide range of different symptoms, many of which can be invisible, such as extreme fatigue and depression.

Dr Melanie Sloan from the University of Cambridge led a study exploring patient-reported experiences from two large groups, each of over 1,500 patients, and in-depth interviews with 67 patients and 50 clinicians. The results are published today in Rheumatology.

Patients who reported that their autoimmune disease was misdiagnosed as psychosomatic or a mental health condition were more likely to experience higher levels of depression and anxiety, and lower mental wellbeing. For example, one patient with multiple autoimmune diseases said: “One doctor told me I was making myself feel pain and I still can’t forget those words. Telling me I’m doing it to myself has made me very anxious and depressed.”

More than 80% said it had damaged their self-worth and 72% of patients reported that the misdiagnosis still upset them, often even decades later. Misdiagnosed patients also reported lower levels of satisfaction with every aspect of medical care and were more likely to distrust doctors, downplay their symptoms, and avoid healthcare services. As one patient reported, it “has damaged my trust and courage in telling doctors very much. I even stopped taking my immunosuppressive medicine because of those words”.

Following these types of misdiagnoses, patients often then blamed themselves for their condition, as one individual described: “I don’t deserve help because this is a disease I’ve brought on myself. You go back to those initial diagnosis, you’ve always got their voices in your head, saying you’re doing this to yourself. You just can’t ever shake that. I’ve tried so hard.”

One patient described the traumatising response their doctor’s judgement had on them: “When a rheumatologist dismissed me I was already suicidal, this just threw me over the edge. Thankfully I am terrible at killing myself, it’s so much more challenging than you think. But the dreadful dismissiveness of doctors when you have a bizarre collection of symptoms is traumatizing and you start to believe them, that it’s all in your head.”

Dr Melanie Sloan, from the Department of Public Health and Primary Care at the University of Cambridge, said: “Although many doctors were intending to be reassuring in suggesting a psychosomatic or psychiatric cause for initially unexplainable symptoms, these types of misdiagnoses can create a multitude of negative feelings and impacts on lives, self-worth and care. These appear to rarely be resolved even after the correct diagnoses. We must do better at helping these patients heal, and in educating clinicians to consider autoimmunity at an earlier stage.”      

Clinicians highlighted how hard it was to diagnose autoimmune rheumatic diseases and that there was a high risk of misdiagnosis. Some doctors said they hadn’t really thought about the long-term problems for patients, but others talked about the problems in regaining trust, as one GP from England highlighted: “They lose trust in anything that anyone says…you are trying to convince them that something is OK, and they will say yes but a doctor before said that and was wrong.”

However, there was evidence that this trust can be rebuilt. One patient described having been “badly gaslit by a clinician”, but that when they told the clinician this, “She was shocked and had no idea … She was great. Took it on the chin. Listened and heard. Apologised profusely…For me, the scar of the original encounter was transformed into something much more positive.”

Mike Bosley, autoimmune patient and co-author on the study, said: “We need more clinicians to understand how a misdiagnosis of this sort can result in long-standing mental and emotional harm and in a disastrous loss of trust in doctors. Everyone needs to appreciate that autoimmune conditions can present in these unusual ways, that listening carefully to patients is key to avoiding the long-lasting harm that a mental health or psychosomatic misdiagnosis can cause.”

The study authors recommend several measures for improving support for patients with autoimmune rheumatological diseases. These are likely to apply for many other groups of patients with chronic diseases that are often misunderstood and initially misdiagnosed.

They propose that clinicians should talk about previous misdiagnoses with patients, discuss and empathise with their patients as to the effects on them, and offer targeted support to reduce the long-term negative impacts. Health services should ensure greater access to psychologists and talking therapies for patients reporting previous misdiagnoses, which may reduce the long-term impact on wellbeing, healthcare behaviours, and patient-doctor relationships. Education may reduce misdiagnoses by encouraging clinicians to consider systemic autoimmunity when they assess patients with multiple, seemingly unconnected, physical and mental health symptoms.

Professor Felix Naughton, from the Lifespan Health Research Centre at the University of East Anglia, said: “Diagnosing autoimmune rheumatic diseases can be challenging, but with better awareness among clinicians of how they present, we can hopefully reduce the risk of misdiagnoses. And while there will unfortunately inevitably still be patients whose condition is not correctly diagnosed, with the correct support in place, we may be able to lessen the impact on them.”

The research was funded by LUPUS UK and The Lupus Trust.

Reference
Sloan, M, et al. “I still can’t forget those words”: mixed methods study of the persisting impacts of psychosomatic and psychiatric misdiagnoses. Rheumatology; 3 Mar 2025; DOI: 10.1093/rheumatology/keaf115

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Cambridge geoscientists are developing an atlas that could lead to a more complete understanding of how viable rare earth element deposits form and help locate more secure sources, by mapping the global distribution of critical metals deposits within unusual igneous rocks.

These are critical raw materials; critical both because we need them in almost every gadget and technology, but also because the supply chain is so precarious – Sally Gibson

Rare earth elements are vital components in many everyday and high-tech devices, from smartphones and lightbulbs to clean energy solutions like wind turbines and electric vehicles.

With the global shift towards low-carbon energy sources, the demand for rare earths is soaring. While there are rare earth deposits around the world, China dominates the global supply chain, accounting for 70% of rare earth ore extraction and 90% of rare earth ore processing. The UK and EU currently have no domestic source or refining capabilities, leading to concerns over the security of supplies.

“These are critical raw materials; critical both because we need them in almost every gadget and technology, but also because the supply chain is so precarious,” said Professor Sally Gibson from Cambridge’s Department of Earth Sciences.

US President Trump’s recent statements about accessing rare earth deposits in Greenland and Ukraine have once again highlighted the need for countries to find new ways to secure these vital minerals.

“We really need to identify rare earth deposits which have a security of supply,” said Gibson, who currently holds a £1-million project to investigate how rare earth element deposits form, research that could help guide efforts to pinpoint new, economically viable sources.

Rare earth deposits are typically associated with a type of igneous rock called carbonatite. Packed full of calcium, these rocks are unlike other magmas because their chemistry is rich in CO2 and rare earth elements.

Gibson has been studying carbonatites for around 30 years. “Carbonatites have long been seen as geological curiosities, things that no one was that interested in in terms of big-picture science,” she said.

But that outlook has changed in recent years, she added, as the need for rare earths has come to the fore. “How these rocks form is becoming an increasingly important question.”

It’s a question that many geoscientists are asking, but what makes Gibson’s project unique is that, rather than focusing on how individual localities or ‘provinces’ of rare earth deposits form, she is zooming out and examining their global distribution.

Gibson and her colleagues are also looking deeper into Earth’s interior for clues that might explain the surface expression of carbonatites. Project co-lead, Professor Sergei Lebedev, also from Cambridge Earth Sciences, is a geophysicist who uses earthquake waves to ‘see’ into the Earth’s interior, similar to how sonar pings can pick out features on the seabed.

“By combining the geophysical and geochemical evidence, we are learning more about both the deep dynamics and evolution of the Earth’s continents, and the generation of carbonatites and the associated mineral resources,” Lebedev said.

The REE-LITH project was inspired by Gibson and Lebedev’s hunch that differences in the properties of Earth’s lithosphere – the outermost layers of our planet’s structure – might play a guiding role in where carbonatites form, and perhaps their level of rare earth element enrichment.

“We know that lithospheric thickness matters for other special igneous rocks that host diamonds,” said Gibson. “Typically, diamond-hosting ‘kimberlite’ rocks only occur in areas where the lithosphere is particularly thick. I thought it was time we tested if there was a similar relationship for carbonatites.”

Mapping Rare Earths

Over the last year, the team, which includes postdoctoral researchers Siyuan Sui and Emilie Bowman from Cambridge, have been building their new map, drawing on a bank of data on carbonatites and related rare earth deposits and combining this with information about the lithosphere.

As part of this mission, Sui has been using new seismic data extracted from earthquakes to create computer-generated images of the lithosphere, its thickness and other properties. Alongside this, Bowman has been running statistical analyses of geochemical data on magmas to test their relationship to associated rare earth deposits. 

When the researchers started to plot occurrences of carbonatites on a map of lithosphere thickness, they quickly saw a pattern.

“We can already tell that carbonatites occur in specific areas, limited to the steep margins that border Earth’s thickest and oldest lithosphere,” said Gibson. “These regions are typically found in the cores of our planet’s major continents.”

Gibson said that while the resolution of their map is increasing, and they can narrow down the regions where carbonatites should occur, they now need to establish why only certain carbonatites generate economically important rare earths. “Having some kind of model that could predict the most likely locations for rare earth deposits is really the ultimate goal for many geologists,” she said.

Collaboration will be key to unlocking that mystery, Gibson said. Her project brings together researchers from across Cambridge Earth Sciences, drawing on the extensive bank of seismic data collected by geophysicists at the Bullard Laboratory and the Department’s expertise in igneous petrology and geochemistry. The team also includes collaborators at the Universities of St Andrews and Exeter.

“Without that multidisciplinary approach, we wouldn’t have been able to pick out these global-scaled patterns in carbonatite occurrence,” she said.

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Covid-19 showed us how vulnerable the world is to pandemics – but what if the next pandemic were somehow engineered? How would the world respond – and could we stop it happening in the first place?

There is a great opportunity to take a joined-up approach to managing the risks posed by engineered pandemics – Clare Bryant

These are some of the questions being addressed by a new initiative launched today at the University of Cambridge, which seeks to address the urgent challenge of managing the risks of future engineered pandemics.

The Engineered Pandemics Risk Management Programme aims to understand the social and biological factors that might drive an engineered pandemic and to make a major contribution to building the UK’s capability for managing these risks. It will build a network of experts from academia, government, and industry to tackle the problem.

Increased security threats from state and non-state actors, combined with increased urbanisation and global mobility, means the threat of deliberate pathogen release must be taken seriously as must other intertwined aspects of pandemic risk such as mis- and disinformation, the erosion of trust in a number of institutions and an increasingly volatile geopolitical context. Further potential risks are posed by recent developments in gene-editing tools and artificial intelligence, which have rapidly advanced technological capability that may make it easier to engineer potential pandemic pathogens.

Professor Clare Bryant from the Department of Medicine at the University of Cambridge said: “There is a great opportunity to take a joined-up approach to managing the risks posed by engineered pandemics. We need experts and agencies across the spectrum to work together to develop a better understanding of who or what might drive such events and what their likely impact would be. And we need evidence-informed policies and networks in place that would help us respond to – or better still, prevent – such an eventuality.”

• The aims of the Engineered Pandemics Risk Management Programme are:
• To develop the conceptual underpinnings for the risk management of engineered pandemics based on interdisciplinary research
• To support the capability of the UK’s engineered pandemic risk policy and practice, including building and maintaining networks that connect government, academia and industry.
• To strengthen the international networks that will support this work globally

There are four main strands of work:

Social determinants of engineered pandemic threat

This strand will look at the actors who have the potential to engineer harmful pathogens, either deliberately or accidentally. It will ask questions such as: What could motivate bioterrorism in the coming decades? Who might the relevant actors be? What are the kinds of engineered pandemic that someone might want to create?

Dr Rob Doubleday, Executive Director of the Centre for Science and Policy at the University of Cambridge, said: “The common narrative is that there’s a wide range of potential actors out there who want to create bioweapons but don’t yet have the technical means. But in fact, there’s been very little work to really understand who these people might be, and their relationship to emerging technology. To explore these questions, we need a broad network including social scientists, biosecurity researchers, criminologists, experts in geopolitics and counterterrorism.”

The strand will also look at the governance of scientific research in areas that may facilitate an engineered pandemic, whether unwittingly or maliciously, aiming to deliver a policy framework that enables freedom of intellectual research while managing real and apparent risk in infectious disease research.

Professor Bryant said: “As scientists, we’re largely responsible for policing our own work and ensuring integrity, trustworthiness and transparency, and for considering the consequences of new knowledge and how it might be used. But with the rapid progress of genomic technologies and AI, self-regulation becomes more difficult to manage. We need to find governance frameworks that balance essential scientific progress with its potential misapplication.”

Biological determinants of engineered pandemic threat

Recognising that the most likely cause of an engineered pandemic would be the deliberate release of a naturally-occurring pathogen – viral or bacterial, for example – rather than a man-made pathogen, this strand aims to understand what might make a particular pathogen infectious and how our immune systems respond to infection. This knowledge will allow researchers to screen currently available drugs to prevent or treat infection and to design vaccines quickly should a pandemic occur.

Modelling threats and risk management of engineered pandemics

The Covid-19 pandemic highlighted practical problems of dealing with pandemic infections, from the provision of personal protective equipment (PPE) to ensuring a sufficient supply of vaccine doses and availability of key medications. Modelling the potential requirements of a pandemic, how they could be delivered, how ventilation systems could be modified, what biosafety measures could be taken, for example, are all key challenges for managing any form of pandemic. This strand will address how existing modelling approaches would need to be adapted for a range of plausible engineered pandemics.

Policy innovation challenges

Working with the policy community, the Cambridge team will co-create research that directly addresses policy needs and involves policy makers. It will support policy makers in experimenting with more joined-up approaches through testing, learning and adapting solutions developed in partnership.

The Engineered Pandemics Risk Management Programme is supported by a £5.25 million donation to the Centre for Research in the Arts, Humanities and Social Sciences (CRASSH) at the University of Cambridge. The team intends it to form a central component of a future Pandemic Risk Management Centre, for which it is now fundraising.

Professor Joanna Page, Director of CRASSH, said: “Cambridge has strengths across a broad range of disciplines – from genetics and immunology to mathematical modelling to existential risk and policy engagement – that can make a much-needed initiative such as this a success.”

To find out more, visit the Engineered Pandemic Risk Management website.

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The dying signal of a seismometer being engulfed by molten lava has been transformed into artwork as part of a pioneering new exhibition showcasing the awesome power of volcanoes.

The instrument’s final moments measuring the eruption near Grindavík in Iceland on January 14, 2024 have been audified for the immersive Magma Rising display at Downing College’s Heong Gallery, which takes visitors on a journey through the centre of an eruption.

Iceland is one of the most volcanically active regions on Earth. Since 2021, there have been 10 eruptions on Iceland’s Reykjanes Peninsula, which have garnered worldwide attention and captured the imagination of the public.

Now – inspired by the research in Iceland of Cambridge University volcanologists and seismologists – the new exhibition showcases a unique combination of science and visual arts, that includes works by Icelandic singer-songwriter Björk, filmmaker Werner Herzog, and BAFTA-award-winning Xbox Game Studio Ninja Theory. 

Magma Rising, guest curated by artist Dr Sara Rawlinson, is the first of the Gallery’s new ‘Visual Enquiries’ exhibitions, which presents academic research from within the Cambridge community and beyond.

Dr Rawlinson – who was a seismologist in her previous career – said volcanic eruptions are among the most spectacular manifestations of our dynamic planet. “For me, they are the ultimate ‘untouchable’ – you really can’t get too close, but if you see one you never forget it. Volcanoes can be so explosive that they can change the face of world climate for a year or more. They are the most awe-inspiring phenomenon, and that’s what the exhibition conveys. It’s bridging the art-science divide and enveloping the visitor in this experience that becomes more and more magnified the further to the centre you get.”

A wide selection of artwork – including films and video games, sculptures, microscope imagery, shoe design, illustrations, printmaking, paintings, photography, and a large-scale wall mural – is interwoven with scientific data and samples, heritage objects, and historic documents. In total, the show comprises work by 20 artists, complemented by 36 artefacts drawn from three museums.

Sound artist and composer David Stalling’s audification of Cambridge seismologist Professor Nick Rawlinson’s melting seismometer will accompany people through the exhibition ‘volcano’ – part of a concert of sounds made entirely from seismic data, which also includes the North Atlantic seafloor excited by currents, the calls of whales, and the hum of ships.

The equipment was swallowed beneath 20 metres of lava – with a temperature of around 1200 °C – while Prof Rawlinson, a Downing Fellow, was conducting  fieldwork on the Reykjanes Peninsula.

He said: “The Mid-Atlantic Ridge runs through the Peninsula, pulling it apart and opening up fissures which lava fountains up through in an effusive eruption. But we don’t know exactly when and where it will take place, and unfortunately one opened up not far from the instrument. We didn’t have time to save it, but we could hear the real-time signal which was really interesting – this background seismicity that dies off just before the eruption and then this huge surge as the lava comes to the surface. It gets bigger and bigger and then just cuts off. The composition is hard to put into words – it’s very unique.”

Cambridge volcanologist Prof Clive Oppenheimer’s collaboration with filmmaker Werner Herzog on the 2016 Netflix documentary Into the Inferno also features in the exhibition, along with props from the film. And award-winning video game studio Ninja Theory’s work recreating the stunning Icelandic lava flows in Senua’s Saga: Hellblade II will be exhibited alongside Björk’s Sorrowful Soil music video, filmed close to the recently erupted Fagradalsfjall volcano .

Dr Rachel Coombes, Cambridge University art historian and Keeper of the Gallery at Downing College, said: “Magma Rising  is the first exhibition in our new ‘Visual Enquiries’ strand, which pairs the visual arts with academic research being undertaken within the Cambridge community. We’re taking academic stimuli that are often kept in the classroom and bringing them to the broader public, through impactful artwork. For this exhibition, there are a lot of artists who are really interested in these amazing natural phenomena and Sara has been working carefully on how this stuff can come together in our space. We’re confident the exhibition will create a lot of excitement.”

Magma Rising: A Journey to the Centre of Icelandic Volcanoes runs 26 February to 22 April at The Heong Gallery, Downing College. Opening times are 12pm to 5pm Wednesdays to Sundays, and admission is free.

The exhibition will be accompanied by an ambitious set of outreach events (nearly every weekend), many of which coincide with British Science Week (8-17 March), the Cambridge Festival (20 March – 6 April), and Earth Day (22 April). Planned events include film showings, a panel discussion about filming active lava, a drawing session with volcanic ash, musical performances, lava flow modelling, a seismometer demonstration and more.

For more information visit: magmarising.org

Words: Stephen Bevan
Published: 26th February, 2025

The text in this work is licensed under a Creative Commons Attribution 4.0 International License.

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Duygu Sevilgen is enriching our understanding of life on the reef.

By Liam Morgan

Corals are animals, not plants. They are the quirky, sedentary members of the Cnidaria family: unlike their jellyfish cousins, they build skeletons and don’t move.

Healthy coral reefs are the rainforests of the ocean, a nursery for young fish, and a shelter for countless other species. They are a massive natural barrier for coastlines, breaking up violent waves before they hit land.

But due to the impacts of human-caused climate change, these wonders of the natural world are at risk. As extreme weather increases in severity and the ocean warms, corals are suffering.

If their shallow water environment is unstable for long enough, corals will die. We see this in the massive coral bleaching events plaguing reefs around the world, reducing them to rubble.

If we don’t stop global temperatures from rising – both on land and at sea – the world’s great reefs could become coral graveyards.

Duygu Sevilgen, Research Associate in Earth Sciences and Plant Sciences, wants to understand how corals build their skeletons. To do this, she uses homemade ’microsensors’ to measure the finest details and probe the corals’ symbiotic relationships. In doing so, Duygu is determining how much change corals can bear, and improving our chances of saving them.

Duygu’s life in marine biology started with a plunge into the Tyrrhenian Sea. She learned to dive off the coast of Elba, the island where Napoleon was first exiled (and shortly escaped from).

Moving south, Duygu caught her first sight of corals in the Red Sea. What she saw in those shallow waters took her breath away. Such a vibrant overflow of life felt illusory. HD television documentaries did not do the reefs justice.

“Coral reefs are beautiful and complex. They are astonishingly colourful. Observing them is surprisingly funny, with curious fish darting between their branches,” says Duygu. “They offer a biodiversity we rarely see in other ecosystems.”

“Corals offer a biodiversity we rarely see in other ecosystems.”Duygu Sevilgen

Close up of a Pocillopora meandrina colony, with happily extended polyps. Image by Madison East.

But when corals die, the entire ecosystem dies with them. When they become rubble, they can no longer offer sanctuary and protection. To offer them the best chances of survival, understanding the peculiar life of corals is vital.

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Duygu’s microsensors

Born and raised in Germany, Duygu studied biology in Cologne. From there she moved to Bremen, a renowned hub for marine research. 

At the Max Planck Institute for Marine Microbiology, she was part of Dirk de Beer’s Microsensor Working Group, where she learned how to build microsensors capable of measuring an environment in meticulous detail. 

Microsensors have their origin in neurobiology. Scientists started using them for environmental studies in the 1980s. People like Niels Peter Revsbech at Aarhus University were among the first to develop new sensors for uses in microbial ecology.

Microsensors are superfine needles, with a micrometre-diameter tip. For scale, a micrometre is one-thousandth of a millimetre: about the length of a single bacterium, or 4 times thinner than a spider’s silk. They allow us to measure chemical changes faster than the time it takes a housefly to flap its wings. They are one of a very few methods that lets scientists measure what’s happening inside a live coral.

Since her time in Bremen, Duygu has set up sensors both in the lab and the ocean, where diving allows her to gather data from the seabed, sometimes with the help of underwater robots.

After bringing her microsensor research to the Scientific Centre in Monaco, Duygu heard about the work of Oscar Branson at Cambridge. Oscar was setting up a coral lab to study biomineralisation (a fancy word for ‘how to make a skeleton’), and asked Duygu to join his group.

Cambridge presented Duygu with her current mission: to grow corals in captivity and uncover the secrets of their skeletons.

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Growing corals in the lab

Branches of an Acropora sp. showing the axial and radial corallites. The branches are around 1cm across. Image by Madison East.

How do corals respond to temperature changes in the surrounding water? Or the acidity levels of the ocean? Where are their climatic limits and how do different coral species compare?

These are some of the questions Duygu and the rest of Oscar’s team hope to answer. Their work extends to other marine ‘biomineralisers’ such as foraminifera – single-celled organisms that build shells. 

To bring these skeletons out of the closet, the team has built a coral lab in the basement of an old Cambridge Zoology building. 

The lab hosts two main coral tanks. Inside these lie multicoloured miniature forests, whose branches reach out to meet small crabs and fish. Conditions are tuned for optimum coral happiness, mimicking their ecosystem in the wild. 

In the wider lab sit 10 experimental tanks, each representing a different environment. 

“We can alter a lot of the environment in our experimental tanks, changing the temperature, light and the chemical makeup,” Duygu says. “We use the tanks to conduct our experiments. We want to see how the corals and other biomineralisers can keep up with environmental changes.”

In nature, all species on a reef interact and play a role in the health of the ecosystem. Duygu watches the captive corals closely as she tweaks their conditions, and logs how they respond. 

“We can’t recreate everything. Many reef players are missing. We don’t recreate seasons, and we can’t recreate the soundscape of the reef – which, amazingly, has been shown to be very important for ecosystem health. However, our studies will illuminate the corals’ fundamental mechanisms.”

Other group members work on different aspects of coral biomineralisation. PhD student Alice Ball and postdoc Nishant Chauhan focus on physiology and how environmental changes affect coral respiration, photosynthesis, calcification, and gene expression. Madison East uses computer modelling techniques to understand how corals control their crystallisation processes. 

Madison also takes incredible photos, both with the scanning electron microscope and her camera. She works with the photogenic foraminifera, single-celled organisms made famous by the psychedelic illustrations of Ernst Haeckel, whose grandson was a cruise leader on one of Duygu’s deep sea expeditions.

Exactly how corals construct their intricate skeletons is not fully understood. What we know so far suggests that bone-weaving requires tenacity and patience.

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Skeleton quay

An Acropora colony recovering from fragging, a process used in coral research to propagate specimens and create replicates. The colony doesn’t skip a beat and simply regrows a new tip. Image by Madison East.

Corals combine ocean salts and carbon to make their skeletons. They use calcium and carbon from seawater, and craft these into an intricate skeleton that is integral to their survival.

Some species use their skeletons to branch out, forming massive 3D structures. The corals Duygu keeps are not a single animal – they are actually colonies of thousands of individual polyps. 

Polyps of Duygu’s corals look a bit like a rubber glove, with 6 (or a multiple of 6) tentacles. Their skeleton is covered by tissue, like the skin covering our bones. Individual polyps are connected through this tissue, allowing them to communicate. If you touch one, the polyp will inform its fellow colony members of danger, and those nearby will retract. 

In tissue pockets, the corals host a useful partner, their symbiotic algae. Named zooxanthellae, these algae bring the power of photosynthesis to the colony. 

Zooxanthellae use the sunlight that penetrates shallow waters. Just like plants, they photosynthesise: transforming light and carbon dioxide into oxygen and food for the coral, paying rent for their tissue tenancy. 

The zooxanthellae bring a brownish, greenish colour to the coral colony. But if the environmental conditions become too hot or acidic, they leave, taking the colour with them. This leads to bleached coral reefs, where white coral skeletons show through transparent tissue. 

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A certain future

Cross-section of an Acropora cf. austera branch, revealing the central column of the axial corallite. The corallite is the skeletal cup in which a polyp sits. It is divided up by radiating septa, revealing the 6-fold symmetry. Image by Madison East.

The ocean has a natural variability, with 5-to-10-year cycles of fluctuating temperatures. However, the CO2 humans have released is causing the world to warm. Much of that extra heat goes into the ocean.

When natural climate oscillations coincide with a warming planet, corals experience never-before-seen conditions. This is driving increasingly severe coral bleaching and death. Six of the worst recorded global bleaching events have occurred in the last 20 years.

“What we see in the oceans now is the cumulative effect of what we did on land, since the industrial revolution,” says Duygu. “It’s a delayed fuse.” 

The only certainty is that if we do nothing, the coral reefs and the biodiversity that comes with them will disappear with alarming speed. Scientists like Duygu are uncovering the hidden lives of corals, and the conditions they need to survive, before it’s too late.

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Published on 25 February 2025

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A new study led by the University of Cambridge has revealed that as our springs and summers get hotter and drier, the UK wildfire season is being stretched and intensified.

Peatland fires are responsible for a disproportionately large amount of the carbon emissions caused by UK wildfires, which we project will increase even more with climate changeAdam Pellegrini

More fires, taking hold over more months of the year, are causing more carbon to be released into the atmosphere as carbon dioxide.

Fires on peatlands, which are carbon-rich, can almost double global fire-driven carbon emissions. Researchers found that despite accounting for only a quarter of the total UK land area that burns each year, dwarfed by moor and heathland, wildfires that burn peat have caused up to 90% of annual UK fire-driven carbon emissions since 2001 – with emissions spikes in particularly dry years.

Peat only burns when it’s hot and dry enough – conditions that are occurring more often with climate change. The peatlands of Saddleworth Moor in the Peak District, and Flow Country in northern Scotland, have both been affected by huge wildfires in recent years.

Unlike heather moorland which takes up to twenty years to regrow after a fire, burnt peat can take centuries to reaccumulate. The loss of this valuable carbon store makes the increasing wildfire frequency on peatlands a real cause for concern. 

The researchers also calculated that carbon emissions from fires on UK peatland are likely to rise by at least 60% if the planet warms by 2^oC. 

The findings, which are broadly relevant to peatlands in temperate climates, are published today in the journal ‘Environmental Research Letters’.

“We found that peatland fires are responsible for a disproportionately large amount of the carbon emissions caused by UK wildfires, which we project will increase even more with climate change,” said Dr Adam Pellegrini in the University of Cambridge’s Department of Plant Sciences, senior author of the study.

He added: “Peatland reaccumulates lost carbon so slowly as it recovers after a wildfire that this process is limited for climate change mitigation. We need to focus on preventing that peat from burning in the first place, by re-wetting peatlands.”

“We found that in dry years, peatland wildfires were able to burn into the peat and release significant quantities of carbon into the atmosphere. In particularly dry years this contributed up to 90% of the total wildfire-driven carbon emissions from the UK,” said Dr Sarah Baker, lead author of the study which she conducted while at the University of Cambridge. Baker is now based at the University of Exeter.

The researchers found that the UK’s ‘fire season’ – when fires occur on natural land – has lengthened dramatically since 2011, from between one and four months in the years 2011-2016 to between six and nine months in the years 2017-2021. The change is particularly marked in Scotland, where almost half of all UK fires occur.

Nine percent of the UK is covered by peatland, which in a healthy condition removes over three million tonnes of carbon dioxide from the atmosphere per year. 

The researchers estimate 800,000 tonnes of carbon were emitted from fires on UK peatlands between 2001 and 2021. The 2018 Saddleworth Moor fire emitted 24,000 tonnes of carbon, and the 2019 Flow Country fire emitted 96,000 tonnes of carbon from burning peat.

To get their results, the researchers mapped all UK wildfires over a period of 20 years – assessing where they burn, whether peat burned, how much carbon they emit, and how climate change is affecting fires. This involved combining data on fire locations, vegetation type and carbon content, soil moisture, and peat depth. Using UK Met Office model outputs, the team also used simulated climate conditions to project how wildfires in the UK could change in the future.

The study only considered land where wildfires have occurred in the past, and did not consider the future increases in burned area that are likely to occur with hotter, drier UK summers.

An average of 5,600 hectares of moor and heathland burns across the UK each year, compared to 2,500 hectares of peatland.

“Buffering the UK’s peatlands against really hot, dry summers is a great way to reduce carbon emissions as part of our goal to reach net zero. Humans are capable of incredible things when we’re incentivised to do them,” said Pellegrini.

The research was funded by Wellcome, the Isaac Newton Trust and UKRI.

Reference: Baker, S J et al: ‘Spikes in UK wildfire emissions driven by peatland fires in dry years.’ February 2025, Environmental Research Letters. DOI: 10.1088/1748-9326/adafc6.
 

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The UK government’s proposed ‘rights reservation’ model for AI data mining tells British artists, musicians, and writers that “tech industry profitability is more valuable than their creations” say leading academics.

We will only get results that benefit all of us if we put people’s needs before tech companiesGina Neff

The UK government should resist allowing AI companies to scrape all copyrighted works unless the holder has actively ‘opted out’, as it puts an unfair burden on up-and-coming creative talents who lack the skills and resources to meet legal requirements.

This is according to a new report from University of Cambridge experts in economics, policy and machine learning, who also argue the UK government should clearly state that only a human author can hold copyright – even when AI has been heavily involved.

A collaboration between three Cambridge initiatives – the Minderoo Centre for Technology and Democracy, the Bennett Institute for Public Policy, and ai@cam – the report argues that unregulated use of generative AI will not guarantee economic growth, and risks damaging the UK’s thriving creative sector. 

If the UK adopts the proposed ‘rights reservation’ for AI data mining, rather than maintaining the legal foundation that automatically safeguards copyright, it will compromise the livelihoods of many in the sector, particularly those just starting out, say researchers.

They argue that it risks allowing artistic content produced in the UK to be scraped for endless reuse by offshore companies.

“Going the way of an opt-out model is telling Britain’s artists, musicians, and writers that tech industry profitability is more valuable than their creations,” said Prof Gina Neff, Executive Director at the Minderoo Centre for Technology and Democracy.

“Ambitions to strengthen the creative sector, bolster the British economy and spark innovation using GenAI in the UK can be achieved – but we will only get results that benefit all of us if we put people’s needs before tech companies.”

‘Ingested’ by technologies

Creative industries contribute around £124.6 billion or 5.7% to the UK’s economy, and have a deep connection to the tech industry. For example, the UK video games industry is the largest in Europe, and contributed £5.12 billion to the UK economy in 2019.

While AI could lead to a new generation of creative companies and products, the researchers say that little is currently known about how AI is being adopted within these industries, and where the skills gaps lie.

“The Government ought to commission research that engages directly with creatives, understanding where and how AI is benefiting and harming them, and use it to inform policies for supporting the sector’s workforce,” said Neil Lawrence, DeepMind Professor of Machine Learning and Chair of ai@cam.

“Uncertainty about copyright infringement is hindering the development of Generative AI for public benefit in the UK. For AI to be trusted and widely deployed, it should not make creative work more difficult.”

In the UK, copyright is vested in the creator automatically if it meets the legal criteria. Some AI companies have tried to exploit ‘fair dealing’ – a loophole based around use for research or reporting – but this is undermined by the commercial nature of most AI.

Now, some AI companies are brokering licensing agreements with publishers, and the report argues this is a potential way to ensure creative industries are compensated.

While rights of performers, from singers to actors, currently cover reproductions of live performances, AI uses composites harvested from across a performer’s oeuvre, so rights relating to specific performances are unlikely to apply, say researchers.

Further clauses in older contracts mean performers are having their work ‘ingested’ by technologies that didn’t exist when they signed on the dotted line.

The researchers call on the government to fully adopt the Beijing Treaty on Audio Visual Performance, which the UK signed over a decade ago but is yet to implement, as it gives performers economic rights over all reproduction, distribution and rental.

“The current lack of clarity about the licensing and regulation of training data use is a lose-lose situation. Creative professionals aren’t fairly compensated for their work being used to train AI models, while AI companies are hesitant to fully invest in the UK due to unclear legal frameworks,” said Prof Diane Coyle, the Bennett Professor of Public Policy.

“We propose mandatory transparency requirements for AI training data and standardised licensing agreements that properly value creative works. Without these guardrails, we risk undermining our valuable creative sector in the pursuit of uncertain benefits from AI.”

‘Spirit of copyright law’

The Cambridge experts also look at questions of copyright for AI-generated work, and the extent to which ‘prompting’ AI can constitute ownership. They conclude that AI cannot itself hold copyright, and the UK government should develop guidelines on compensation for artists whose work and name feature in prompts instructing AI.

When it comes to the proposed ‘opt-out’ solution, the experts it is not “in the spirit of copyright law” and is difficult to enforce. Even if creators do opt out, it is not clear how that data will be identified, labelled, and compensated, or even erased.

It may be seen as giving ‘carte blanche’ to foreign-owned and managed AI companies to benefit from British copyrighted works without a clear mechanism for creators to receive fair compensation.

“Asking copyright reform to solve structural problems with AI is not the solution,” said Dr Ann Kristin Glenster, Senior Policy Advisor at the Minderoo Centre for Technology and lead author of the report.

“Our research shows that the business case has yet to be made for an opt-out regime that will promote growth and innovation of the UK creative industries.

“Devising policies that enable the UK creative industries to benefit from AI should be the Government’s priority if it wants to see growth of both its creative and tech industries,” Glenster said.

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Researchers have developed comfortable, washable ‘smart pyjamas’ that can monitor sleep disorders such as sleep apnoea at home, without the need for sticky patches, cumbersome equipment or a visit to a specialist sleep clinic.

We need something that is comfortable and easy to use every night, but is accurate enough to provide meaningful information about sleep qualityLuigi Occhipinti

The team, led by the University of Cambridge, developed printed fabric sensors that can monitor breathing by detecting tiny movements in the skin, even when the pyjamas are worn loosely around the neck and chest.

The sensors embedded in the smart pyjamas were trained using a ‘lightweight’ AI algorithm and can identify six different sleep states with 98.6% accuracy, while ignoring regular sleep movements such as tossing and turning. The energy-efficient sensors only require a handful of examples of sleep patterns to successfully identify the difference between regular and disordered sleep.

The researchers say that their smart pyjamas could be useful for the millions of people in the UK who struggle with disordered sleep to monitor their sleep, and how it might be affected by lifestyle changes. The results are reported in the Proceedings of the National Academy of Sciences (PNAS).

Sleep is vital for human health, yet more than 60% of adults experience poor sleep quality, leading to the loss of between 44 and 54 annual working days, and an estimated one percent reduction in global GDP. Sleep behaviours such as mouth breathing, sleep apnoea and snoring are major contributors to poor sleep quality, and can lead to chronic conditions such as cardiovascular disease, diabetes and depression.

“Poor sleep has huge effects on our physical and mental health, which is why proper sleep monitoring is vital,” said Professor Luigi Occhipinti from the Cambridge Graphene Centre, who led the research. “However, the current gold standard for sleep monitoring, polysomnography or PSG, is expensive, complicated and isn’t suitable for long-term use at home.”

Home devices that are simpler than PSG, such as home sleep tests, typically focus on a single condition and are bulky or uncomfortable. Wearable devices such as smartwatches, while more comfortable to wear, can only infer sleep quality, and are not effective for accurately monitoring disordered sleep.

“We need something that is comfortable and easy to use every night, but is accurate enough to provide meaningful information about sleep quality,” said Occhipinti.

To develop the smart pyjamas, Occhipinti and his colleagues built on their earlier work on a smart choker for people with speech impairments. The team re-designed the graphene-based sensors for breath analysis during sleep, and made several design improvements to increase sensitivity.

“Thanks to the design changes we made, the sensors are able to detect different sleep states, while ignoring regular tossing and turning,” said Occhinpinti. “The improved sensitivity also means that the smart garment does not need to be worn tightly around the neck, which many people would find uncomfortable. As long as the sensors are in contact with the skin, they provide highly accurate readings.”

The researchers designed a machine learning model, called SleepNet, that uses the signals captured by the sensors to identify sleep states including nasal breathing, mouth breathing, snoring, teeth grinding, central sleep apnoea (CSA), and obstructive sleep apnoea (OSA). SleepNet is a ‘lightweight’ AI network, that reduces computational complexity to the point where it can be run on portable devices, without the need to connect to computers or servers.

“We pruned the AI model to the point where we could get the lowest computational cost with the highest degree of accuracy,” said Occhinpinti. “This way we are able to embed the main data processors in the sensors directly.”

The smart pyjamas were tested on healthy patients and those with sleep apnoea, and were able to detect a range of sleep states with an accuracy of 98.6%. By treating the smart pyjamas with a special starching step, they were able to improve the durability of the sensors so they can be run through a regular washing machine.

The most recent version of the smart pyjamas are also capable of wireless data transfer, meaning the sleep data can be securely transferred to a smartphone or computer.

“Sleep is so important to health, and reliable sleep monitoring can be key in preventative care,” said Occhipinti. “Since this garment can be used at home, rather than in a hospital or clinic, it can alert users to changes in their sleep that they can then discuss with their doctor. Sleep behaviours such as nasal versus mouth breathing are not typically picked up in an NHS sleep analysis, but it can be an indicator of disordered sleep.”

The researchers are hoping to adapt the sensors for a range of health conditions or home uses, such as baby monitoring, and have been in discussions with different patient groups. They are also working to improve the durability of the sensors for long-term use.

The research was supported in part by the EU Graphene Flagship, Haleon, and the Engineering and Physical Sciences Research Council (EPSRC), part of UK Research and Innovation (UKRI).

Reference:
Chenyu Tang, Wentian Yi et al. ‘A deep learning-enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life.’ PNAS (2025). DOI: 10.1073/pnas.2420498122

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Researchers call on the international community to recognise and start tackling the ‘biodiversity leak’.

Areas of much greater importance for nature are likely to pay the price for conservation efforts in wealthy nations unless we work to fix this leakAndrew Balmford

Some efforts to preserve or rewild natural habitats are shifting harmful land use to other parts of the world – and this could drive an even steeper decline in the planet’s species, according to a team of conservation scientists and economists led by the University of Cambridge.

Researchers from over a dozen institutions worldwide have come together to call on the global community to acknowledge the ‘biodiversity leak’: the displacement of nature-damaging human activities caused by ringfencing certain areas for protection or restoration.

They argue that rewilding productive farmland or forestry in industrialised nations that have low levels of biodiversity may do more harm than good on a planetary scale.

Exploratory analysis by the team suggests that reclaiming typical UK cropland for nature may be five times more damaging for global biodiversity than the benefit it provides local species, due to the displacement of production to more biodiverse regions.

While this ‘leakage’ has been known about for decades, it is largely neglected in biodiversity conservation, say the researchers. They argue it undermines actions ranging from establishing new nature reserves to the EU’s environmental policies.

Writing in the journal Science, the experts point out that even the UN’s landmark Global Biodiversity Framework – aiming for 30% of the world’s land and seas to be conserved – makes no mention of the leakage problem.

“As nations in temperate regions such as Europe conserve more land, the resulting shortfalls in food and wood production will have to be made up somewhere,” said Professor Andrew Balmford, from the University of Cambridge’s Department of Zoology. 

“Much of this is likely to happen in more biodiverse but often less well-regulated parts of the world, such as Africa and South America. Areas of much greater importance for nature are likely to pay the price for conservation efforts in wealthy nations unless we work to fix this leak.”

“The first thing we need to do is collectively acknowledge that these leaks exist,” said co-author Professor Brendan Fisher from the University of Vermont. “If protesting a logging concession in the USA increases demand for pulp from the tropics, then we are unlikely to be helping biodiversity.”

Co-author Dr Ben Balmford of the University of Exeter said: “This issue demands far greater attention from a sector that seeks to shape how 30% of an ever hungrier and more connected planet is managed.”

‘Leakage’ is already a major issue for carbon credits tied to forest preservation, say researchers. But they argue it’s a real problem for biodiversity conservation efforts too.

While protected areas can slow deforestation inside their borders, there’s evidence it can simply shift to neighbouring areas. Production can also be displaced much further. Efforts to protect the Pacific Northwest’s old-growth forests resulted in increased logging in other North American regions, for example.

Yet a survey of site managers of tropical conservation projects conducted by the Cambridge team found that 37% had not come across the concept of leakage, and less than half of the projects were attempting to curb any displacement damage.*

The researchers explored how leakage caused by protected areas could affect global biodiversity by applying real-world food and biodiversity data to two hypothetical conservation projects.

They found that rewilding a sizeable area of Brazilian soybean farms would push production to nations such as Argentina and USA, but because Brazil is so important for biodiversity, the local conservation gains could be around five times greater than the displacement harms.

The opposite would be true if the equivalent area of UK arable farmland was reclaimed for nature. Here, production would be displaced to Australia, Germany, Italy and Ukraine.**

As the UK has fewer species than these other countries, damage from ‘leakage’ could be five times greater than the local benefit to British biodiversity. 

The experts offer a number of ways to help plug the biodiversity leak. They call on governments and the conservation sector to take leakage far more seriously when making environmental policy at national and global level.

They also point out that leakage could be reduced if conservation projects work with others to reduce demand – especially for high-footprint commodities such as red meat.

There’s scope to limit leakage by targeting conservation to areas high in biodiversity but where current or potential production of food or timber is limited, say researchers. One example is restoring abandoned tropical shrimp farms to mangroves.

However, we should also be much more cautious about restoring natural habitats on currently productive farmland in less biodiverse parts of the world, they argue.

Beyond planning where to conserve, major conservation initiatives should work with partners in other sectors to support local farmers, so that overall levels of production are maintained in the region despite protected areas. The team cite examples ranging from forest-friendly chocolate to herding practices that protect snow leopards.

Where local yield increases are difficult, larger-scale programmes could establish long-range partnerships with suppliers in the same markets to make up shortfalls in production.

“Without attention and action, there is a real risk that the biodiversity leak will undermine hard-won conservation victories,” said co-author Dr Fiona Sanderson of the Royal Society for Protection of Birds, who works on reducing the impacts of cocoa production in Sierra Leone.

Lead author from Cambridge, Prof Andrew Balmford, added: “At its worst, we could see some conservation actions cause net global harm by displacing production to regions which are much more significant for biodiversity.” 

*Survey of 100 practitioners involved in area-based tropical conservation projects, including directors, managers, coordinators, and researchers. Respondents came from 36 countries across all five continents. Further details: https://zenodo.org/records/14780198

** Two hypothetical habitat restoration programmes covering 1000km2 of Brazilian soy-producing land, and restoring 1000km2 of arable farmland in the UK that produces wheat, barley and oilseed rape.

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Researchers have developed a reactor that pulls carbon dioxide directly from the air and converts it into sustainable fuel, using sunlight as the power source.

We can build a circular, sustainable economy – if we have the political will to do itErwin Reisner

The researchers, from the University of Cambridge, say their solar-powered reactor could be used to make fuel to power cars and planes, or the many chemicals and pharmaceuticals products we rely on. It could also be used to generate fuel in remote or off-grid locations.

Unlike most carbon capture technologies, the reactor developed by the Cambridge researchers does not require fossil-fuel-based power, or the transport and storage of carbon dioxide, but instead converts atmospheric CO2 into something useful using sunlight. The results are reported in the journal Nature Energy.

Carbon Capture and Storage (CCS) has been touted as a possible solution to the climate crisis, and has recently received £22bn in funding from the UK government. However, CCS is energy-intensive and there are concerns about the long-term safety of storing pressurised CO2 deep underground, although safety studies are currently being carried out.

“Aside from the expense and the energy intensity, CCS provides an excuse to carry on burning fossil fuels, which is what caused the climate crisis in the first place,” said Professor Erwin Reisner, who led the research. “CCS is also a non-circular process, since the pressurised CO2 is, at best, stored underground indefinitely, where it’s of no use to anyone.”

“What if instead of pumping the carbon dioxide underground, we made something useful from it?” said first author Dr Sayan Kar from Cambridge’s Yusuf Hamied Department of Chemistry. “CO2 is a harmful greenhouse gas, but it can also be turned into useful chemicals without contributing to global warming.”

The focus of Reisner’s research group is the development of devices that convert waste, water and air into practical fuels and chemicals. These devices take their inspiration from photosynthesis: the process by which plants convert sunlight into food. The devices don’t use any outside power: no cables, no batteries – all they need is the power of the sun.

The team’s newest system takes CO2 directly from the air and converts it into syngas: a key intermediate in the production of many chemicals and pharmaceuticals. The researchers say their approach, which does not require any transportation or storage, is much easier to scale up than earlier solar-powered devices.

The device, a solar-powered flow reactor, uses specialised filters to grab CO2 from the air at night, like how a sponge soaks up water. When the sun comes out, the sunlight heats up the captured CO2, absorbing infrared radiation and a semiconductor powder absorbs the ultraviolet radiation to start a chemical reaction that converts the captured CO2 into solar syngas. A mirror on the reactor concentrates the sunlight, making the process more efficient.

The researchers are currently working on converting the solar syngas into liquid fuels, which could be used to power cars, planes and more – without adding more CO2 to the atmosphere.

“If we made these devices at scale, they could solve two problems at once: removing CO2 from the atmosphere and creating a clean alternative to fossil fuels,” said Kar. “CO2 is seen as a harmful waste product, but it is also an opportunity.”

The researchers say that a particularly promising opportunity is in the chemical and pharmaceutical sector, where syngas can be converted into many of the products we rely on every day, without contributing to climate change. They are building a larger scale version of the reactor and hope to begin tests in the spring.

If scaled up, the researchers say their reactor could be used in a decentralised way, so that individuals could theoretically generate their own fuel, which would be useful in remote or off-grid locations.

“Instead of continuing to dig up and burn fossil fuels to produce the products we have come to rely on, we can get all the CO2 we need directly from the air and reuse it,” said Reisner. “We can build a circular, sustainable economy – if we have the political will to do it.”

The technology is being commercialised with the support of Cambridge Enterprise, the University’s commercialisation arm. The research was supported in part by UK Research and Innovation (UKRI), the European Research Council, the Royal Academy of Engineering, and the Cambridge Trust. Erwin Reisner is a Fellow of St John’s College, Cambridge.

Reference:
Sayan Kar et al. ‘Direct air capture of CO2 for solar fuels production in flow.’ Nature Energy (2025). DOI: 10.1038/s41560-025-01714-y

For more information on energy-related research in Cambridge, please visit the Energy IRC, which brings together Cambridge’s research knowledge and expertise, in collaboration with global partners, to create solutions for a sustainable and resilient energy landscape for generations to come. 

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Scientists have created the most detailed map to date of the human hypothalamus, a crucial brain region that regulates body weight, appetite, sleep, and stress.

HYPOMAP confirms the critical role of the hypothalamus in body-weight regulation and has already allowed us to identify new genes linked to obesityGiles Yeo

Published today in Nature, this comprehensive resource, called HYPOMAP, provides an unparalleled view of the brain’s appetite centre and promises to accelerate the development of treatments for obesity and diabetes.

The hypothalamus is often described as the brain’s ‘control centre’, orchestrating many of the body’s most vital processes. While much of our knowledge of the hypothalamus comes from animal studies, especially in mice, translating these findings to humans has long been a challenge. HYPOMAP bridges this gap by providing an atlas of the individual cells within the human hypothalamus. This resource not only charts over 450 unique cell types but also highlights key differences between the human and mouse hypothalamus — differences that have major implications for drug development.

“This is a game-changer for understanding the human hypothalamus,” said Professor Giles Yeo, senior author of the study from the Institute of Metabolic Science-Metabolic Research Laboratories (IMS-MRL) and MRC Metabolic Diseases Unit, University of Cambridge.

“HYPOMAP confirms the critical role of the hypothalamus in body-weight regulation and has already allowed us to identify new genes linked to obesity. It gives us a roadmap to develop more effective, human-specific therapies.”

Together with researchers at the Max Planck Institute for Metabolism Research in Cologne, Professor Yeo and colleagues used cutting-edge technologies to analyse over 400,000 cells from 18 human donors. HYPOMAP allows researchers to pinpoint specific cell types, understand their genetic profiles, and explore how they interact with neighbouring cells. This detailed cellular resolution offers invaluable insights into the circuits that regulate appetite and energy balance, as well as other functions such as sleep and stress responses.

Comparison with a mouse hypothalamus atlas revealed both similarities and critical differences. Notably, some neurons in the mouse hypothalamus have receptors for GLP-1 — targets of popular weight-loss drugs like semaglutide — that are absent in humans.

“While drugs like semaglutide have shown success in treating obesity, newer therapies target multiple receptors such as GLP-1R and GIPR. Understanding how these receptors function specifically in the human hypothalamus is now crucial for designing safer and more effective treatments,” said Dr Georgina Dowsett from the Max Planck Institute for Metabolism Research and formerly at the IMS-MRL.

“Our map of the human hypothalamus is an essential tool for basic and translational research,” added Professor Jens C. Brüning, Director at the Max Planck Institute. “It allows us to pinpoint which mouse nerve cells are most comparable to human cells, enabling more targeted preclinical studies.”

HYPOMAP’s open-access nature ensures that it will be an invaluable resource for scientists worldwide. By offering insights into the hypothalamus’s role in conditions ranging from obesity to cachexia (a wasting condition associated with several illness, which involves extreme loss of muscle and fat), it provides a foundation for tackling some of the most pressing health challenges of our time.

Dr John Tadross, Consultant Pathologist at Addenbrooke’s Hospital and lead author from IMS-MRL, said: “This is just the beginning. The atlas itself is a milestone, but what could really make a difference for patients is understanding how the hypothalamus changes in people who are overweight or underweight. This could fundamentally shift our approach to metabolic health and enable more personalised therapies.”

With HYPOMAP, researchers have a new tool to unlock the secrets of the human brain’s metabolic control centre. By better understanding the human hypothalamus, science takes a significant step toward combating obesity, diabetes, and related conditions.

Reference
Tadross, JA, Steuernagel, L & Dowsett, GKC et al. A comprehensive spatio-cellular map of the human hypothalamus. Nature; 5 Feb 2025; DOI: 10.1038/s41586-024-08504-8

Adapted from a story by the Institute of Metabolic Science-Metabolic Research Laboratories and the Max Planck Institute for Metabolism Research

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From helping to inoculate the public against misinformation to tackling air pollution in rapidly urbanising African cities, researchers from across the University of Cambridge were honoured at the Cambridge Awards on 3 February.

The Cambridge Awards for Research Impact and Engagement, formerly the Vice-Chancellor’s Award, are held annually to recognise exceptional achievement, innovation, and creativity in developing research engagement and impact plans with significant economic, social, and cultural potential. Awarded in 3 categories, the winners for 2024 are:

Established Academic

Winner: Professor Sander van der Linden (Department of Psychology, School of Biological Sciences and Churchill College) and his team at the Cambridge Social Decision-Making Lab (Team application)

Project: A psychological vaccine against misinformation

Professor Sander van der Linden and team have developed a novel approach to countering the spread of harmful misinformation. This ‘psychological vaccine’ resulted in award-winning public impact tools that have shown millions of people how to spot fake news online. These games have been adopted by the World Health Organization, United Nations, UK Government and Google, and led to key policy changes in the EU Digital Services Act.

Early Career Researcher

Winner: Dr Gabriel Okello (Cambridge Institute for Sustainability Leadership, School of Technology)

Project: Applying multidisciplinary, collaborative approaches to tackle air pollution in rapidly urbanising African cities

The project catalysed Uganda’s first-ever air quality standards, advancing policy and public health. It drove transformative growth in the e-mobility sector and battery-swapping stations. The Clean Air Network was established as a multi-regional community of practice for air quality management across Africa. The platform now provides real-time air quality data enabling evidence-based decision-making in Uganda and 8 other African countries.

Collaboration Award

Winner: 

Lead: Professor Paul Fletcher (Department of Psychiatry, School of Clinical Medicine, Clare College), Dr Dervila Glynn (Cambridge Neuroscience IRC), Dominic Matthews (Ninja Theory Ltd), Sharon Gilfoyle (Cambridgeshire and Peterborough NHS Foundation Trust)

Project: Representing psychosis in video games: communicating clinical science and tackling stigma

This work draws together expertise in video game design and clinical neuroscience, with lived experience of mental illness to co-produce two award-winning video games vividly conveying the nature of altered experience of reality in a character with psychosis. Within conversations around mental health, psychosis is neglected and highly stigmatised.

In creating a powerful character and telling her story through gameplay, the project has enabled sensitive and thoughtful conversations about psychosis, and mental illness in general. It has had a measurably positive impact on stigma.

More about the Cambridge Awards for Research Impact and Engagement

Find out more about the winning projects and meet our runners-up. 

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The University welcomed the Chancellor of the Duchy of Lancaster, Rt Hon Pat McFadden MP, to tour the DAWN supercomputer and discuss the ways in which AI can transform public services and healthcare.  

From improving diagnostics to speeding up planning applications, Cambridge AI research is producing positive impact in people’s lives.Vice-Chancellor, Professor Deborah Prentice

Mr McFadden was welcomed by Vice-Chancellor, Professor Deborah Prentice, to DAWN, the fastest supercomputer in Europe, where he was given a tour of the cutting-edge facility by Dr Paul Calleja, Director of the University’s Research Computing Services. He also spoke with engineers who work on the supercomputer, with industry partners at Dell, and the UK’s Atomic Energy Authority. 

Professor Prentice said: “I was very pleased to welcome the Minister to Cambridge to explore the rapidly-developing ways in which the University’s research, and DAWN-powered AI, are driving improvements in everyday life. From improving diagnostics to speeding up planning applications, Cambridge AI research is producing positive impact in people’s lives.”

Following the tour of DAWN, the Minister visited Cambridge University Hospitals (CUH) to witness firsthand the practical applications of DAWN-powered AI. Mr McFadden was shown two use cases of this technology in healthcare. 

Professor Fleur Kilburn-Toppin discussed the potential for AI in breast cancer diagnosis through the EDITH trial, a multicentre mammography study assessing AI’s role in enhancing cancer detection. This discussion coincided with the Government’s launch of the EDITH trial to tackle breast cancer on World Cancer Day. 

The second case study was presented in the Department of Radiology, by Dr Suthesh Sivapalaratnam and Professor Carola-Bibiane Schönlieb, who spoke to the Minister about the Blood Counts AI project which harnesses AI to revolutionise disease detection. The project provides an early warning system for infectious diseases, improving public health responses across the NHS. 

The day concluded with a roundtable conversation with academics and clinicians around how the UK can harness the potential of AI to improve public services across various areas, ranging from healthcare to productivity and local government services.  

This visit underscored the University’s pivotal role in harnessing AI for societal benefit and the potential for University research in cutting-edge technology to help public service transformation. 

Mr McFadden said: “AI has the power to transform our public services, and the DAWN supercomputer is an excellent example of cutting-edge work being done right here in the UK, with an amazing partnership between Cambridge University and Addenbrooke’s Hospital, improving medical diagnosis for patients.

“What’s happening in Cambridge is really exciting, but we are only at the foothills of this technology and its potential to improve people’s lives. Which is why we are putting innovation at the forefront of our Plan for Change.”

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National targets for solar and wind power will see reliance on natural gas plummet, reducing electricity price volatility across Europe, with major beneficiaries including the UK and Ireland, the Nordics, and the Netherlands.

The UK in particular is projected to see major benefits to its energy market stability from renewablesLaura Diaz Anadon

Hitting the current national 2030 quotas for solar and wind energy could reduce the volatility of electricity markets by an average of 20% across 29 European countries, according to a new study from the University of Cambridge.  

The intensity of spikes in power prices are predicted to fall in every country by the end of the decade if commitments to green energy are met, as natural gas dependency is cut.   

The UK and Ireland would be the biggest beneficiaries, with 44% and 43% reductions in the severity of electricity price spikes by 2030, compared with last year.

Germany could experience a 31% decline in electricity price volatility, with the Netherlands and Belgium seeing price spikes ease by 38% and 33% respectively.

The simulations conducted for the new study show that scaling up renewable energy minimises the market impact of fluctuations in natural gas price – increasing stability even when considering the reliance of renewable technologies on weather.

Some EU leaders and energy ministers have called for renewables targets on grounds of energy security as well as decarbonisation, particularly since Putin’s war on Ukraine stemmed the flow of Russian gas.

The study, published in the journal Nature Energy, calculates in detail how such aims would affect the volatility of wholesale electricity prices in energy markets across Europe.

“The volatility of energy prices is a major cause of damage to national economies,” said Laura Diaz Anadon, the University of Cambridge’s Professor of Climate Change Policy.

“Consumers are still reeling from sharp increases in electricity prices brought about by natural gas shortages following Russia’s invasion of Ukraine,” said Anadon. “We show that hitting renewables targets reduce the likelihood of such price spikes in the future.”

Daniel Navia, a researcher with the University’s Centre for Environment, Energy and Natural Resource Governance (CEENRG), said: “Meeting renewable energy targets is not only good for carbon neutrality, but we can see it is a boost to economic resilience”

“We had probably underestimated how costly energy price shocks are to our societies, and the last crisis has been a stark reminder.”

The Cambridge researchers used the University’s high performance computing facilities to model a wide range of factors – from fluctuations in weather patterns and energy demands to fuel capacity – to map the current and future grids of all 27 EU nations plus the UK and Switzerland.

They assessed electricity markets in 2030 based on the commitments to renewables as stated in each nation’s national energy and climate plan.

“The UK in particular is projected to see major benefits to its energy market stability from renewables,” said Anadon.

“The UK has struggled with its exposure to gas prices due to a lack of energy storage and limited connections to the European grid. This has led to more hours where electricity prices are set by natural gas.”

The research also suggests that wholesale prices of electricity could fall by over a quarter on average across all countries in the study by decade’s end if they stick to current national renewables targets.

Again, populations in the UK and Ireland stand to gain significantly, with electricity prices predicted to fall by around 45% by 2030, compared with the current situation.

Several of the Nordic nations could see over 60% reductions in electricity costs by 2030, while in Germany the price is predicted to fall by 34%, with Belgium seeing a similar drop of 31%. The study suggests the Netherlands could see the price of electricity fall by 41%.

While the study’s authors caution that trends in electricity prices depend on factors that are “impossible to predict”, they say their results are in line with recent outputs by institutions such as the International Energy Agency.

In fact, Navia and Anadon say their modelling may even underestimate the potential for electricity price stability across Europe, as the projections were calculated using data from 1990-2021 – before the energy crisis created by Russia’s attack on Ukraine.

“It makes sense to think about renewables as a security investment, and if we lose the momentum towards green energy, we are clearly harming the climate, but we also exposing ourselves to unknowable risks down the line,” said Anadon.  

The new study also charts the effects on electricity prices if countries overshoot on renewables. If Europe exceeds its renewable energy goals by 30%, electricity prices could become 50% less sensitive to natural gas, compared to just meeting renewables targets.

However, the study suggests there are tipping points where renewables cause the price of power to fall so far that it stops providing sufficient return on investment, and the green energy industries may stall. 

Added Navia: “If we are to fully utilise solar and wind as a security tool, Europe might have to rethink how its energy markets are designed, and what incentives it can offer the private sector to maintain the societal insurance value it gets from renewable energy.”

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Tiny copper ‘nano-flowers’ have been attached to an artificial leaf to produce clean fuels and chemicals that are the backbone of modern energy and manufacturing.

The researchers, from the University of Cambridge and the University of California, Berkeley, developed a practical way to make hydrocarbons – molecules made of carbon and hydrogen – powered solely by the sun.

The device they developed combines a light absorbing ‘leaf’ made from a high-efficiency solar cell material called perovskite, with a copper nanoflower catalyst, to convert carbon dioxide into useful molecules. Unlike most metal catalysts, which can only convert CO₂ into single-carbon molecules, the copper flowers enable the formation of more complex hydrocarbons with two carbon atoms, such as ethane and ethylene — key building blocks for liquid fuels, chemicals and plastics.

Almost all hydrocarbons currently stem from fossil fuels, but the method developed by the Cambridge-Berkeley team results in clean chemicals and fuels made from CO2, water and glycerol – a common organic compound – without any additional carbon emissions. The results are reported in the journal Nature Catalysis.

The study builds on the team’s earlier work on artificial leaves, which take their inspiration from photosynthesis: the process by which plants convert sunlight into food. “We wanted to go beyond basic carbon dioxide reduction and produce more complex hydrocarbons, but that requires significantly more energy,” said Dr Virgil Andrei from Cambridge’s Yusuf Hamied Department of Chemistry, the study’s lead author.

Andrei, a Research Fellow of St John’s College, Cambridge, carried out the work as part of the Winton Cambridge-Kavli ENSI Exchange programme in the lab of Professor Peidong Yang at University of California, Berkeley.

By coupling a perovskite light absorber with the copper nanoflower catalyst, the team was able to produce more complex hydrocarbons. To further improve efficiency and overcome the energy limits of splitting water, the team added silicon nanowire electrodes that can oxidise glycerol instead. This new platform produces hydrocarbons much more effectively — 200 times better than earlier systems for splitting water and carbon dioxide.

The reaction not only boosts CO₂ reduction performance, but also produces high-value chemicals such as glycerate, lactate, and formate, which have applications in pharmaceuticals, cosmetics, and chemical synthesis.

“Glycerol is typically considered waste, but here it plays a crucial role in improving the reaction rate,” said Andrei. “This demonstrates we can apply our platform to a wide range of chemical processes beyond just waste conversion. By carefully designing the catalyst’s surface area, we can influence what products we generate, making the process more selective.”

While current CO₂-to-hydrocarbon selectivity remains around 10%, the researchers are optimistic about improving catalyst design to increase efficiency. The team envisions applying their platform to even more complex organic reactions, opening doors for innovation in sustainable chemical production. With continued improvements, this research could accelerate the transition to a circular, carbon-neutral economy.

“This project is an excellent example of how global research partnerships can lead to impactful scientific advancements,” said Andrei. “By combining expertise from Cambridge and Berkeley, we’ve developed a system that may reshape the way we produce fuels and valuable chemicals sustainably.”

The research was supported in part by the Winton Programme for the Physics of Sustainability, St John’s College, the US Department of Energy, the European Research Council, and UK Research and Innovation (UKRI).

Reference:
Virgil Andrei et al. ‘Perovskite-driven solar C2 hydrocarbon synthesis from CO2.’ Nature Catalysis (2025). DOI: 10.1038/s41929-025-01292-y

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A 13^th-century fresco rediscovered in Ferrara, Italy, puts Islamic art at the heart of medieval Christianity

The 700-year-old fresco is thought to be the only surviving image of its kind, offering precious evidence of a little-known Christian practice.

The partially-visible fresco, identified by Cambridge historian Dr Federica Gigante, almost certainly depicts a real tent, now lost, which the artist may have seen in the same church.

The brightly coloured original tent, covered in jewels, could have been a diplomatic gift from a Muslim leader or a trophy seized from the battlefield.

Gigante’s research, published in The Burlington Magazine, also suggests that a high-profile figure such as Pope Innocent IV – who gifted several precious textiles to the Benedictine convent church of S. Antonio in Polesine, Ferrara, where the fresco was painted – may have given such a tent.

“At first, it seemed unbelievable and just too exciting that this could be an Islamic tent,” said Dr Gigante.

“I quickly dismissed the idea and only went back to it years later with more experience and a braver attitude to research. We probably won’t find another such surviving image. I haven’t stopped looking but my guess is that it is fairly unique.”

The fresco provides crucial evidence of a medieval church using Islamic tents in key Christian practices, including mass, the study suggests.

“Islamic textiles were associated with the Holy Land from where pilgrims and crusaders brought back the most precious such Islamic textiles,” Gigante said.

“They thought there existed artistic continuity from the time of Christ so their use in a Christian context was more than justified. Christians in medieval Europe admired Islamic art without fully realising it.”

While it is well known that Islamic textiles were present in late medieval European churches, surviving fragments are usually found wrapped around relics or in the burials of important people.

Depictions of Islamic textiles survive, in traces, on some church walls in Italy as well as in Italian paintings of the late medieval period. But images of Islamic tents from the Western Islamic world, such as Spain, are extremely rare and this might be the only detailed, full-size depiction to be identified.

The fresco was painted between the late 13^th and early 14^th centuries to represent a canopy placed over the high altar. The artist transformed the apse into a tent comprising a blue and golden drapery wrapped around the three walls and topped by a double-tier bejewelled conical canopy of the type found throughout the Islamic world.

“The artist put a lot of effort into making the textile appear life-like,” Gigante said.

The background was a blue sky covered in stars and birds, giving the impression of a tent erected out in the open.

In the early 15^th century, the fresco was partly painted over with scenes from the lives of the Virgin Mary and Jesus Christ. This later fresco has captured the attention of art historians who have overlooked the sections of older fresco.

Gigante identified the depiction of Islamic textiles when she visited the church ten years ago but it took further research to prove that the fresco represents an Islamic tent.

A real altar-tent

Gigante argues that the fresco depicts an Islamic tent which actually existed and that at some point in the 13^th century, may even have been physically present in the convent church, providing a direct reference point for the artist.

It is already known that medieval churches used precious textile hangings to conceal the altar from view either permanently, during Mass or for specific liturgical periods. And when studying the fresco, Gigante noticed that it depicts the corner of a veil, painted as if drawn in front of the altar. Gigante, therefore, believes that the real tent was adapted to serve as a ‘tetravela’, altar-curtains.

“If the real tent was only erected in the church on certain occasions, the fresco could have served as a visual reminder of its splendour when it was not in place,” Gigante said.

“The interplay between painted and actual textiles can be found throughout Europe and the Islamic world in the late medieval period.”

Gigante’s study notes that the walls of the apse are studded with nails and brackets, and that they could have served as structural supports for a hanging textile.

Gigante points to the fresco’s ‘extraordinarily precise details’ as further evidence that it depicts a real tent. The fabric shown in the fresco features blue eight-pointed star motifs inscribed in roundels, the centre of which was originally picked out in gold leaf, exactly like the golden fabrics used for such precious Islamic tents.

A band with pseudo-Arabic inscriptions runs along the edge of both the top and bottom border. The textile also features white contours to emphasise contrasting colours reflecting a trend in 13^th-century Andalusi silk design.

The structure, design and colour scheme of the tent closely resemble the few surviving depictions of Andalusi tents, including in the 13^th-century manuscript, the Cantigas de Santa Maria. They also match one of the few potential surviving Andalusi tent fragments, the ‘Fermo chasuble’, which is said to have belonged to St Thomas Becket, Archbishop of Canterbury.

Gigante also compares the jewels depicted in the fresco with a rare surviving jewelled textile made by Arab craftsmen, the mantle of the Norman King Roger II of Sicily (1095–1154), which was embroidered with gold and applied with pearls, gemstones and cloisonné enamel.

Spoils of war

In the 13^th century, it was common for banners and other spoils of war to be displayed around church altars in Europe.

“Tents, especially Islamic royal tents were among the most prized gifts in diplomatic exchanges, the most prominent royal insignia on campsites and the most sought-after spoils on battlefields,” Gigante said.

“Tents made their way into Europe as booty. During anti-Muslim expeditions, it was common to pay mercenaries in textiles and a tent was the ultimate prize.

“The fresco matches descriptions of royal Islamic tents which were seized during the wars of Christian expansion into al-Andalus in the 13th century.”

Gift from a Pope?

From the 9^th century, Popes often donated Tetravela (altar-curtains) to churches and papal records reveal that by 1255, Pope Innocent IV had sent ‘draperies of the finest silk and gold fabrics’ to the convent of S. Antonio in Polesine.

“We can’t be certain but it is possible that a person of high-profile such as Pope Innocent IV gifted the tent,” Gigante says.

An Andalusi tent taken from the campsite of the Almohad caliph Muhammad al-Nāsir was sent to Pope Innocent III after 1212 meaning that there was an Islamic tent in St Peter’s Basilica at some point prior to the painting of the fresco.

Gigante suggests that the tent could also have been part of a diplomatic gift made to the powerful Este family which brokered alliances between the Guelfs and Ghibellins, factions supporting the Pope and the Holy Roman Emperor respectively. The convent was founded in 1249 by Beatrice II d’Este.

“Many people don’t realize how extraordinarily advanced and admired Islamic culture was in the medieval period,” Gigante said.

Last year Dr Gigante identified the Verona Astrolabe, an eleventh-century Islamic astrolabe bearing both Arabic and Hebrew inscriptions.

Federica Gigante is a Research Associate at the University of Cambridge’s Faculty of History and the Hanna Kiel Fellow at I Tatti, the Harvard University Center for Italian Renaissance Studies.

Reference

F. Gigante, ‘An Islamic tent in S. Antonio in Polesine, Ferrara’, The Burlington Magazine (2025).

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Published 1st February 2025

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Image credits

_{Federica Gigante: Fresco images
Yale University Art Gallery: Pope Innocent IV
Istanbul University Library: Persian ambassador presenting tent, from MS FY 1404 Istanbul, fol.43b
Geobia: Church of S. Antonio exterior (under a CC license via Wikipedia)}

The University of Cambridge has been named as the leading UK university in a new report on the top 50 universities powering global innovation.

Cambridge has a thriving community of spin-outs, start-ups and partnerships that demonstrates how academia and industry can work together to transform ideas into real-world impactDeborah Prentice

The report, carried out by analytics firm Clarivate, looks at the critical role of research in shaping global industrial innovation and societal impact, using data and expert insights derived from academic research and patent citations.

The report highlights how knowledge flows between academia and industry across countries and regions, underscoring the global nature of innovation. It identifies the top 50 universities named on the academic papers that received the highest number of citations from patents granted to the companies and organisations on the Top 100 Global Innovators 2024 list.

Professor Deborah Prentice, Vice-Chancellor, University of Cambridge, said: “Cambridge has a thriving community of spin-outs, start-ups and partnerships that demonstrates how academia and industry can work together to transform ideas into real-world impact. The University is key to this, and we are developing hugely ambitious plans that will transform the UK economy and reinforce the UK’s status as a leader in global innovation.”

The report comes the day after Chancellor of the Exchequer Rachel Reeves unveiled her strategy to unleash the potential of the Oxford-Cambridge Growth Corridor by catalysing the growth of UK science and technology. The plan recognises the University of Cambridge as the world’s leading science and technological cluster by intensity, and its potential to rapidly build on the £30bn contribution it already makes to the UK economy.

According to the report, the top 10 universities influencing patented inventions are: 

1. Harvard University (US)
2. Stanford University (US)
3. Massachusetts Institute of Technology – MIT (US)
4. University of California, Berkeley (US)
5. Université Paris Cité (France)
6. University of Cambridge (UK)
7. University of Washington, Seattle (US)
8. University of California, San Diego (US)
9. University of Michigan (US)
10. University of Toronto (Canada)

Among the report’s key findings was that the UK demonstrates particularly diverse international influence, with its research often serving as a bridge across regions.

Gordon Rogers, report author and Senior Manager, Data Science at the Institute for Scientific Information at Clarivate, said: “Groundbreaking ideas driving the world’s most innovative companies often originate from academic research. Our report demonstrates that by fostering collaboration between academia and industry, we can fuel technological advancements, providing solutions to societal challenges in healthcare, sustainability, and economic development.”

Read more at: The top 50 universities powering global innovation

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When young adults start working, the amount of daily physical activity they do increases sharply, only to fall away again over the next few years, while the amount of sleep they get falls slightly, according to new research led by scientists at the University of Cambridge.

If we want to stay healthy throughout our lives, we need to remember that keeping active is an important way of helping us achieve this goalAlena Oxenham

The increase in physical activity was mainly seen in those doing semi-routine occupations such as bus driving or hairdressing, and routine occupations such as cleaning or waiting, or technical jobs. There was little change seen among people entering managerial or professional occupations.

People who work from home saw a decrease in levels of physical activity – though their sleep levels did not change when they started work.

Young adulthood – ages 16 to 30 years – is an important time in terms of health. Although we are typically at our peak physical health, it is also a time when many risk factors for long term diseases such as heart disease, type 2 diabetes and cancer begin to develop.

Health guidelines recommend young adults get between seven and nine hours of sleep a night, engage in 150 minutes or more of moderate physical activity per week, and consume at least five portions of fruit and vegetables per day.

Young adulthood is also the time when most people start work, which changes their daily routines and activities, resources such as time and money, and social and physical environments – all of which affect health behaviours and health in later life.

To quantify the impact that starting work has on health-related behaviours, a team led by researchers at the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge examined repeated data taken over time from more than 3,000 participants in the UK Household Longitudinal Study. All the participants were aged 16–30 years and started work for the first time between 2015 and 2023.  

The results are published today in the International Journal of Behavioral Nutrition and Physical Activity.

Dr Eleanor Winpenny, who was based at the University of Cambridge when she carried out the work, but is now at Imperial College London, said: “We know about physical activity and sleep patterns among young people while they’re at school, but very little about what happens when they start work. Given the impact that work can have on our lives – and the lasting impacts this can have on our health – it’s important to try and understand what happens at this transition.”

The analysis showed that when people started work, their physical activity increased by an amount equivalent to around 28 min of moderate activity (such as cycling) per day on average – but then decreased each year after starting work by around 7 min per day.

The biggest increase was among males – up by an equivalent of around 45 min of moderate activity per day compared to an increase of around 16 min for females. People who did not have a university degree also showed a greater increase in physical activity compared to those with a university degree – equivalent to around a 42 min increase of moderate physical activity per day compared to 15 min per day.

Working from home, however, appeared to be associated with an initial decrease in physical activity, equivalent to around 32 min of moderate activity per day.

When young adults started work, the amount of time they slept per night dropped immediately by almost 10 minutes and remained stable at this level over time; however, people without a degree showed a continuing decrease of about 3 minutes of sleep per night each year after starting work, while those with a degree slowly increased back to their pre-work sleep levels.

There was little change in the amount of fruit and vegetables consumed after starting work.

Alena Oxenham, from the MRC Epidemiology Unit, said: “Beginning work can have a profound impact on our lifestyles and on behaviours that might make a difference to our health, if not immediately then later in life.

“Although we found that people tend to do more physical activity when they begin work, which is good news, these are averages, and some people – particularly those who work from home and, to a lesser degree, those with office-based jobs – may do less.

“If we want to stay healthy throughout our lives, we need to remember that keeping active is an important way of helping us achieve this goal. Those working at home might want to consider incorporating physical activity into their day, for example by going for a walk before or after work, or during a lunch break.”

Dr Winpenny added: “Workplaces provide an opportunity to create environments and cultures that support healthier diets, more physical activity and better sleep for young adults. This could result in healthier employees and fewer sick days in the immediate term, but also have long term benefits, helping prevent health issues in later life.”

The research was funded by the MRC and the National Institute for Health and Care Research.

Reference
Oxenham, AF, et al. New job, new habits? A multilevel interrupted time series analysis of changes in diet, physical activity and sleep among young adults starting work for the first time. International Journal of Behavioral Nutrition and Physical Activity; 28 Jan 2025; DOI: 10.1186/s12966-024-01682-8

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Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.

We urgently need new treatments to slow the progress of dementia, if not to prevent it. If we can find drugs that are already licensed for other conditions, then we can get them into trials much faster than we could do for an entirely new drugBen Underwood

The study, led by researchers from the universities of Cambridge and Exeter, identified several drugs already licensed and in use that have the potential to be repurposed to treat dementia.

Dementia is a leading cause of death in the UK and can lead to profound distress in the individual and among those caring for them. It has been estimated to have a worldwide economic cost in excess of US$1 trillion dollars.

Despite intensive efforts, progress in identifying drugs that can slow or even prevent dementia has been disappointing. Until recently, dementia drugs were effective only for symptoms and have a modest effect. Recently, lecanemab and donanemab have been shown to reduce the build-up in the brain of amyloid plaques – a key characteristic of Alzheimer’s disease – and to slow down progression of the disease, but the National Institute for Health and Care Excellence (NICE) concluded that the benefits were insufficient to justify approval for use within the NHS.

Scientists are increasingly turning to existing drugs to see if they may be repurposed to treat dementia. As the safety profile of these drugs is already known, the move to clinical trials can be accelerated significantly.  

Dr Ben Underwood, from the Department of Psychiatry at the University of Cambridge and Cambridgeshire and Peterborough NHS Foundation Trust, said: “We urgently need new treatments to slow the progress of dementia, if not to prevent it. If we can find drugs that are already licensed for other conditions, then we can get them into trials and – crucially – may be able to make them available to patients much, much faster than we could do for an entirely new drug. The fact they are already available is likely to reduce cost and therefore make them more likely to be approved for use in the NHS.”

In a study published today in Alzheimer’s and Dementia: Translational Research & Clinical Interventions, Dr Underwood, together with Dr Ilianna Lourida from the University of Exeter, led a systematic review of existing scientific literature to look for evidence of prescription drugs that altered the risk of dementia. Systematic reviews allow researchers to pool several studies where evidence may be weak, or even contradictory, to arrive at more robust conclusions.

In total, the team examined 14 studies that used large clinical datasets and medical records, capturing data from more than 130 million individuals and 1 million dementia cases. Although they found a lack of consistency between studies in identifying individual drugs that affect the risk of dementia, they identified several drug classes associated with altered risk.

One unexpected finding was an association between antibiotics, antivirals and vaccines, and a reduced risk of dementia. This finding supports the hypothesis that common dementias may be triggered by viral or bacterial infections, and supports recent interest in vaccines, such as the BCG vaccine for tuberculosis, and decreased risk of dementia.

Anti-inflammatory drugs such as ibuprofen were also found to be associated with reduced risk. Inflammation is increasingly being seen to be a significant contributor to a wide range of diseases, and its role in dementia is supported by the fact that some genes that increase the risk of dementia are part of inflammatory pathways.

The team found conflicting evidence for several classes of drugs, with some blood pressure medications and anti-depressants and, to a lesser extent, diabetes medication associated with a decreased risk of dementia and others associated with increased risk.

Dr Ilianna Lourida from the National Institute for Health and Care Research Applied Research Collaboration South West Peninsula (PenARC), University of Exeter, said: “Because a particular drug is associated with an altered risk of dementia, it doesn’t necessarily mean that it causes or indeed helps in dementia. We know that diabetes increases your risk of dementia, for example, so anyone on medication to manage their glucose levels would naturally also be at a higher risk of dementia – but that doesn’t mean the drug increases your risk.

“It’s important to remember that all drugs have benefits and risks. You should never change your medicine without discussing this first with your doctor, and you should speak to them if you have any concerns.”

The conflicting evidence may also reflect differences in how particular studies were conducted and how data was collected, as well as the fact that different medications even within the same class often target different biological mechanisms.

The UK government is supporting the development of an Alzheimer’s trial platform to evaluate drugs rapidly and efficiently, including repurposed drugs currently used for other conditions.

“Pooling these massive health data sets provides one source of evidence which we can use to help us focus on which drugs we should try first,” said Dr Underwood. “We’re hopeful this will mean we can find some much-needed new treatments for dementia and speed up the process of getting them to patients.”

Reference
Underwood, BU & Lourida, I et al. Data-driven discovery of associations between prescribed drugs and dementia risk: A systematic review. Alz & Dem; 21 Jan 2025; DOI: 10.1002/trc2.70037

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The world’s botanic gardens must pull together to protect global plant biodiversity in the face of the extinction crisis, amid restrictions on wild-collecting, say researchers.

A concerted, collaborative effort across the world’s botanic gardens is now needed to conserve a genetically diverse range of plants.Samuel Brockington

A major study of botanic gardens around the world has revealed their struggles with one fundamental aim: to safeguard the world’s most threatened plants from extinction.

Researchers analysed a century’s worth of records – from 1921 to 2021 – from fifty botanic gardens and arboreta currently growing half a million plants, to see how the world’s living plant collections have changed over time. 

The results suggest that the world’s living collections have collectively reached peak capacity, and that restrictions on wild plant collecting around the world are hampering efforts to gather plant diversity on the scale needed to study and protect it.

There is little evidence that institutions are managing to conserve threatened plants within collections, on a global scale, despite accelerating rates of elevated extinction risk.

The findings imply that tackling the loss of biodiversity has not been prioritised across the world’s botanic gardens as a collective – a fact the researchers say must be urgently addressed.

Curator of Cambridge University Botanic Garden Professor Samuel Brockington, who led the work, said: “A concerted, collaborative effort across the world’s botanic gardens is now needed to conserve a genetically diverse range of plants, and to make them available for research and future reintroduction into the wild.”

In their report, published in the journal Nature Ecology and Evolution, the researchers say the Convention on Biological Diversity (CBD) has effectively halved the level at which plants are being collected from the wild, and also created obstacles to the international exchange of plants.

Brockington, who is also Professor of Evolution in the University of Cambridge’s Department of Plant Sciences, said: “The impact of the Convention on Biological Diversity is a remarkable demonstration of the power and value of international agreements. But it seems to be preventing individual botanic gardens from working with many globally threatened plant species that we could help save from extinction.”

Collective thinking

As much as 40% of the world’s plant diversity is at elevated risk of extinction. Acceptance that individual collections have limited capacity to single-handedly prevent species extinction demands a rethink as to how they collaborate to store and safeguard diversity in living collections.

The researchers say it will be vital for the living collections to be considered as a ‘meta-collection’ in future: only by working closely together will the world’s botanic gardens be able to hold the range of plants needed to make a meaningful contribution to conservation efforts. This will include sharing data and expertise and supporting the development of new collections in the global south, where much of the world’s biodiversity is located. 

The researchers point out that some individual institutions, like the Royal Botanic Gardens Edinburgh, have successfully targeted and measurably conserved threatened conifer species. Similarly, Botanic Gardens Conservation International (BGCI) has established numerous global conservation consortia. However, these initiatives are the exception.

Wild decline

Plants must be regularly replaced or propagated within living collections: the average lifetime of a specimen is just 15 years. But the team’s analysis found that the number of wild-origin plants – those collected in the wild – in the collections peaked in 1993 and has been in decline ever since. 

“It is certainly not getting any easier to sustain the diversity of our collections. This is especially true for wild-collected plants, and they’re the most valuable for us in terms for supporting research, and in finding solutions to the twin challenges of climate change and global biodiversity loss,” said Brockington.

Weather worries

As climate change alters growing conditions in different regions of the world, it will become more challenging for individual botanic gardens to continue to grow such a diverse range of species.

Brockington said: “Climate change affects our work directly by altering local weather conditions – we’ve already seen record-breaking temperatures in Cambridge in recent years. That’s going to affect how well our plants survive, so we need to think rationally and collectively about the best locations to hold different species across the global network of living collections.” 

On 25 July 2019, Cambridge University Botanic Garden reached 38.7⁰C – the highest temperature ever recorded in the UK at that time.

Diversity is key

Genetic diversity is important when it comes to protecting plants at risk of extinction, because it allows for breeding populations of species that can adapt to future challenges.

The more individual plants of a particular species in a collection, the greater the genetic diversity is likely to be. 

The team says data from the International Conifer Conservation Programme, run by the Royal Botanic Garden Edinburgh, shows that living collections can make a valuable contribution to conservation efforts – given the right resource and focus. By distributing threatened species across a network of safe sites, the trees are grown where they grow best, and as a whole they represent a strong sample of the genetic diversity of this important group.
Ethical collecting

Last year, Cambridge University Botanic Garden advertised for a new ‘Expedition Botanist’ to lead global plant-collection expeditions and contribute to vital conservation efforts. 

Brockington says these expeditions remain vital to work to safeguard and study the world’s plant species. He suggests that collaborative collecting work is possible, in a fair and ethical way, that builds equitable international partnerships. 

The CBD is a global agreement, signed by 150 government leaders in 1992, dedicated to promoting sustainable development. It makes each country responsible for protecting its own biodiversity, and supports fair and equitable sharing of the benefits arising out of the use of that biodiversity.

There are 3,500 botanic gardens and arboreta worldwide. They exist so that scientists can study, conserve and provide access to the world’s plants, as well as showcasing them to the public.

Botanic Gardens Conservation International (BGCI) is a charity whose purpose is to mobilise botanic gardens and engage partners in securing plant diversity for the wellbeing of people and the planet.

Reference: Cano, A. et al: ‘Insights from a century of data reveal global trends in ex situ living plant collections.’ Nature Ecology and Evolution, January 2024. DOI: 10.1038/s41559-024-02633-z
 

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Cambridge researchers are developing implants that could help repair the brain pathways damaged by Parkinson’s disease.

Our ultimate goal is to create precise brain therapies that can restore normal brain function in people with Parkinson’sGeorge Malliaras

As part of a £69 million funding programme supported by the Advanced Research + Invention Agency (ARIA), Professor George Malliaras from Cambridge’s Department of Engineering will co-lead a project that uses small clusters of brain cells called midbrain organoids to develop a new type of brain implant, which will be tested in animal models of Parkinson’s disease.

The project led by Malliaras and Professor Roger Barker from the Department of Clinical Neurosciences, which involves colleagues from the University of Oxford, the University of Lund and BIOS Health, is one of 18 projects funded by ARIA as part of its Precision Neurotechnologies programme, which is supporting research teams across academia, non-profit R&D organisations, and startups dedicated to advancing brain-computer interface technologies.

The programme will direct £69 million over four years to unlock new methods for interfacing with the human brain at the neural circuit level, to treat many of the most complex neurological and neuropsychiatric disorders, from Alzheimer’s to epilepsy to depression.

By addressing bottlenecks in funding and the lack of precision offered by current approaches, the outputs of this programme will pave the way for addressing a much broader range of conditions than ever before, significantly reducing the social and economic impact of brain disorders across the UK.

Parkinson’s disease occurs when the brain cells that make dopamine (a chemical that helps control movement) die off, causing movement problems and other symptoms. Current treatments, like dopamine-based drugs, work well early on, but can cause serious side effects over time.

In the UK, 130,000 people have Parkinson’s disease, and it costs affected families about £16,000 per year on average – more than £2 billion in the UK annually. As more people age, the number of cases will grow, and new treatments are urgently needed.

One idea is to replace the lost dopamine cells by transplanting new ones into the brain. But these cells need to connect properly to the brain’s network to fix the problem, and current methods don’t fully achieve that.

In the ARIA-funded project, Malliaras and his colleagues are working on a new approach using small clusters of brain cells called midbrain organoids. These will be placed in the right part of the brain in an animal model of Parkinson’s disease. They’ll also use advanced materials and electrical stimulation to help the new cells connect and rebuild the damaged pathways.

“Our ultimate goal is to create precise brain therapies that can restore normal brain function in people with Parkinson’s,” said Malliaras.

“To date, there’s been little serious investment into methodologies that interface precisely with the human brain, beyond ‘brute force’ approaches or highly invasive implants,” said ARIA Programme Director Jacques Carolan. “We’re showing that it’s possible to develop elegant means of understanding, identifying, and treating many of the most complex and devastating brain disorders. Ultimately, this could deliver transformative impact for people with lived experiences of brain disorders.”

Other teams funded by the programme include one at Imperial College London who is developing an entirely new class of biohybridised technology focused on engineering transplanted neurons with bioelectric components. A Glasgow-led team will build advanced neural robots for closed-loop neuromodulation, specifically targeting epilepsy treatment, while London-based Navira will develop a technology for delivering gene therapies across the blood-brain barrier, a crucial step towards developing safer and more effective treatments.

Adapted from an ARIA media release.

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Autistic people in the UK are being invited to participate in a University of Cambridge-led project exploring the uniquely powerful connection between autism and comics.

Too often the question of how to support autistic people is addressed from a deficit perspectiveProf Jenny Gibson

The study will lead to new guidance encouraging both the comics industry and enthusiasts to make comics communities better places for neurodivergent fans and artists. It is being led by academics at the University’s Faculty of Education and will begin this month with an open, online survey aimed at autistic comics fans.

Research by the Comics Cultural Impact Collective (CCIC) – which will also be part of the collaboration – indicates that hundreds of young people self-identifying as neurodivergent are involved in Britain’s comics community, either as fans or creators.

The CCIC also suggests, however, that neurodivergent enthusiasts often find spaces like fan conventions, comic book stores, online communities and the comics industry less than welcoming, and frequently feel ‘siloed’. How to address that – and what it is about comics that attracts so many autistic people in the first place – have never been fully explored.

The online survey will begin to answer these questions by collecting information from autistic comics fans and creators. Professor Jenny Gibson, an expert in neurodiversity and autism and one of the project’s academic leads, described it as “kick-starting a wider conversation about comics and autism”.

“Comics seem to have massive appeal for a surprising number of autistic people, and many of them are not just fans but enormously talented cartoonists, artists and illustrators,” Gibson said.

“This is something the comics community is increasingly aware of, and there is a lot of enthusiasm for becoming better allies for autistic people. What we lack is information about how we can best do that, partly because we don’t know enough about the perspectives and experiences of autistic comics enthusiasts.”

The project is called “The Collaboration for Comics and Autism”. As well as the CCIC, Gibson and co-lead Dr Joe Sutliff Sanders will be working with the Lakes International Comic Art Festival, Dekko Comics (a specialist publisher supporting neurodivergent learners), the Association of Illustrators, the Quentin Blake Centre for Illustration and autistic cartoonists Bex Ollerton and Eliza Fricker.

Beyond this, they want to involve as many autistic artists and fans as possible by gathering their experiences of engaging with comics culture and of the opportunities and barriers they have encountered.

Various explanations have been proposed for why comics seem to have such appeal for autistic people. Dekko Comics argues on its website that many autistic young people, who may often find verbal communication challenging, respond positively to the clear and accessible sensory material in comics, which may be an important bridge between their inner and outer worlds. Research by Dr Neil Cohn suggests that over 90% of children with autism spectrum disorder and language disorders enjoy comics, compared with about 60% of neurotypical children.

Comics and art also provide many autistic people with a valuable outlet for self-expression. The Cambridge project, for example, originated from a workshop at the People’s History Museum in Manchester for autistic comics artists, which Gibson and Sanders co-led with the editor of Sensory: Life on the Spectrum, an anthology by dozens of autistic creators.

Sanders, a leading comics scholar, also highlights the richly detailed imaginative world of comics in which fans immerse themselves, often becoming aficionados in the process. This may mean comics are particularly well suited to helping autistic people satisfy psychological needs that we all share, such as the need for a sense of belonging, competence, and having control over our own lives.

“Comics have the power to spark a particular kind of obsession and passion among fans,” Sanders said. “They enable a sort of flow state; that pure joy that comes from losing yourself in something that you find interesting and engaging. They are almost ready-made for accumulating knowledge and sharing it with like-minded people who will really value what you have to say.”

“The problem is that, like so many other parts of society, fan conventions and communities – and the comics industry as a whole – can sometimes inadvertently brush aside neurodivergent people. We need to understand what we can do differently in order to make this world as inclusive and accessible as possible.”

The results of the online survey will provide the basis for a series of workshops in Cambridge later this year, during which artists, fans and people involved in the industry will begin to develop a best-practice guide for autistic inclusion.

Gibson and Sanders plan to launch it at the Lakes International Festival in September. The guide will also be distributed to a wider network including fan groups, publishers, galleries and professional bodies. It will be released as a comic book, and its impact will be tested through a follow-up survey so that it can be refined as necessary in future editions.

“Too often the question of how to support autistic people is addressed from a deficit perspective, as if the problem is that they lack neurotypical skills,” Gibson said. “This project will flip that perspective. By learning more about how autistic fans connect with comics, we will begin to understand what we can do differently to make the most of their knowledge, talents and enthusiasm.”

The initial survey for The Collaboration for Comics and Autism can be accessed here.

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Cambridge researchers are to lead a £10 million project that could result in doctors being able to predict your individual chances of getting cancer and offer personalised detection and prevention.

The UK’s strengths in population-scale data resources, combined with advanced analytical tools like AI, offer tremendous opportunities to link disparate datasets and uncover clues that could lead to earlier detection, diagnosis, and prevention of more cancersAntonis Antoniou

The Cancer Data-Driven Detection programme will be led by Antonis Antoniou, Professor of Cancer Risk Prediction at the University of Cambridge. It is funded by Cancer Research UK, the National Institute for Health and Care Research, and the Engineering and Physical Sciences Research Council.

The programme aims to access and link data from different sources – including health records, genomics, family history, demographics, and behavioural data – to develop statistical models that help scientists accurately predict who is most likely to get cancer. Alongside this, the programme will develop powerful new tools that use AI to analyse the data and calculate an individual’s risk of cancer throughout their lifetime.

Professor Antoniou said: “Finding people at the highest risk of developing cancer, including those with vague symptoms, is a major challenge. The UK’s strengths in population-scale data resources, combined with advanced analytical tools like AI, offer tremendous opportunities to link disparate datasets and uncover clues that could lead to earlier detection, diagnosis, and prevention of more cancers.”

Over the next five years, the funding will build the infrastructure required to access and link these datasets, train new data scientists, create the algorithms behind the risk models and evaluate the algorithms and AI tools to ensure that they are giving accurate and clinically useful information about cancer risk. The scientific programme will be guided by partnerships with cancer patients, the public, clinical experts and industry, while addressing ethical and legal considerations to ensure that the models and tools work well in practice.

Professor Antoniou added: “Ultimately, [the Cancer Data Driven Detection programme] could inform public health policy and empower individuals and their healthcare providers to make shared decisions. By understanding individual cancer risks, people can take proactive steps to stop cancer before it gets worse or even begins in the first place.”

The models generated from this research could be used to help people at higher risk of cancer in different ways. For example, the NHS could offer more frequent cancer screening sessions or screening at a younger age to those at higher risk, whilst those at lower risk could be spared unnecessary tests. People identified as higher risk could also be sent for cancer testing faster when they go to their GP with possible cancer signs or symptoms. Individuals at higher risk could also access different ways to prevent cancer.

Earlier diagnosis of cancer saves lives, yet according to analysis of NHS figures by Cancer Research UK, only 54% of cancers in England are diagnosed at stages one and two, where treatment is more likely to be successful. NHS England has set a target to diagnose 75% of cancers at stages one and two by 2028, and this will only be achieved with research and embracing new technologies to catch cancer earlier.  

Last week, the Prime Minister announced backing for the power of big data and AI, which has the potential to help even more patients, including those with cancer.

Science Minister Lord Vallance said: “There are huge opportunities in AI to improve UK healthcare, from scans detecting illnesses earlier to bringing NHS waiting lists down by planning appointments more efficiently, and these will continue to develop.

“This investment in harnessing the potential of data to spot those at risk of cancer represents the sort of innovation the Government’s new AI Opportunities Action Plan sets out to realise, so this technology improves lives, while transforming public services and boosting growth.”

Minister for Public Health and Prevention, Andrew Gwynne said: “Using the latest technology could revolutionise how the NHS diagnoses and treats patients. As part of this government’s Plan for Change, we will transform our health service from analogue to digital, and innovative projects like this show exactly how we will achieve it.” 

The Cancer Data Driven Detection programme is jointly supported by Cancer Research UK, the National Institute for Health & Care Research, the Engineering & Physical Sciences Research Council, Health Data Research UK, and Administrative Data Research UK.

Head of Prevention and Early Detection Research at Cancer Research UK, Dr David Crosby, said: “The single most important thing we can do to beat cancer is to find it earlier, when treatment is more likely to be successful. With half a million cancer cases per year expected in the UK by 2040, we need a major shift towards more accurate diagnosis and detection of early cancer.”

Find out how Cambridge is Changing the Story of Cancer

Adapted from a press release from Cancer Research UK

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A new study has found that the composition of your gut microbiome helps predict how likely you are to succumb to potentially life-threatening infection with Klebsiella pneumoniae, E.coli and other bugs – and it may be altered by changing your diet.

Our results suggest that what we eat is potentially very important in controlling the likelihood of infection with a range of bacteria.Alexandre Almeida

The group of bacteria called Enterobacteriaceae, including Klebsiella pneumoniae, Shigella, E.coli and others, is present at low levels as part of a healthy human gut microbiome. But at high levels – caused for example by increased inflammation in the body, or by eating contaminated food – these bugs can cause illness and disease. In extreme cases, too much Enterobacteriaceae in the gut can be life-threatening.

Researchers have used computational approaches including AI to analyse the gut microbiome composition of over 12,000 people across 45 countries from their stool samples. They found that a person’s microbiome ‘signature’ can predict whether a person’s gut is likely to be colonised by Enterobacteriaceae. The results are consistent across different states of health and geographic locations.

The researchers identified 135 gut microbe species that are commonly found in the absence of Enterobacteriaceae, likely protecting against infection.

Notable amongst the protective gut species are a group of bacteria called Faecalibacterium, which produce beneficial compounds called short-chain fatty acids by breaking down fibre in the foods we eat. This seems to protect against infection by a range of disease-causing Enterobacteriaceae bugs.

The researchers suggest that eating more fibre in our diet will support the growth of good bacteria – and crowd out the bad ones to significantly reduce the risk of illness.

In contrast, taking probiotics – which don’t directly change the environment in the gut – is less likely to affect the likelihood of Enterobacteriaceae infection.

The results are published today in the journal Nature Microbiology. 

“Our results suggest that what we eat is potentially very important in controlling the likelihood of infection with a range of bacteria, including E.coli and Klebsiella pneumoniae, because this changes our gut environment to make it more hostile to invaders,” said Dr Alexandre Almeida, a researcher at the University of Cambridge’s Department of Veterinary Medicine and senior author of the paper.

He added: “By eating fibre in foods like vegetables, beans and whole grains, we can provide the raw material for our gut bacteria to produce short chain fatty acids – compounds that can protect us from these pathogenic bugs.”

Klebsiella pneumonia can cause pneumonia, meningitis and other infections. The alarming global rise in antibiotic resistance to this bacterial pathogen has led scientists to look for new ways of keeping it, and other similar infectious bacteria, under control. 

“With higher rates of antibiotic resistance there are fewer treatment options available to us. The best approach now is to prevent infections occurring in the first place, and we can do this by reducing the opportunities for these disease-causing bacteria to thrive in our gut,” said Almeida.

A new understanding of gut microbe interactions

Earlier research to understand interactions between the different bacteria in our gut has used mouse models. But some of these new results are at odds with previous findings. 

The new study revealed that 172 species of gut microbe can coexist with disease-causing Enterobacteriaceae bugs. Many of these species are functionally similar to the bugs: they need the same nutrients to survive. Previously it was thought that competition for resources would stop the disease-causing bacteria from getting established in the gut.

This has important implications for treatment: taking probiotics that compete for the same nutrients with the bad bacteria to try and starve them out isn’t going to work. The researchers say that it will be more beneficial to change the environment in the gut, for instance through diet, to reduce the risk of infection with Enterobacteriaceae.

“This study highlights the importance of studying pathogens not as isolated entities, but in the context of their surrounding gut microbiome,” said Dr Qi Yin, a visiting researcher at the University of Cambridge’s Department of Veterinary Medicine and first author of the report.

The research was funded by the Medical Research Council.

Reference: Yin, Q. et al: ‘Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations.’ Jan 2025, Nature Microbiology. DOI: 10.1038/s41564-024-01912-6.

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